Chlorhexidine drug data and news

Chlorhexidine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name Chlorhexidine
Brand Names/Synonyms Bioscrub; Brian Care; C6143; CHEMBANK1360; CHLORHEXIDINE BAS; Chlorhexidin; Chlorhexidin [Czech]; Chlorhexidine; Chlorhexidine Base; Chlorhexidine Gluconate; Chlorhexidine, Free Base; Chlorhexidinum [Inn-Latin]; Cida-Stat; Cloresidina [Dcit]; Clorhexidina [Inn-Spanish]; Decanoylacetaldehyde Sodium Sulfide; Dyna-Hex; E-Z Scrub; Exidine; Fimeil; HSDB 7196; Hexadol; Hibiclens; Hibidil; Hibiscrub; Hibisol; Hibispray; Hibistat; Hibitane; Microderm; Nolvasan; Oro-Clense; Peridex; Periochip; Periogard; Pharmaseal Scrub Care; Prevacare R; Rotersept; Savloclens; Savlon Babycare; Sodium Houttuyfonamide; Soretol; Steri-Stat; Sterido; Sterilon; Superspray; Tubulicid
Indication For reduction of pocket depth in patients with adult periodontitis, used as an adjunct to scaling and root planing procedures; For prevention of dental caries, oropharyngeal decontamination in critically ill patients; hand hygiene in health-care personnel; general skin cleanser; and catheter site preparation and care.
Sponsored links
Description Not Available
Pharmacology Chlorhexidine, a topical antimicrobial agent, is used orally to treat mucositis, mouth infections, denture stomatitis, ulcerative stomatitis, acute necrotizing ulcerative gingivitis (ANUG), gingivitis, periodontitis and topically as an antiseptic and disinfectant.
Mechanism Of Action Chlorhexidine's antimicrobial effects are associated with the attractions between chlorhexidine (cation) and negatively charged bacterial cells. After chlorhexidine is absorpted onto the organism's cell wall, it disrupts the integrity of the cell membrane and causes the leakage of intracellular components of the organisms.
Chlorhexidine News
(When available)

Think twice before keeping a monkey as a domestic pet  06 Mar 2006
At least 15 minutes of scrubbing and/or irrigating with soap solution, povidone-iodine or chlorhexidine at the exposed area is recommended. ... - Jakarta Post,

Mercy to participate in 100,000 Lives Campaign  Mar 5, 2006
...central lines from developing infections by following five steps, including proper hand-washing and cleaning the patient’s skin with chlorhexidine — a type ... - Mason City Globe Gazette,

Good Guys Gargle  Feb 22, 2006
She adds that gargling with an oral antiseptic that contains Chlorhexidine, like Astring-o-sol Specialist with Chlorhexidine, is advised. ... - Manila Bulletin,

Disinfecting Barns & Stalls  Feb 27, 2006
Commercially available disinfectants fall into ten major categories: Aldehydes, iodophors, hypochlorites (bleach), alcohols, chlorhexidine, quaternary ammonium ... - TheHorse.com,

National Initiatives Aim to Control These Killers  Mar 1, 2006
The “central line bundle� promulgated by the IHI is comprised of hand hygiene, maximal barrier precautions, chlorhexidine skin antisepsis, optimal catheter ... - Infection Control Today,

Infection Prevention Made Easier With Enhanced ChloraPrep(R) Frepp ...  Feb 15, 2006
ChloraPrep is the first 2 percent chlorhexidine gluconate (CHG) and 70 percent isopropyl alcohol (IPA) patient preoperative skin preparation to meet the Food ... - Market Wire (press release)

Hibiclens(R) Survey Shows Initial Treatment for MRSA Varies Widely ...  Feb 24, 2006
Regent Medical's antimicrobial, antiseptic product, HIBICLENS(R), contains an active ingredient - chlorhexidine gluconate (CHG) - that kills germs on contact ... - International News Service,

Foaling Checklist  Feb 25, 2006
I use povidone (Betadine) surgical solution; some vets prefer a solution of chlorhexidine (Nolvasan). Consult your vet for his/her preference. ... - EquiSearch.com,

Treatment of External Fixation Pins About the Wrist: A Prospective ...  Feb 14, 2006
...care with a solution of one-half normal saline solution and one-half hydrogen peroxide; and (3) treatment with the placement of chlorhexidine-impregnated discs ... - Journal of Bone and Joint Surgery

