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Cetuximab
drug data and news
Cetuximab drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Cetuximab | ||
| Brand Names/Synonyms | Ig gamma-1 chain C region; Anti EGFR; Erbitux (ImClone Systems Inc) | ||
| Indication | For treatment of metastatic colorectal cancer | ||
| Sponsored links | Description | Epidermal growth factor receptor binding FAB. Cetuximab is composed of the Fv (variable; antigen-binding) regions of the 225 murine EGFr monoclonal antibody specific for the N-terminal portion of human EGFr with human IgG1 heavy and kappa light chain constant (framework) regions. | |
| Pharmacology | Used in the treatment of colorectal cancer, Erbitux binds specifically to the epidermal growth factor receptor (EGFr, HER1, c-ErbB-1) on both normal and tumor cells. EGFr is over-expressed in many colorectal cancers. Erbitux competitively inhibits the binding of epidermal growth factor (EGF) and other ligands, such as transforming growth factor–alpha. Binding of Erbitux to the EGFr blocks phosphorylation and activation of receptor-associated kinases, resulting in inhibition of cell growth, induction of apoptosis, decreased matrix metalloproteinase secretion and reduced vascular endothelial growth factor production. | ||
| Mechanism Of Action | Erbitux binds to the epidermal growth factor receptor (EGFr) on both normal and tumor cells. EGFr is over-expressed in many colorectal cancers. Erbitux competitively inhibits the binding of epidermal growth factor (EGF) and TGF alpha, thereby reducing their effects on cell growth and metastatic spread. | ||
| Cetuximab News (When available) |
Searching for Osteoarthritis Pain Relief? 06 Mar 2006 Expert Warns of Overuse of Over-the-Counter Pain Medication 06 Mar 2006 Group seeks federal ban on Darvocet Feb 28, 2006 Watchdog group seeks federal ban on Darvocet and related ... Feb 28, 2006 Darvocet, Others Should Be Off Market, Group Says Feb 28, 2006 Group Seeks Federal Ban on Darvocet Feb 28, 2006 Health briefs Mar 5, 2006 Group Seeks Federal Ban on Darvocet Feb 28, 2006 Group Seeks Federal Ban on Darvocet Feb 28, 2006 Darvocet, Others Should Be Off Market, Group Says Feb 28, 2006 EEO Public File Report Mar 2, 2006 Ban Sought On Some Painkillers Feb 28, 2006 Group Blames Darvon for Thousands of Deaths, Seeks Ban Mar 1, 2006 Pain drug too deadly, group says Feb 28, 2006 Group asks FDA to phase out Darvon Feb 28, 2006 Consumer Watchdog Group, Public Citizen, Petitions FDA to Ban All ... Mar 1, 2006 Group Seeks Ban on Some Painkillers Feb 28, 2006 Group Says Some Painkillers Should Be Banned Feb 28, 2006 Public Citizen Demands FDA to Ban Darvon Products Feb 28, 2006 Arthritis Blog Archives Mar 1, 2006 Popular painkiller linked to 2000 deaths Mar 1, 2006 PAINKILLERS KILL PEOPLE, TOO: CRITICS Mar 1, 2006 'Take Darvon and generic versions off US market', FDA petitioned Mar 1, 2006 Ban Darvon and Related Painkillers: Public Citizen Mar 1, 2006 Group urges Darvon, others be phased out Mar 1, 2006 Drug-addicted doctor sent back to prison for 2 years Feb 23, 2006 Greer sentenced to two more years in prison Feb 22, 2006 US group petitions FDA to ban pain drug Feb 28, 2006 UPDATE 1-US group petitions FDA to ban pain drug Feb 28, 2006 Public Citizen Petitions FDA to Ban Darvon Feb 28, 2006 Cato Daily Dispatch for March 1, 2006 Mar 1, 2006 Fremont man arrested on drug charges Feb 16, 2006 Brad Garrett stands up Feb 21, 2006 Doctor headed back to court over drugs Feb 22, 2006 NEWS DIGEST Feb 25, 2006 Caution needed to prevent accidental acetaminophen overdose Feb 4, 2006 Pastor facing charges Feb 11, 2006 Minister Poses As Doctor To Get Prescription Painkillers Feb 10, 2006 Two Indiana men plead guilty of anhydrous ammonia theft Feb 3, 2006 | ||
| Dosage Forms | Not Available | ||
| Drug_Category | Antineoplastic Agents | ||
| Absorption | Not Available | ||
| Interactions | Not Available | ||
| Toxicity | Not Available | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | Humanized anti-EGF receptor (EGFr) antibody | ||
| Chemical Formula | C6484H10042N1732O2023S36 >Anti-EGFR light chain 1 >Anti-EGFR heavy chain 2 >Anti-EGFR light chain 2 | ||
| Molecular Weight | 145781.6 | ||
| Smiles String | Not Available | ||
| Melting Point | 61 oC (FAB fragment), 71 oC (whole mAb) - Vermeer, A.W.P. & Norde, W., Biophys. J. 78:394-404 (2000). | ||
| Water Solubility | Not Available | ||
| State | Transparent, slightly viscous, aqueous liquid | ||
| LogP/Hphobicity | -0.413 | ||
| Isoelectric Point | 8.48 | ||
| Biotransformation | Not Available | ||
| Half Life | 114 hrs | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Cetuximab.html http://www.rxlist.com/cgi/generic3/erbitux.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | BIOD00071 | ||
| CAS Registry Number | 205923-56-4 | ||
| KEGG Compound ID | Not Available | ||
| PubChem ID | Not Available | ||
| PharmGKB ID | PA10040 | ||
| SwissProt ID | IGHG1_HUMAN (P01857) | ||
| GenBank ID | J00228 | ||
| Drug ID Number [DIN] | Not Available |
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