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Chloroprocaine
drug data and news
Chloroprocaine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Chloroprocaine | ||
| Brand Names/Synonyms | Astracaine 4%; Astracaine 4% Forte; CHLOROPROCAINE; Carbocaine; Carbocaine with Neo-Cobefrin; Chirocaine; Chlor-Procaine; Chloroprocain; Chloroprocaine; Chloroprocaine Hcl; Chloroprocainum [Inn-Latin]; Chlorprocaine; Chlorprocainum; Citanest Forte; Citanest Plain; Cloroprocaina [Inn-Spanish]; Dalcaine; Dilocaine; Duranest; Duranest-Mpf; HSDB 3301; Halestyn; Isocaine; Isocaine 2%; Isocaine 3%; L-Caine; Lidoject-1; Lidoject-2; Marcaine; Marcaine Spinal; Nesacaine; Nesacaine-Ce; Nesacaine-Mpf; Novocain; Octocaine; Octocaine-100; Octocaine-50; Piocaine; Polocaine; Polocaine-Mpf; Pontocaine; Sensorcaine; Sensorcaine Forte; Sensorcaine-Mpf; Sensorcaine-Mpf Spinal; Septocaine; Ultracaine D-S; Ultracaine D-S Forte; Xylocaine; Xylocaine 5% Spinal; Xylocaine Test Dose; Xylocaine-Mpf; Xylocaine-Mpf with Glucose | ||
| Indication | For the production of local anesthesia by infiltration and peripheral nerve block. They are not to be used for lumbar or caudal epidural anesthesia. | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Chloroprocaine is an anesthetic agent indicated for production of local or regional anesthesia, particularly for oral surgery. Chloroprocaine (like cocaine) has the advantage of constricting blood vessels which reduces bleeding, unlike other local anesthetics like lidocaine. Chloroprocaine is an ester anesthetic. | ||
| Mechanism Of Action | Chloroprocaine acts mainly by inhibiting sodium influx through voltage gated sodium channels in the neuronal cell membrane of peripheral nerves. When the influx of sodium is interrupted, an action potential cannot arise and signal conduction is thus inhibited. The receptor site is thought to be located at the cytoplasmic (inner) portion of the sodium channel. Chloroprocaine has also been shown to bind or antagonize the function of N-methyl-D-aspartate (NMDA) receptors as well as nicotinic acetylcholine receptors and the serotonin receptor-ion channel complex. | ||
| Chloroprocaine News (When available) |
Abraxis BioScience Announces Co-Promotion Agreement with ... Apr 26, 2006 Abraxis BioScience Announces Co-Promotion Agreement with ... Apr 27, 2006 | ||
| Dosage Forms | LIQUID | ||
| Drug_Category | Anesthetics; Local Anesthetics; ATC:N01BA04 | ||
| Absorption | Not Available | ||
| Interactions |
Interactions for Chloroprocaine: The administration of local anesthetic solutions containing epinephrine or norepinephrine to patients receiving monoamine oxidase inhibitors, tricyclic antidepressants or phenothiazines may produce severe, prolonged hypotension or hypertension. Concurrent use of these agents should generally be avoided. In situations when concurrent therapy is necessary, careful patient monitoring is essential. Concurrent administration of vasopressor drugs (for the treatment of hypotension related to obstetric blocks) and ergot-type oxytocic drugs may cause severe, persistent hypertension or cerebrovascular accidents. The para-aminobenzoic acid metabolite of chloroprocaine inhibits the action of sulfonamides. Therefore, chloroprocaine should not be used in any condition in which a sulfonamide drug is being employed. | ||
| Toxicity | Not Available | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 2-diethylaminoethyl4-amino-2-chloro-benzoate | ||
| Chemical Formula | C13H19ClN2O2 | ||
| Molecular Weight | 270.755 g/mol | ||
| Smiles String | CCN(CC)CCOC(=O)C1=C(C=C(C=C1)N)Cl | ||
| Melting Point | Not Available | ||
| Water Solubility | 665 mg/L | ||
| State | Solid | ||
| LogP/Hphobicity | 2.464 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Not Available | ||
| Half Life | 21 +/- 2 seconds | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Chloroprocaine.html http://www.rxlist.com/cgi/generic3/chloroprocaine.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00404 | ||
| CAS Registry Number | 133-16-4 | ||
| KEGG Compound ID | C07877 | ||
| PubChem ID | SID:10079 | ||
| PharmGKB ID | PA448946 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 613304 |
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