Strangles: Horses at Risk  Feb 16, 2006
...manure. "The organism is readily killed by heat (60°C or 140°F) or disinfectants (particularly povidone iodine and chlorhexidine). ... - TheHorse.com,

Weekly Calendar  Feb 13, 2006
17, 12:15 pm “Topical Chlorhexidine and the Umbilical Cord: Preventing Infection and Improving Neonatal Survival in Rural Nepal,� an International Health ... - Johns Hopkins Gazette,

Best Practices for 2006  Feb 1, 2006
...in the 2002 Centers for Disease Control and Prevention (CDC) Guideline for Hand Hygiene in Healthcare Settings are alcohols, chlorhexidine gluconate (CHG ... - Infection Control Today,

Chlorascrub(TM) is Challenged by Competitor  Feb 10, 2006
Chlorascrub is an FDA approved 3.15% Chlorhexidine Gluconate (CHG) and 70% Isopropyl Alcohol (IPA) formulation suitable for antisepsis prior to surgery or ... - Business Wire (press release),

Skin Problems in Horses  Feb 1, 2006
...crusting. A mild bacterial skin infection can be treated topically by washing with an antiseptic like chlorhexidine (Nolvasan). ... - TheHorse.com,

Attention Business, Health And Retailing Editors:  Jan 19, 2006
...of London's Queen Mary School of Medicine, Shows Skinvisible's Patent-Pending Chlorhexidine Hand Sanitizer is More Than 99 Percent Effective at Killing The ... - Canada NewsWire (press release),

Best Practices for 2006  Feb 1, 2006
...in the 2002 Centers for Disease Control and Prevention (CDC) Guideline for Hand Hygiene in Healthcare Settings are alcohols, chlorhexidine gluconate (CHG ... - Infection Control Today,

Arrow International, Inc. Introduces Maximal Barrier Precautions ...  Jan 11, 2006
ARROWg+ard antimicrobial catheter technology features a patented combination of silver sulfadiazine and chlorhexidine impregnated into the catheter surface. ... - Business Wire (press release),

Arrow International, Inc. Introduces Maximal Barrier Precautions ...  Jan 11, 2006
ARROWg+ard antimicrobial catheter technology features a patentedcombination of silver sulfadiazine and chlorhexidine impregnated intothe catheter surface. ... - Finanzen.net,

Tehnician charged in fatal injected with cleaning solution  Jan 31, 2006
At the conclusion, instead of being injected with a saline solution or radiological dye, she was mistakenly given chlorhexidine, a toxic antiseptic used to ... - Seattle Post Intelligencer

Skin Problems in Horses  Feb 1, 2006
...crusting. A mild bacterial skin infection can be treated topically by washing with an antiseptic like chlorhexidine (Nolvasan). ... - TheHorse.com,

(PRN) - Biffle Leads Wal-Mart FLW Tour Opener on Lake Okeechobee . ...  Jan 19, 2006
...of London's Queen Mary School of Medicine, Shows Skinvisible's Patent-Pending Chlorhexidine Hand Sanitizer is More Than 99 Percent Effective at Killi ... [+. ... - Bolsamania.com,

Summer Haircoat Tips  Jan 11, 2006
Antibacterial shampoos--which contain ingredients like iodine, chlorhexidine, and benzoil peroxide--can help prevent and correct skin problems. ... - TheHorse.com,

Reduction in Central Line–Associated Bloodstream Infections ...  Jan 20, 2006
...of targeted, evidence-based catheter insertion practices (ie, use of maximum sterile barrier precautions during insertion, use of chlorhexidine for skin ... - Journal of American Medical Association (subscription),

Hand sanitizer may help fight bird flu  Jan 24, 2006
..."We are seeking to broaden our marketing and distribution efforts in order to make our Chlorhexidine Hand Sanitizer available as soon as possible to the ... - CosmeticsDesign.com,

Zila Signs Agreement to Expand Distribution of Peridex(R) into ...  Jan 24, 2006
With a pleasant herbal mint taste, Peridex continues to work even after rinsing because one third of its active ingredient -- chlorhexidine gluconate -- binds ... - Business Wire (press release),

