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Chlorhexidine
drug data and news
Chlorhexidine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Chlorhexidine | ||
| Brand Names/Synonyms | Bioscrub; Brian Care; C6143; CHEMBANK1360; CHLORHEXIDINE BAS; Chlorhexidin; Chlorhexidin [Czech]; Chlorhexidine; Chlorhexidine Base; Chlorhexidine Gluconate; Chlorhexidine, Free Base; Chlorhexidinum [Inn-Latin]; Cida-Stat; Cloresidina [Dcit]; Clorhexidina [Inn-Spanish]; Decanoylacetaldehyde Sodium Sulfide; Dyna-Hex; E-Z Scrub; Exidine; Fimeil; HSDB 7196; Hexadol; Hibiclens; Hibidil; Hibiscrub; Hibisol; Hibispray; Hibistat; Hibitane; Microderm; Nolvasan; Oro-Clense; Peridex; Periochip; Periogard; Pharmaseal Scrub Care; Prevacare R; Rotersept; Savloclens; Savlon Babycare; Sodium Houttuyfonamide; Soretol; Steri-Stat; Sterido; Sterilon; Superspray; Tubulicid | ||
| Indication | For reduction of pocket depth in patients with adult periodontitis, used as an adjunct to scaling and root planing procedures; For prevention of dental caries, oropharyngeal decontamination in critically ill patients; hand hygiene in health-care personnel; general skin cleanser; and catheter site preparation and care. | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Chlorhexidine, a topical antimicrobial agent, is used orally to treat mucositis, mouth infections, denture stomatitis, ulcerative stomatitis, acute necrotizing ulcerative gingivitis (ANUG), gingivitis, periodontitis and topically as an antiseptic and disinfectant. | ||
| Mechanism Of Action | Chlorhexidine's antimicrobial effects are associated with the attractions between chlorhexidine (cation) and negatively charged bacterial cells. After chlorhexidine is absorpted onto the organism's cell wall, it disrupts the integrity of the cell membrane and causes the leakage of intracellular components of the organisms. | ||
| Chlorhexidine News (When available) |
Think twice before keeping a monkey as a domestic pet 06 Mar 2006 Mercy to participate in 100,000 Lives Campaign Mar 5, 2006 Good Guys Gargle Feb 22, 2006 Disinfecting Barns & Stalls Feb 27, 2006 National Initiatives Aim to Control These Killers Mar 1, 2006 Infection Prevention Made Easier With Enhanced ChloraPrep(R) Frepp ... Feb 15, 2006 Hibiclens(R) Survey Shows Initial Treatment for MRSA Varies Widely ... Feb 24, 2006 Foaling Checklist Feb 25, 2006 Treatment of External Fixation Pins About the Wrist: A Prospective ... Feb 14, 2006 Strangles: Horses at Risk Feb 16, 2006 Weekly Calendar Feb 13, 2006 Best Practices for 2006 Feb 1, 2006 Chlorascrub(TM) is Challenged by Competitor Feb 10, 2006 Skin Problems in Horses Feb 1, 2006 Attention Business, Health And Retailing Editors: Jan 19, 2006 Best Practices for 2006 Feb 1, 2006 Arrow International, Inc. Introduces Maximal Barrier Precautions ... Jan 11, 2006 Arrow International, Inc. Introduces Maximal Barrier Precautions ... Jan 11, 2006 Tehnician charged in fatal injected with cleaning solution Jan 31, 2006 Skin Problems in Horses Feb 1, 2006 (PRN) - Biffle Leads Wal-Mart FLW Tour Opener on Lake Okeechobee . ... Jan 19, 2006 Summer Haircoat Tips Jan 11, 2006 Reduction in Central Line–Associated Bloodstream Infections ... Jan 20, 2006 Hand sanitizer may help fight bird flu Jan 24, 2006 Zila Signs Agreement to Expand Distribution of Peridex(R) into ... Jan 24, 2006 Clinical trials examine a low-cost rinse to prevent tooth loss Nov 30, 2005 MP set to fight for cleaner hospitals