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Chlorpromazine
drug data and news
Chlorpromazine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Chlorpromazine | ||
| Brand Names/Synonyms | Largactil; Contomin; Chlorpromados; Chlorderazin; Ampliactil; Aminazine; Aminazin; Fenactil; Fenaktyl; Chlorpromanyl-20; Chlorpromanyl-40; Chlorpromazine Hydrochloride Intensol; Largactil Liquid; Largactil Oral Drops; Novo-Chlorpromazine; Thorazine; Thorazine Spansule | ||
| Indication | For the treatment of schizophrenia, control nausea and vomiting, For relief of restlessness and apprehension before surgery, adjunct in the treatment of tetanus, control the manifestations of the manic type of manic-depressive illness. | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Chlorpromazine is a psychotropic agent indicated for the treatment of schizophrenia. It also exerts sedative and antiemetic activity. Chlorpromazine has actions at all levels of the central nervous system-primarily at subcortical levels-as well as on multiple organ systems. Chlorpromazine has strong antiadrenergic and weaker peripheral anticholinergic activity; ganglionic blocking action is relatively slight. It also possesses slight antihistaminic and antiserotonin activity. | ||
| Mechanism Of Action | Chlorpromazine acts as an antagonist (blocking agent) on different postsysnaptic receptors -on dopaminergic-receptors (subtypes D1, D2, D3 and D4 - different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenuation of extrapypramidal side-effects, but also leading to weight gain, fall in blood pressure, sedation and ejaculation difficulties), on histaminergic-receptors (H1-receptors, sedation, antiemesis, vertigo, fall in blood pressure and weight gain), alpha1/alpha2-receptors (antisympathomimetic properties, lowering of blood pressure, reflex tachycardia, vertigo, sedation, hypersalivation and incontinence as well as sexual dysfunction, but may also attenuate pseudoparkinsonism - controversial) and finally on muscarinic (cholinergic) M1/M2-receptors (causing anticholinergic symptoms like dry mouth, blurred vision, obstipation, difficulty/inability to urinate, sinus tachycardia, ECG-changes and loss of memory, but the anticholinergic action may attenuate extrapyramidal side-effects). Additionally, Chlorpromazine is a weak presynaptic inhibitor of Dopamine reuptake, which may lead to (mild) antidepressive and antiparkinsonian effects. This action could also account for psychomotor agitation and amplification of psychosis (very rarely noted in clinical use). | ||
| Chlorpromazine News (When available) |
DRD2 Promoter Region Variation as a Predictor of Sustained ... Mar 2, 2006 Sex Differences in Language Dysfunction in Schizophrenia Mar 2, 2006 Monoaminergic Treatment of Schizophrenia Feb 27, 2006 Lifetime suicide rates in treated schizophrenia: 1875–1924 and ... Feb 28, 2006 Dr. Lieberman and Colleagues Reply Mar 2, 2006 Sildenafil in the Treatment of Antipsychotic-Induced Erectile ... Mar 2, 2006 Biofusion launches spin-out company Genophrenix Feb 22, 2006 Health Tip: Drugs to Avoid While Breast-Feeding Feb 16, 2006 Myocarditis During Clozapine Treatment Feb 14, 2006 DEATH, TOXINS AND REPRESENTATION Feb 8, 2006 Bipolar Disorder Treatment: An Evidence-Based Reality Check Feb 14, 2006 Psychiatric drugs restored Nia's sanity and destroyed her beauty ... Jan 25, 2006 Brief Reports: Patterns of Psychotropic Medication Use by Race ... Jan 25, 2006 A Horrific Case of Hiccups, a Novel Treatment Jan 9, 2006 The phone that can steer you away from traffic hell Jan 13, 2006 Extra suicide care call Jan 24, 2006 Time to repay debt to developing