Chlorpropamide drug data and news

Chlorpropamide drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name Chlorpropamide
Brand Names/Synonyms Adiaben; Apo-Chlorpropamide; Asucrol; Catanil; Chlorodiabina; Chloronase; Chloropropamide; Chlorpropamid; Chlorpropamide; Chlorpropamide Bp/ Usp; Clorpropamide; Diabaril; Diabechlor; Diabenal; Diabenese; Diabeneza; Diabet-Pages; Diabetoral; Diabinese; Diamel Ex; Dynalase; Glisema; Glucamide; Hexathane; Insulase; Meldian; Melitase; Mellinese; Millinese; Novo-Propamide; Oradian; P 607; P-607; Stabinol; U-9818
Indication For managing hyperglycemia in Non-insulin-dependent diabetes mellitus (NIDDM).
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Description Not Available
Pharmacology Chlorpropamide, a second-generation sulfonylurea antidiabetic agent, is used with diet to lower blood glucose levels in patients with diabetes mellitus type II. Chlorpropamide is twice as potent as the related second-generation agent glipizide.
Mechanism Of Action Sulfonylureas such as Chlorpropamide likely bind to ATP-sensitive potassium-channel receptors on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. Depolarization stimulates calcium ion influx through voltage-sensitive calcium channels, raising intracellular concentrations of calcium ions, which induces the secretion, or exocytosis, of insulin.
Chlorpropamide News
(When available)

NPPA Fixes/Revises Prices Of Bulk Drugs And Formulations  Feb 1, 2006
...the submissions of manufacturers and available information with NPPA has decided that the existing notified price of bulk drug Chlorpropamide be continued. ... - Indlaw.com,

NPPA Fixes/Revises Prices Of Bulk Drugs And Formulations  Feb 1, 2006
...the submissions of manufacturers and available information with NPPA has decided that the existing notified price of bulk drug Chlorpropamide be continued. ... - Indlaw.com,

Risks of sulfonylurea drugs in the treatment of diabetes mellitus  Jan 16, 2006
Patients who were prescribed a sulfonylurea drug (chlorpropamide, tolbutamide or glyburide) experienced higher mortality rates than those who received metformin ... - EurekAlert (press release),

Reversible Hyponatremia and Venlafaxine  Sep 23, 2005
...age, malignancy, pulmonary disease, and CNS lesions) and may be medication-induced (eg, thiazide diuretics, vincristine, cyclophosphamide, and chlorpropamide). ... - Psychosomatics (subscription)

Reversible Hyponatremia and Venlafaxine  Sep 6, 2005
...age, malignancy, pulmonary disease, and CNS lesions) and may be medication-induced (eg, thiazide diuretics, vincristine, cyclophosphamide, and chlorpropamide). ... - Psychosomatics (subscription) <**results**>

Top 10 Things to Know About Diabetes Pills  Jul 4, 2005
Second World War. Chlorpropamide (brand name Diabinese) is the only first-generation sulfonylurea still in use today. This pill ... - About Diabetes

Reminder: Keep medicines away from children  Apr 5, 2005
...derivatives (chloroquine, hydroxychloroquine), tricyclic antidepressants(amitriptyline, desipramine) and certain oral hypoglycemics (chlorpropamide, glipizide ... - Staten Island Advance,

Are You In the Danger Zone?  Mar 11, 2005
...levels, pancreatitis, or heart or kidney diseases; pregnant women; type 1s who are prone to hypoglycemia; type 2s who have chlorpropamide- alcohol flush; or ... - Diabetes Interview,

Inappropriate medication prescribed to elderly  Mar 8, 2005
The medications cited as ''Always avoid'' are: barbiturates, belladonna alkaloids, chlorpropamide, dicyclomine, flurazepam, hyoscyamine, meperidine, meprobamate ... - Helena Independent Record,

Dosage Forms TABLET
Drug_Category Hypoglycemic Agents; Sulfonylureas; ATC:A10BB02
Absorption Not Available
Interactions -->Interactions for Chlorpropamide:

The hypoglycemic action of sulfonylurea may be potentiated by certain drugs including nonsteroidal anti-inflammatory agents and other drugs that are highly protein bound, salicylates, sulfonamides, chloramphenicol, probenecid, coumarins, monoamine oxidase inhibitors, and beta adrenergic blocking agents. When such drugs are administered to a patient receiving DIABINESE, the patient should be observed closely for hypoglycemia. When such drugs are withdrawn from a patient receiving DIABINESE, the patient should be observed closely for loss of control.

Certain drugs tend to produce hyperglycemia and may lead to loss of control. These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blocking drugs, and isoniazid. When such drugs are administered to a patient receiving DIABINESE, the patient should be closely observed for loss of control. When such drugs are withdrawn from a patient receiving DIABINESE, the patient should be observed closely for hypoglycemia.

Since animal studies suggest that the action of barbiturates may be prolonged by therapy with chlorpropamide, barbiturates should be employed with caution. In some patients, a disulfiram-like reaction may be produced by the ingestion of alcohol.

A potential interaction between oral miconazole and oral hypoglycemic agents leading to severe hypoglycemia has been reported. Whether this interaction also occurs with the intravenous, topical, or vaginal preparations of miconazole is not known.

Toxicity IPN-RAT LD50 580 mg/kg
Organisms Affected Humans and other mammals
Chemical IUPAC Name N-(4-chlorophenyl)sulfonylmethanamide
Chemical Formula C10H13ClN2O3S
Molecular Weight 276.741 g/mol
Smiles String CCCNC(=O)NS(=O)(=O)C1=CC=C(C=C1)Cl
Melting Point 127 - 129 °C
Water Solubility Solubility at pH 6 is 2.2 mg/ml
State Solid
LogP/Hphobicity 2.653
Isoelectric Point Not Available
Biotransformation Not Available
Half Life 36 hours
Protein Binding [%] Not Available
RxList Link RXlist
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Drug Reference http://www.drugs.com/cons/Chlorpropamide.html
http://www.rxlist.com/cgi/generic2/chlorpro.htm
Drug Type Approved Drug
Accession No APRD00029
CAS Registry Number 94-20-2
KEGG Compound ID C06907
PubChem ID SID:150222
PharmGKB ID PA448966
SwissProt ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] 156728

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