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Chlorpropamide
drug data and news
Chlorpropamide drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Chlorpropamide | ||
| Brand Names/Synonyms | Adiaben; Apo-Chlorpropamide; Asucrol; Catanil; Chlorodiabina; Chloronase; Chloropropamide; Chlorpropamid; Chlorpropamide; Chlorpropamide Bp/ Usp; Clorpropamide; Diabaril; Diabechlor; Diabenal; Diabenese; Diabeneza; Diabet-Pages; Diabetoral; Diabinese; Diamel Ex; Dynalase; Glisema; Glucamide; Hexathane; Insulase; Meldian; Melitase; Mellinese; Millinese; Novo-Propamide; Oradian; P 607; P-607; Stabinol; U-9818 | ||
| Indication | For managing hyperglycemia in Non-insulin-dependent diabetes mellitus (NIDDM). | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Chlorpropamide, a second-generation sulfonylurea antidiabetic agent, is used with diet to lower blood glucose levels in patients with diabetes mellitus type II. Chlorpropamide is twice as potent as the related second-generation agent glipizide. | ||
| Mechanism Of Action | Sulfonylureas such as Chlorpropamide likely bind to ATP-sensitive potassium-channel receptors on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. Depolarization stimulates calcium ion influx through voltage-sensitive calcium channels, raising intracellular concentrations of calcium ions, which induces the secretion, or exocytosis, of insulin. | ||
| Chlorpropamide News (When available) |
NPPA Fixes/Revises Prices Of Bulk Drugs And Formulations Feb 1, 2006 NPPA Fixes/Revises Prices Of Bulk Drugs And Formulations Feb 1, 2006 Risks of sulfonylurea drugs in the treatment of diabetes mellitus Jan 16, 2006 Reversible Hyponatremia and Venlafaxine Sep 23, 2005 Reversible Hyponatremia and Venlafaxine Sep 6, 2005 Top 10 Things to Know About Diabetes Pills Jul 4, 2005 Reminder: Keep medicines away from children Apr 5, 2005 Are You In the Danger Zone? Mar 11, 2005 Inappropriate medication prescribed to elderly Mar 8, 2005 | ||
| Dosage Forms | TABLET | ||
| Drug_Category | Hypoglycemic Agents; Sulfonylureas; ATC:A10BB02 | ||
| Absorption | Not Available | ||
| Interactions |
-->Interactions for Chlorpropamide: The hypoglycemic action of sulfonylurea may be potentiated by certain drugs including nonsteroidal anti-inflammatory agents and other drugs that are highly protein bound, salicylates, sulfonamides, chloramphenicol, probenecid, coumarins, monoamine oxidase inhibitors, and beta adrenergic blocking agents. When such drugs are administered to a patient receiving DIABINESE, the patient should be observed closely for hypoglycemia. When such drugs are withdrawn from a patient receiving DIABINESE, the patient should be observed closely for loss of control. Certain drugs tend to produce hyperglycemia and may lead to loss of control. These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blocking drugs, and isoniazid. When such drugs are administered to a patient receiving DIABINESE, the patient should be closely observed for loss of control. When such drugs are withdrawn from a patient receiving DIABINESE, the patient should be observed closely for hypoglycemia. Since animal studies suggest that the action of barbiturates may be prolonged by therapy with chlorpropamide, barbiturates should be employed with caution. In some patients, a disulfiram-like reaction may be produced by the ingestion of alcohol. A potential interaction between oral miconazole and oral hypoglycemic agents leading to severe hypoglycemia has been reported. Whether this interaction also occurs with the intravenous, topical, or vaginal preparations of miconazole is not known. | ||
| Toxicity | IPN-RAT LD50 580 mg/kg | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | N-(4-chlorophenyl)sulfonylmethanamide | ||
| Chemical Formula | C10H13ClN2O3S | ||
| Molecular Weight | 276.741 g/mol | ||
| Smiles String | CCCNC(=O)NS(=O)(=O)C1=CC=C(C=C1)Cl | ||
| Melting Point | 127 - 129 °C | ||
| Water Solubility | Solubility at pH 6 is 2.2 mg/ml | ||
| State | Solid | ||
| LogP/Hphobicity | 2.653 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Not Available | ||
| Half Life | 36 hours | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Chlorpropamide.html http://www.rxlist.com/cgi/generic2/chlorpro.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00029 | ||
| CAS Registry Number | 94-20-2 | ||
| KEGG Compound ID | C06907 | ||
| PubChem ID | SID:150222 | ||
| PharmGKB ID | PA448966 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 156728 |
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