nations Jan 18, 2006 Personal Accounts: My Experiences as a Psychiatric Patient in the ... Dec 10, 2005 Older Antipsychotic Drugs Called Risky Compared With Atypical ... Nov 30, 2005 The Discriminated Nov 8, 2005 Kissy Mental Hospital in Sierra Leone teaches International ... Nov 9, 2005 The Lobotomist: A Maverick Medical Genius and His Tragic Quest to ... Oct 9, 2005 Treatment for mental illness falls short Oct 2, 2005 An Update of Fast-Off Dopamine D 2 Atypical Antipsychotics Sep 30, 2005 Through the Times With Max Fink, MD Oct 3, 2005 Schizophrenia treatment lags Sep 20, 2005 Limitations of rapid tranquillisation trial Aug 1, 2005 Opiates better than sedatives for treating newborns in withdrawal Jul 29, 2005 Parents charged with murdering son Jul 7, 2005 Dementia drugs don't increase stroke risk Aug 2, 2005 Schizophrenia drug can curb loss of brain cells Aug 1, 2005 Rational pharmacotherapy in early psychosis * Jul 29, 2005 Reduced Left Angular Gyrus Volume in First-Episode Schizophrenia Jul 29, 2005 Acute Akathisia Associated With Quetiapine Use Jul 6, 2005 Schneiderian First-Rank Symptoms and Right Parietal ... Jul 29, 2005 A brief history of psychiatry Jul 25, 2005 Textbook of Geriatric Psychiatry, Third Edition Jul 14, 2005 When home remedies for hiccups fail, medicines can usually end ... Jul 20, 2005 Alleviating the Itch-Scratch Cycle in Atopic Dermatitis Jul 6, 2005 | ||
| Dosage Forms | DROPS; LIQUID; SOLUTION; SYRUP; TABLET | ||
| Drug_Category | Antipsychotics; Antiemetics; Dopamine Antagonists; Phenothiazines; ATC:N05AA01 | ||
| Absorption | Not Available | ||
| Interactions | Interactions for Chlorpromazine: The concurrent use of two or more drugs with anticholinergic activity--such as an antipsychotic drug (eg, chlorpromazine), an antiparkinsonian drug (eg, trihexyphenidyl), and/or a tricyclic antidepressant (eg, amitriptyline)--commonly results in excessive anticholinergic effects, including dry mouth and associated dental complications, blurred vision, and, in patients exposed to high temperature and humidity, hyperpyrexia. Interactions may also occur with the following: anti-depressants/anti-anxiety drugs, drugs used to treat an overactive thyroid, beta-blockers (e.g., propranolol), sparfloxacin, grepafloxacin, guanethidine, guanadrel, metrizamide, cabergoline, lithium, narcotic pain medication (e.g., codeine), drugs used to aid sleep, drowsiness-causing antihistamines (e.g., diphenhydramine), any other drugs that may make you drowsy. | ||
| Toxicity | Agitation, coma, convulsions, difficulty breathing, difficulty swallowing, dry mouth, extreme sleepiness, fever, intestinal blockage, irregular heart rate, low blood pressure, restlessness | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-propan-1-amine | ||
| Chemical Formula | C17H19ClN2S | ||
| Molecular Weight | 318.865 g/mol | ||
| Smiles String | CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl | ||
| Melting Point | < 25 °C | ||
| Water Solubility | 2.55 mg/L | ||
| State | Liquid | ||
| LogP/Hphobicity | 5.512 | ||
| Isoelectric Point | 9.3 | ||
| Biotransformation | Not Available | ||
| Half Life | Not Available | ||
| Protein Binding [%] | 40% | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/chl1441.shtml http://www.drugs.com/cons/Chlorpromazine.html http://www.rxlist.com/cgi/generic3/chlorpromazine.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00482 | ||
| CAS Registry Number | 50-53-3 | ||
| KEGG Compound ID | C06906 | ||
| PubChem ID | SID:148556 | ||
| PharmGKB ID | PA448964 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 21342 |
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