Clinical trials examine a low-cost rinse to prevent tooth loss  Nov 30, 2005
...pilot study conducted in Seattle between 1991-95 that showed effectiveness in reducing cavities and periodontal disease by using a chlorhexidine rinse regularly ... - uwnews.org,

MP set to fight for cleaner hospitals  Dec 8, 2005
Mrs Dorries added: "When a patient went home or, unfortunately, died, the bed and the bedside cabinet would be cleaned down with chlorhexidine solution, as ... - Comet 24,

Mom‘s gum disease raises risk of preterm birth  Dec 4, 2005
...had gum disease to no periodontal therapy or to periodontal therapy consisting of plaque control, scaling, and daily rinsing with bacteria-busting chlorhexidine ... - Leading The Charge,

Regent Medical Urges Distinction Between Consumer and Medical ...  Dec 5, 2005
...soaps from the grocery store is far different from the purchase and use of scrub and prep solutions -- those containing chlorhexidine gluconate (CHG ... - PR Newswire (press release),

Linkwell Corporation To Help Fill Disinfectant Demand In China  Nov 10, 2005
...rooms. The new product named Jifro 4% Chlorhexidine gluconate ("Jifro") is a surgical hand scrub designed for surgical applications. ... - dBusinessNews Pittsburgh (press release),

Dog owners should be aware of ear problems  Nov 24, 2005
..."Many products used to clean out the ears contain ingredients such as chlorhexidine and propylene glycol that can cause irritation or ototoxicity, especially ... - Charlotte Sun-Herald,

Linkwell Corporation Launches a Series of New Hand Disinfectants ...  Nov 9, 2005
The new product named Jifro 4% Chlorhexidine gluconate ("Jifro") is a surgical hand scrub designed for surgical applications. Recently, Johnson & Johnson, Inc. ... - Market Wire (press release)

Effect of a Second-Generation Venous Catheter Impregnated with ...  Oct 18, 2005
...catheterization. Intervention: Patients received either a standard catheter or a catheter coated with chlorhexidine and silver sulfadiazine. ... - Annals of Internal Medicine

Lots of Elbow Grease for Disinfection Project  Oct 28, 2005
...many different classes of disinfectants, including phenols, iodophores (eg, povidone iodine), hypochlorites (eg, bleach), chlorhexidine, quaternary ammonium ... - TheHorse.com,

Medi-Flex enters surgical arena  Oct 16, 2005
Schreiber said. It's now dominated by iodine-based products. ChloraPrep uses a chlorhexidine-based solution. James "Jim" Mitchum ... - El Paso Times,

Major Advancement in Surgical Skin Preparation Now Available  Oct 18, 2005
ChloraPrep(R) 26 mL - the only 2% chlorhexidine gluconate and 70% isopropyl alcohol surgical prep that is FDA approved and meets CDC guidelines LEAWOOD, Kan ... - PR Newswire (press release),

Major Advancement In Surgical Skin Preparation Now Available  Oct 17, 2005
ChloraPrep(R) 26 mL - the Only 2% Chlorhexidine Gluconate and 70% Isopropyl Alcohol Surgical Prep That is FDA Approved and Meets CDC Guidelines LEAWOOD, Kan ... - PR Newswire (press release),

Antibiotic-Coated Central Venous Catheters Reduce Bacterial ...  Oct 28, 2005
Effect of a second-generation venous catheter impregnated with chlorhexidine and silver sulfadiazine on central catheter-related infections. ... - Cancer Consultants (press release),

Major Advancement In Surgical Skin Preparation Now Available  Oct 17, 2005
...is the first FDA- approved preoperative skin prep that contains the Centers for Disease Control and Prevention (CDC)-preferred amount of chlorhexidine gluconate ... - PR Newswire (press release),

'Superbug' strikes 8-year-old  Oct 25, 2005
Wash hands two or three times a day. If soap and water aren't available, use hand wipes containing triclosan or chlorhexidine. Avoid sharing towels. ... - Chicago Sun-Times,

Study Shows Superiority of Venetec's StatLock for Securing ...  Oct 24, 2005
...several different “novel technologies� concluded that StatLock significantly outperformed all other technologies, including chlorhexidine sponge dressing ... - Medical News Today (press release),

RA DRUG FOR PSORIASIS  Oct 18, 2005
The program to tackle MRSA infection included the use of alcohol/chlorhexidine hand wash solution before and after every patient contact, and the cleaning of ... - AustralianDoctor.com (subscription),

