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Cetirizine
drug data and news
Cetirizine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Cetirizine | ||
| Brand Names/Synonyms | Alerlisin; CHEMBANK1856; Cetirizina [Spanish]; Cetirizine; Cetirizinum [Latin]; Cetrizine Hcl; Cetryn; Formistin; Hitrizin Film Tablet; Reactine; Setir; Virlix; Ziptek; Zirtek; Zyrlex; Zyrtec | ||
| Indication | For the relief of symptoms associated with seasonal allergic rhinitis, perennial allergic rhinitis and the treatment of the uncomplicated skin manifestations of chronic idiopathic urticaria | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Cetirizine, the active metabolite of the piperazine H1-receptor antagonist hydroxyzine, is used to treat chronic idiopathic urticaria, perennial allergic rhinitis, seasonal allergic rhinitis, allergic asthma, physical urticaria, and atopic dermatitis. | ||
| Mechanism Of Action | Cetirizine competes with histamine for binding at H1-receptor sites on the effector cell surface, resulting in suppression of histaminic edema, flare, and pruritus. The low incidence of sedation can be attributed to reduced penetration of cetirizine into the CNS as a result of the less lipophilic carboxyl group on the ethylamine side chain. | ||
| Cetirizine News (When available) |
HUGIN NEWS/UCB Receives EMEA Positive Opinion and FDA Approvable ... Feb 2, 2006 Epilepsy - UCB Receives EMEA Positive Opinion And FDA Approvable ... Feb 5, 2006 You may not be able to find your favorite decongestant Dec 6, 2005 New Therapies on the Horizon for Allergic Rhinitis Nov 30, 2005 UCB's Anti-Epileptic Keppra(R) Meets Primary End-Point in ... Sep 15, 2005 UCB's Anti-Epileptic Keppra(R) Meets Primary End-Point in ... Sep 15, 2005 Many meds don't mix with the sun Sep 21, 2005 Study: Herb helps hay fever Aug 22, 2005 Butterbur: leaf extract yields positive hayfever results Aug 22, 2005 Complications From Olanzapine in a Mentally Healthy Patient Aug 31, 2005 Old wine in new bottles Aug 28, 2005 Certolizumab pegol, positive results in two Phase III Crohn'™s ... Jul 26, 2005 Certolizumab Pegol Demonstrates Positive Results in Two Phase III ... Jul 26, 2005 Certolizumab Pegol Demonstrates Positive Results in Two Phase III ... Jul 27, 2005 Over the counter: antihistamines Jul 8, 2005 Allergy skin tests: Identify the sources of your sneezing Jul 11, 2005 Allergy skin tests: Identify the sources of your sneezing 11 Jul 2005 Over the counter: antihistamines Jul 8, 2005 FDA Approves UCB's Keppra(R) for Use in Childhood Epilepsy Jun 27, 2005 A Question Of Health Jun 28, 2005 Fewer Prescriptions, Lower Costs Follow Claritin's OTC Switch, USA Jun 12, 2005 FDA Approves UCB's Keppra(R) for Use in Childhood Epilepsy Jun 24, 2005 Allergy medications: Know your options Jun 25, 2005 FDA Approves UCB's Keppra(R) for Use in Childhood Epilepsy 13 Sep 2002 FDA Approves UCB's Keppra(R) for Use in Childhood Epilepsy Jun 24, 2005 Allergy medications: Know your options Jun 25, 2005 Fewer Prescriptions, Lower Costs Follow Claritin's OTC Switch, USA Jun 12, 2005 What Makes a Drug "OTC"? The Case of Plan B Jun 3, 2005 FDA Sends Pfizer Warning Letter Over Zyrtec Advertisements Apr 26, 2005 Allergies: The new anti-aphrodisiac Apr 7, 2005 Itching for Some Allergy Relief? Apr 1, 2005 Health Northwest: Dealing with springtime allergies Mar 25, 2005 Hives : Skin Problems : Causes, Cure and Removal. Mar 23, 2005 | ||
| Dosage Forms | tablets | ||
| Drug_Category | Anti-allergic Agents; Antihistamines; ATC:R06AE07; ATC:R06AE09 | ||
| Absorption | mean peak plasma concentration (Cmax) of 114 ng/mL at a time (Tmax) of 2.2 hours postdose was observed for cetirizine | ||
| Interactions |
Interactions for Cetirizine: Pharmacokinetic interaction studies with cetirizine in adults were conducted with pseudoephedrine, antipyrine, ketoconazole, erythromycin and azithromycin. No interactions were observed. In a multiple dose study of theophylline (400 mg once daily for 3 days) and cetirizine (20 mg once daily for 3 days), a 16% decrease in the clearance of cetirizine was observed. The disposition of theophylline was not altered by concomitant cetirizine administration. Drug-Drug Interactions: No clinically significant drug interactions have been found with theophylline at a low dose, azithromycin, pseudoephedrine, ketoconazole, or erythromycin. There was a small decrease in the clearance of cetirizine caused by a 400-mg dose of theophylline; it is possible that larger theophylline doses could have a greater effect. | ||
| Toxicity | Somnolence (sleepiness or unusual drowsiness), restlessness, irritability | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]aceticacid | ||
| Chemical Formula | C21H25ClN2O3 | ||
| Molecular Weight | 388.888 g/mol | ||
| Smiles String | C1CN(CCN1CCOCC(=O)O)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl | ||
| Melting Point | 110-115°C | ||
| Water Solubility | 101 mg/L | ||
| State | solid | ||
| LogP/Hphobicity | 3.238 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Not Available | ||
| Half Life | 8.3 hours | ||
| Protein Binding [%] | Very high (93%) plasma protein binding | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Cetirizine.html http://www.rxlist.com/cgi/generic/cetiriz.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00630 | ||
| CAS Registry Number | 83881-51-0 | ||
| KEGG Compound ID | C07778 | ||
| PubChem ID | SID:192657 | ||
| PharmGKB ID | Not Available | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2240910 |
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