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Chlorambucil
drug data and news
Chlorambucil drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Chlorambucil | ||
| Brand Names/Synonyms | Ambochlorin; Amboclorin; CB 1348; Cb L348; Chlocambucil; Chlorambucil; Chloraminophen; Chloraminophene; Chlorbutin; Chlorbutine; Chloroambucil; Chlorobutin; Chlorobutine; Ecloril; Elcoril; Leukeran; Leukeran Tablets; Leukersan; Leukoran; Linfolizin; Linfolysin; NSC 3088; Pepstatin; Phenylbuttersaeure-Lost; Phenylbutyric Acid Nitrogen Mustard; Rcra Waste Number U035 | ||
| Indication | For treatment of chronic lymphatic (lymphocytic) leukemia, malignant lymphomas including lymphosarcoma, giant follicular lymphoma, and Hodgkin's disease | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Chlorambucil is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Alkylating agents are cell cycle-nonspecific. Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death. | ||
| Mechanism Of Action | Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their attempts to replace the alkylated bases, preventing DNA synthesis and RNA transcription from the affected DNA, 2) DNA damage via the formation of cross-links (bonds between atoms in the DNA) which prevents DNA from being separated for synthesis or transcription, and 3) the induction of mispairing of the nucleotides leading to mutations. | ||
| Chlorambucil News (When available) |
Am J Pathology (subscription) ...lymphocytes. Pretreatment with NS-398 significantly potentiated the cytotoxicity induced by chlorambucil in 8 of 16 B-CLL samples examined. ... | ||
| Dosage Forms | TABLET | ||
| Drug_Category | Antineoplastic Agents; ATC:L01AA02 | ||
| Absorption | Not Available | ||
| Interactions |
Interactions for Chlorambucil: There are no known drug/drug interactions with chlorambucil. | ||
| Toxicity | Not Available | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 4-[4-[bis(2-chloroethyl)amino]phenyl]butanoicacid | ||
| Chemical Formula | C14H19Cl2NO2 | ||
| Molecular Weight | 304.212 g/mol | ||
| Smiles String | C1=CC(=CC=C1CCCC(=O)O)N(CCCl)CCCl | ||
| Melting Point | 65 °C | ||
| Water Solubility | 1.24E+004 mg/L | ||
| State | Solid | ||
| LogP/Hphobicity | 3.25 | ||
| Isoelectric Point | 5.75 | ||
| Biotransformation | Not Available | ||
| Half Life | 1.5 hours | ||
| Protein Binding [%] | 99% | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Chlorambucil.html http://www.rxlist.com/cgi/generic2/leukeran.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00115 | ||
| CAS Registry Number | 305-03-3 | ||
| KEGG Compound ID | C06900 | ||
| PubChem ID | SID:152571 | ||
| PharmGKB ID | PA448926 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 4626 |
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