Basic steps could save 100,000 patients  Oct 5, 2005
...attacks. **Prevent infections from IV lines by, for example, washing hands and cleaning patients' skin with chlorhexidine soap. ... - Chicago Sun-Times,

Catheter-Related Bloodstream Infection Rates in a Pediatric ...  Oct 11, 2005
The team emphasized four elements to ensure the site remained sterile during the catheter placement -- hand hygiene, use of chlorhexidine instead of betadine ... - DG News

Sorted: DIY cosmetic dentistry  Oct 14, 2005
Mouthwash Mouthwashes that contain chlorhexidine have been proven to have some anti-plaque and anti-bacterial effect on your teeth. ... - Times Online,

Catheter-Related Bloodstream Infection Rates in a Pediatric ...  11 Oct 2005
The team emphasized four elements to ensure the site remained sterile during the catheter placement -- hand hygiene, use of chlorhexidine instead of betadine ... - DG News

Basic steps could save 100,000 patients  Oct 5, 2005
...attacks. **Prevent infections from IV lines by, for example, washing hands and cleaning patients' skin with chlorhexidine soap. ... - Chicago Sun-Times,

The Natural Dentist Introduces New Flavors Peppermint Twist And ...  Sep 20, 2005
Periodontists and other dental specialists recommend Natural Dentist Healthy Gums® as an alternative to the prescription product Chlorhexidine Gluconate (CHX ... - SocialFunds.com

Cat's ringworm will take some aggressive treatment to eradicate  Sep 10, 2005
The cat should be shaved, bathed one to two times a week with chlorhexidine, ketoconazole, or miconazole shampoos, and treated with topical antifungal agents. ... - DetNews.com,

Dosage Forms Oral rince; Pellet, extended- release; PerioChip (in a biodegradable matrix of hydrolyzed gelatin [cross-linked with glutaraldehyde]) (glycerin) (purified water); CREAM; DRESSING; GEL; LOTION; OINTMEN; SPONGE
Drug_Category Anti-bacterial Agents; Anti-Infectives; ATC:A01AB03; ATC:B05CA02; ATC:D08AC02; ATC:D09AA12; ATC:R02AA05; ATC:S01AX09; ATC:S02AA09; ATC:S03AA04
Absorption absorption of chlorhexidine from the gastrointestinal tract is very poor
Interactions Interactions for Chlorhexidine:

No information provided.

Toxicity LD50= 2g/kg (human, oral); LD50= 3 g/kg (rat, oral); LD50= 2.5 g/kg (mice, oral); LD50= 21 mg/kg (male rat, IV); LD50= 23 mg/kg (female rat, IV); LD50= 25 mg/kg (male mice, IV); LD50= 24 mg/kg (female mice, IV); LD50= 1g/kg (rat, subcutaneous); LD50= 637 mg/kg (male mice, subcutaneous); LD50= 632 mg/kg (female mice, subcutaneous)
Organisms Affected Enteric bacteria and other eubacteria
Chemical IUPAC Name 1-[amino-[6-[amino-[amino-(4-chlorophenyl)amino-methylidene]amino-methylidene]aminohexylimino]methyl]imino-N-(4-chlorophenyl)-methanediamine
Chemical Formula C22H30Cl2N10
Molecular Weight 505.446 g/mol
Smiles String C1=CC(=CC=C1NC(=NC(=NCCCCCCN=C(N)N=C(N)NC2=CC=C(C=C2)Cl)N)N)Cl
Melting Point 134 °C
Water Solubility 0.08%(w/v)
State Solid
LogP/Hphobicity 4.066
Isoelectric Point 10.8
Biotransformation Not Available
Half Life Not Available
Protein Binding [%] 87%
RxList Link RXlist
Sponsored links
Drug Reference http://www.drugs.com/cons/Chlorhexidine.html
http://www.rxlist.com/cgi/generic2/chlorhexidine.htm
Drug Type Approved Drug
Accession No APRD00545
CAS Registry Number 55-56-1
KEGG Compound ID C06902
PubChem ID SID:338074
PharmGKB ID PA448934
SwissProt ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] 2242329

Home | About | Cancers | Treatment | Medications
Copyright onconews.org 2005.
All Rights Reserved.
Google
 
Web onconews.org