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Chlorthalidone
drug data and news
Chlorthalidone drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Chlorthalidone | ||
| Brand Names/Synonyms | Chlorothalidone; Chlorphthalidolone; Chlorphthalidone; Chlortalidone; Chlorthalidon; Chlorthalidone; Clodronic Acid; Higroton; Hydro-Long; Hygroton; Igroton; Isoren; Natriuran; Oradil; Phthalamodine; Phthalamudine; Renon; Saluretin; Tenoretic; Thalitone; Zambesil | ||
| Indication | For management of hypertension either as the sole therapeutic agent or to enhance the effect of other antihypertensive drugs in the more severe forms of hypertension. | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Chlorthalidone, a monosulfonamyl diuretic, differs form other thiazide diuretics in that a double ring system is incorporated into its structure. Chlorthalidone is used alone or with atenolol in the management of hypertension and edema. | ||
| Mechanism Of Action | Chlorthalidone inhibits sodium ion transport across the renal tubular epithelium in the cortical diluting segment of the ascending limb of the loop of Henle. By increasing the delivery of sodium to the distal renal tubule, Chlorthalidone indirectly increases potassium excretion via the sodium-potassium exchange mechanism. | ||
| Chlorthalidone News (When available) |
Cardiovascular Outcomes in High-Risk Hypertensive Patients ... Feb 8, 2006 WHERE DO DIET PILLS FIT INTO WEIGHT-CONTROL PROGRAMS? Jan 18, 2006 Pills can help win weight-loss fight Jan 10, 2006 Journal your food intake Jan 19, 2006 UF physicians offer free blood pressure screenings during Martin ... Jan 13, 2006 'Water pill' recommended first for blood pressure Sep 11, 2005 Many meds don't mix with the sun Sep 21, 2005 Strategies to Prevent Type 2 Diabetes Aug 12, 2005 Hypertension Therapy Prevents Heart Failure Among Elderly Jul 17, 2005 Diuretics prevent hypertension complications in black patients Jul 18, 2005 Diabetics With High Blood Pressure Benefit From 'Water Pills' Jun 27, 2005 Diuretics Effective for People with Diabetes and High Blood ... Jun 27, 2005 Water pills best for diabetics with high blood pressure:- Jun 28, 2005 Diuretics effective for people with diabetes and high blood ... Jun 27, 2005 Pfizer Will Present ALLHAT During Antihypertensive Class Labeling ... Jun 14, 2005 Millions of Patients Are Not at JNC 7 BP Goal Jun 26, 2005 Diuretics effective for people with diabetes and high blood ... 13 Sep 2002 Pfizer Will Present ALLHAT During Antihypertensive Class Labeling ... Jun 14, 2005 NHF adds seven new drugs to individual benefits Apr 27, 2005 FDA Safety Labeling Changes: Lotronex, Cancidas, Tenoretic May 4, 2005 NHF adds seven new drugs to individual benefits 28 Apr 2005 Diuretics Are Color Blind Apr 5, 2005 Diuretics May Be Appropriate First-Line Antihypertensive Therapy ... Apr 5, 2005 Hypertension, diuretics work better than newer therapies Apr 8, 2005 'Water pill' best start for curbing blood pressure Apr 6, 2005 Hypertension Called Color Blind: Start All with Diuretics Apr 5, 2005 Diuretics are better for treating blood pressure problems than ... Apr 15, 2005 Diuretics Best Initial Therapy in Treating High Blood Pressure Apr 5, 2005 This Week in JAMA Apr 5, 2005 A 44-Year-Old Woman With Kidney Stones Mar 1, 2005 Spreading the word Mar 2, 2005 BCBSNC Launches New Prescription Drug Savings Initiative Feb 17, 2005 Management of Hypertension in Older Persons Feb 21, 2005 | ||
| Dosage Forms | tablets | ||
| Drug_Category | Diuretics; Antihypertensive Agents; ATC:C03BA | ||
| Absorption | Absorbed relatively rapidly after oral administration | ||
| Interactions |
Interactions for Chlorthalidone: Chlorthalidone may add to or potentiate the action of other antihypertensive drugs. Potentiation occurs with ganglionic peripheral adrenergic blocking drugs. Medication such as digitalis may also influence serum electrolytes. Warning signs, irrespective of cause, are: dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting. Insulin requirements in diabetic patients may be increased, decreased, or unchanged. Higher dosage of oral hypoglycemic agents may be required. Latent diabetes mellitus may become manifest during chlorthalidone administration. Chlorthalidone and related drugs may increase the responsiveness to tubocurarine. Chlorthalidone and related drugs may decrease arterial responsiveness to norepinephrine. This diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use. | ||
| Toxicity | nausea, weakness, dizziness and disturbances of electrolyte balance. | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 2-chloro-5-(1-hydroxy-3-oxo-1,2-dihydroisoindol-1-yl)-benzenesulfonamide | ||
| Chemical Formula | C14H11ClN2O4S | ||
| Molecular Weight | 338.767 g/mol | ||
| Smiles String | C1=CC=C2C(=C1)C(=O)NC2(C3=CC(=C(C=C3)Cl)S(=O)(=O)N)O | ||
| Melting Point | 218-264°C | ||
| Water Solubility | 12mg/100ml | ||
| State | Solid | ||
| LogP/Hphobicity | 1.718 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | liver | ||
| Half Life | 40 hours | ||
| Protein Binding [%] | High (75% [58% to albumin]) | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Chlorthalidone.html http://www.rxlist.com/cgi/generic3/chlorthalidone.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00127 | ||
| CAS Registry Number | 77-36-1 | ||
| KEGG Compound ID | C06908 | ||
| PubChem ID | SID:149435 | ||
| PharmGKB ID | Not Available | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 360279 |
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