Ceftriaxone drug data and news

Ceftriaxone drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name

Ceftriaxone

Brand Names/Synonyms

Biotrakson; Cefatriaxone; Ceftriaxona [Inn-Spanish]; Ceftriaxone; Ceftriaxone [Usan:Jan]; Ceftriaxone and Dextrose in Duplex Container; Ceftriaxonum [Inn-Latin]; Ceftriazone; DRG-0071; Rocephin; Rocephine

Indication

For the treatment of the infections (respiratory, skin, soft tissue, UTI, ENT) caused by S. pneumoniae, H. influenzae, staphylococci, S. pyogenes (group A beta-hemolytic streptococci), E. coli, P. mirabilis, Klebsiella sp, coagulase-negative staph

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Description

Not Available

Pharmacology

Ceftriaxone is a cephalosporin/cephamycin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. Ceftriaxone has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Ceftriaxone results from the inhibition of cell wall synthesis and is mediated through Ceftriaxone binding to penicillin binding proteins (PBPs). Ceftriaxone is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases.

Mechanism Of Action

Ceftriaxone works by inhibiting the mucopeptide synthesis in the bacterial cell wall. The beta-lactam moiety of Ceftriaxone binds to carboxypeptidases, endopeptidases, and transpeptidases in the bacterial cytoplasmic membrane. These enzymes are involved in cell-wall synthesis and cell division. By binding to these enzymes, Ceftriaxone results in the formation of of defective cell walls and cell death.

Ceftriaxone News
(When available)

American Pharma Gets Ceftriaxone FDA OK Feb 16, 2006
The company received marketing approval for 250 milligram, 500 milligram, 1 gram and 2 gram single-dose vials of injectable ceftriaxone and for a 10 gram ... - Houston Chronicle,

American Pharmaceutical Partners Receives Two FDA Approvals for ... Feb 16, 2006
...it has received two approvals from the US Food and Drug Administration (FDA) for its Abbreviated New Drug Applications (ANDAs) for Ceftriaxone for Injection ... - International News Service,

American Pharmaceutical Partners Receives Two FDA Approvals for ... Feb 16, 2006
Cephalosporins * With 17 Products, APP has the Largest Anti-Infectives Portfolio in the Generic Injectables Industry * APP to Supply Ceftriaxone in Bar-Coded ... - PR Newswire (press release),

Buy Orchid Chemicals; growth unfolding: Edelweiss Sec Feb 26, 2006
As demonstrated by the approval of ceftriaxone vials, Orchid’s established strength in the antibiotics area helps it get approvals faster.�?. ... - Moneycontrol.com,

Getting healthier Feb 19, 2006
It has developed a fixed dose combination (FDC) of ceftriaxone, which has become a Rs 70 crore brand in seven months of launch and is expected to become a Rs ... - Business Standard,

MSF leads a campaign to vaccinate 100,000 people in southern ... Feb 19, 2006
...began working with the Ethiopian Ministry of Health to respond to this epidemic, providing medications (oily chloramphenicol and Ceftriaxone) and treatment ... - Reuters AlertNet,

Extraintestinal Salmonella Infection Appearing as a Suspicious ... Feb 9, 2006
The patient was admitted and treated with parenteral ceftriaxone. ... Repeated blood cultures were sterile. The ceftriaxone was continued for 1 additional week. ... - Journal of Ultrasound in Medicine

(PRN) - Focus Media to Announce Fourth Quarter and Full Year 2005 ... Feb 16, 2006
...(PRN) - American Pharmaceutical Partners Receives Two FDA Approvals for Ceftriaxone for Injection, USP, Maintaining Company's Leadership Position in the ... - Bolsamania.com,

Article presents epidemiology of typhoid fever in Mauritius Feb 16, 2006
...preventive measures. Ceftriaxone should be used as the initial first-line treatment of infection acquired in India.". Issack published ... - TMCnet

Record year for Roche's pharma unit Feb 1, 2006
25%, four times as fast as the global market and despite the loss of patent armour for Roche's one-time best-seller, the antibiotic Rocephin (ceftriaxone). ... - Pharma Times (subscription),

Dosage Forms

Dosage Forms:IV Infusion;

Drug_Category

Anti-bacterial Agents; Cephalosporins; ATC:J01DD04

Absorption

Not Available

Interactions

Interactions for Ceftriaxone:

No information provided.

Toxicity

Not Available

Organisms Affected

Enteric bacteria and other eubacteria

Chemical IUPAC Name

8-[2-(2-amino-1,3-thiazol-4-yl)-2-methoxyimino-acetyl]amino-4-[(2-methyl-5,6-dioxo-1H-1,2,4-triazin-3-yl)sulfanylmethyl]-7-oxo-2-thia-6-azabicyclo[4.2.0]oct-4-ene-5-carboxylic acid

Chemical Formula

C18H18N8O7S3

Molecular Weight

554.583 g/mol

Smiles String

CN1C(=NC(=O)C(=O)N1)SCC2=C(N3C(C(C3=O)NC(=O)C(=NOC)C4=CSC(=N4)N)SC2)C(=O)O

Melting Point

>155 °C

Water Solubility

Not Available

State

Solid

LogP/Hphobicity

-1.341

Isoelectric Point

Not Available

Biotransformation

Not Available

Half Life

5.8-8.7 hours

Protein Binding [%]

95%

RxList Link

RXlist

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Drug Reference

http://www.drugs.com/cons/Ceftriaxone.html
http://www.rxlist.com/cgi/generic3/ceftriax.htm

Drug Type

Approved Drug

Accession No

APRD00395

CAS Registry Number

73384-59-5

KEGG Compound ID

C06683

PubChem ID

SID:189949

PharmGKB ID

PA448866

SwissProt ID

Not Available

GenBank ID

Not Available

Drug ID Number [DIN]

657409