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Chlordiazepoxide
drug data and news
Chlordiazepoxide drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Chlordiazepoxide | ||
| Brand Names/Synonyms | A-Poxide; Abboxide; Apo-Chlordiazepoxide; Balance; CD 2; CDO; CDP; Chloradiazepoxide; Chlordiazachel; Chlordiazepoxid; Chlordiazepoxide; Chlordiazepoxide Base; Chlordiazepoxide Hcl; Chlordiazepoxidum; Chloridazepoxide; Chloridiazepide; Chloridiazepoxide; Chlorodiazepoxide; Chlozepid; Clopoxide; Clordiazepossido; Contol; Control; Decacil; Eden; Elenium; Helogaphen; Ifibrium; Kalmocaps; Librax; Librelease; Librinin; Libritabs; Librium; Limbitrol; Limbitrol Ds; Lygen; Menrium; Mesural; Methaminodiazepoxide; Mildmen; Multum; Napoton; Napton; Novo-Poxide; Psicosan; Radepur; Risolid; Silibrin; Tropium; Viopsicol | ||
| Indication | For the management of anxiety disorders or for the short-term relief of symptoms of anxiety, withdrawal symptoms of acute alcoholism, and preoperative apprehension and anxiety. | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Chlordiazepoxide has antianxiety, sedative, appetite-stimulating and weak analgesic actions. The precise mechanism of action is not known. The drug blocks EEG arousal from stimulation of the brain stem reticular formation. The drug has been studied extensively in many species of animals and these studies are suggestive of action on the limbic system of the brain, which recent evidence indicates is involved in emotional responses. Hostile monkeys were made tame by oral drug doses which did not cause sedation. Chlordiazepoxide revealed a "taming" action with the elimination of fear and aggression. The taming effect of chlordiazepoxide was further demonstrated in rats made vicious by lesions in the septal area of the brain. The drug dosage which effectively blocked the vicious reaction was well below the dose which caused sedation in these animals. | ||
| Mechanism Of Action | Chlordiazepoxide binds to stereospecific benzodiazepine (BZD) binding sites on GABA (A) receptor complexes at several sites within the central nervous system, including the limbic system and reticular formation. BZDs enhance GABA-mediated chloride influx through GABA receptor channels, causing membrane hyperpolarization. The net neuro-inhibitory effects result in the observed sedative, hypnotic, anxiolytic, and muscle relaxant properties. | ||
| Chlordiazepoxide News (When available) |
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| Dosage Forms | CAPSULE (5 mg, 10 mg or 25 mg) | ||
| Drug_Category | Anti-anxiety Agents; Hypnotics and Sedatives; Adjuvants, Anesthesia; Benzodiazepines; GABA Modulators; ATC:N05BA02 | ||
| Absorption | Not Available | ||
| Interactions | Interactions for Chlordiazepoxide: Although clinical studies have not established a cause and effect relationship, physicians should be aware that variable effects an blood coagulation have been reported very rarely in patients receiving oral anticoagulants and chlordiazepoxide. The concomitant use of alcohol or other central nervous system depressants may have an additive effect. | ||
| Toxicity | Oral, rat LD50: 537 mg/kg. Signs of overdose include respiratory depression, muscle weakness, somnolence (general depressed activity). | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 10-chloro-3-hydroxy-N-methyl-2-phenyl-3,6-diazabicyclo[5.4.0]undeca-1,6,8,10-tetraen-5-imine | ||
| Chemical Formula | C16H14ClN3O | ||
| Molecular Weight | 299.755 g/mol | ||
| Smiles String | CN=C1CN(C(=C2C=C(C=CC2=N1)Cl)C3=CC=CC=C3)O | ||
| Melting Point | 236.2 °C | ||
| Water Solubility | 2000 mg/L | ||
| State | Solid | ||
| LogP/Hphobicity | 2.853 | ||
| Isoelectric Point | 4.8 | ||
| Biotransformation | Hepatic. | ||
| Half Life | 24-48 hours | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Chlordiazepoxide.html http://www.rxlist.com/cgi/generic/chlordia.htm http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/lib1225.shtml | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00682 | ||
| CAS Registry Number | 58-25-3 | ||
| KEGG Compound ID | C06901 | ||
| PubChem ID | SID:148862 | ||
| PharmGKB ID | PA448932 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 156590 |
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