Dec 8, 2005 Mom‘s gum disease raises risk of preterm birth Dec 4, 2005 Regent Medical Urges Distinction Between Consumer and Medical ... Dec 5, 2005 Linkwell Corporation To Help Fill Disinfectant Demand In China Nov 10, 2005 Dog owners should be aware of ear problems Nov 24, 2005 Linkwell Corporation Launches a Series of New Hand Disinfectants ... Nov 9, 2005 Effect of a Second-Generation Venous Catheter Impregnated with ... Oct 18, 2005 Lots of Elbow Grease for Disinfection Project Oct 28, 2005 Medi-Flex enters surgical arena Oct 16, 2005 Major Advancement in Surgical Skin Preparation Now Available Oct 18, 2005 Major Advancement In Surgical Skin Preparation Now Available Oct 17, 2005 Antibiotic-Coated Central Venous Catheters Reduce Bacterial ... Oct 28, 2005 Major Advancement In Surgical Skin Preparation Now Available Oct 17, 2005 'Superbug' strikes 8-year-old Oct 25, 2005 Study Shows Superiority of Venetec's StatLock for Securing ... Oct 24, 2005 RA DRUG FOR PSORIASIS Oct 18, 2005 Basic steps could save 100,000 patients Oct 5, 2005 Catheter-Related Bloodstream Infection Rates in a Pediatric ... Oct 11, 2005 Sorted: DIY cosmetic dentistry Oct 14, 2005 Catheter-Related Bloodstream Infection Rates in a Pediatric ... 11 Oct 2005 Basic steps could save 100,000 patients Oct 5, 2005 The Natural Dentist Introduces New Flavors Peppermint Twist And ... Sep 20, 2005 Cat's ringworm will take some aggressive treatment to eradicate Sep 10, 2005 | ||
| Dosage Forms | Oral rince; Pellet, extended- release; PerioChip (in a biodegradable matrix of hydrolyzed gelatin [cross-linked with glutaraldehyde]) (glycerin) (purified water); CREAM; DRESSING; GEL; LOTION; OINTMEN; SPONGE | ||
| Drug_Category | Anti-bacterial Agents; Anti-Infectives; ATC:A01AB03; ATC:B05CA02; ATC:D08AC02; ATC:D09AA12; ATC:R02AA05; ATC:S01AX09; ATC:S02AA09; ATC:S03AA04 | ||
| Absorption | absorption of chlorhexidine from the gastrointestinal tract is very poor | ||
| Interactions |
Interactions for Chlorhexidine: No information provided. | ||
| Toxicity | LD50= 2g/kg (human, oral); LD50= 3 g/kg (rat, oral); LD50= 2.5 g/kg (mice, oral); LD50= 21 mg/kg (male rat, IV); LD50= 23 mg/kg (female rat, IV); LD50= 25 mg/kg (male mice, IV); LD50= 24 mg/kg (female mice, IV); LD50= 1g/kg (rat, subcutaneous); LD50= 637 mg/kg (male mice, subcutaneous); LD50= 632 mg/kg (female mice, subcutaneous) | ||
| Organisms Affected | Enteric bacteria and other eubacteria | ||
| Chemical IUPAC Name | 1-[amino-[6-[amino-[amino-(4-chlorophenyl)amino-methylidene]amino-methylidene]aminohexylimino]methyl]imino-N-(4-chlorophenyl)-methanediamine | ||
| Chemical Formula | C22H30Cl2N10 | ||
| Molecular Weight | 505.446 g/mol | ||
| Smiles String | C1=CC(=CC=C1NC(=NC(=NCCCCCCN=C(N)N=C(N)NC2=CC=C(C=C2)Cl)N)N)Cl | ||
| Melting Point | 134 °C | ||
| Water Solubility | 0.08%(w/v) | ||
| State | Solid | ||
| LogP/Hphobicity | 4.066 | ||
| Isoelectric Point | 10.8 | ||
| Biotransformation | Not Available | ||
| Half Life | Not Available | ||
| Protein Binding [%] | 87% | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Chlorhexidine.html http://www.rxlist.com/cgi/generic2/chlorhexidine.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00545 | ||
| CAS Registry Number | 55-56-1 | ||
| KEGG Compound ID | C06902 | ||
| PubChem ID | SID:338074 | ||
| PharmGKB ID | PA448934 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2242329 |
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