Cefprozil drug data and news

Cefprozil drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name

Cefprozil

Brand Names/Synonyms

Arzimol; Brisoral; Cefprozil anhydrous; Cefprozilo [INN-Spanish]; Cefprozilum [INN-Latin]; Cefzil; Cronocef; Procef; Serozil

Indication

For the treatment of the following infections (respiratory, skin, soft tissue, UTI, ENT) caused by; S. pneumoniae, H. influenzae, staphylococci, S. pyogenes (group A beta-hemolytic streptococci), E. coli, P. mirabilis, Klebsiella sp, coagulase-negative staph

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Description

Not Available

Pharmacology

Cefprozil, a semisynthetic, second-generation cephalosporin, is used to treat otitis media, soft-tissue infections, and respiratory tract infections.

Mechanism Of Action

Cefprozil, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefprozil interferes with an autolysin inhibitor.

Cefprozil News
(When available)

Par Pharmaceutical Reports Sales and Earnings for 2005 Feb 28, 2006
...generic version of Adoxa(R) licensed from Bradley Pharmaceuticals, Inc.; and - Par received final FDA approval and began shipping cefprozil tablets, cefprozil ... - MSN Money

Lupin hunts for brand buyouts in US, Europe Feb 3, 2006
The company launched five products in the US market in the last quarter, which included Cefprozil suspension and tablets on patent expiry. - Daily News & Analysis,

Orchid receives USFDA nod for Cefprozil tablets Jan 24, 2006
...based pharma major, Orchid Chemicals & Pharmaceuticals announced that it has received the formal approval from the USFDA for its ANDA for Cefprozil tablets USP ... - Express Pharma Pulse,

Third-quarter earnings perk up Lupin by 5% Jan 30, 2006
...investment of Rs 26 crore. Lupin launched five products in the US market in the quarter, which included Cefprozil suspension and tablets. - Business Standard,

First-Time Generic Approvals: Zithromax, Cefzil, Zonegran Jan 27, 2006
...the treatment of community-acquired pneumonia and for pelvic inflammatory disease caused by susceptible strains of designated microorganisms; cefprozil 125-mg/5 ... - Medscape (subscription)

Orchid Q3 turnover up Jan 19, 2006
The growth momentum of the second quarter (Q2) has been sustained with the ramp-up of Ceftriaxone injection and introduction of Cefprozil tablets and ... - Webindia123,

for Oral Suspension Jan 18, 2006
...recently announced that it had received final approval from the FDA for its Abbreviated New Drug Application for cefprozil for oral suspension. ... - Pharmaceutical Processing,

Orchid gets USFDA nod for Cefoxitin Jan 27, 2006
Director K Raghavendra Rao. The current US market size for Cefprozil tablets is estimated at 117 million dollars. This is the eighth ... - NewKerala.com,

Zacks.com Announces That Vivian Lewis Highlights the Following ... Jan 17, 2006
C virus. It also won FDA ok for cefprozil in tablet and oral form, and oxydine in 3 doses including extended release. Successful ... - Business Wire (press release),

FDA approves Teva antibiotic Cefprozil 11 Dec 2005
...has announced that the US Food and Drug Administration has granted approval for the its ANDAs (abbreviated new drug applications) for Cefprozil Tablets USP ... - Globes,

Real growth will happen from 2007: Orchid Dec 10, 2005
Two more are to be introduced shortly, once the approvals are got - Cefprozil, whose patent expires on December 23 and Cefoxitin, patent of which has expired. ... - Sify,

Dongkuk Steel, Hon Hai, Hyundai: Asia Ex-Japan Equity Preview Dec 9, 2005
Co.'s antibiotic Cefzil in the US Lupin won approval from the Food and Drug Administration to sell 250- and 500-milligram tablets of cefprozil, the company ... - Bloomberg

Orchid to unveil 2 more antibiotics in US Aug 17, 2005
130 crore) this year. Cefprozil, a cephalosporin, is to lose its patent protection in the US in December 2005. Orchid expects to ... - Sify,

Orchid Chemicals to launch two more antibiotics in US Aug 17, 2005
...according to sources. Cefprozil, a cephalosporin, is to lose its patent protection in the US in December 2005. Orchid expects to ... - Myiris.com,

Orchid announces 1:2 bonus Jul 18, 2005
Speaking on the marketing plans, Narayanan said Orchid's two premium products Ceftraixone and Cefprozil, which will become off patent this fiscal, has a ... - Newindpress

USFDA inspects Orchid Pharma Mar 7, 2005
The ANDAs reviewed in the inspection include blockbuster products such as Ceftriaxone injectabte and Cefprozil oral dosage forms, going off-patent in July 2005 ... - Economic Times,

Dosage Forms

Cefzil tablets contain cefprozil equivalent to 250 mg or 500 mg of anhydrous cefprozil.

Drug_Category

Anti-bacterial Agents; Cephalosporins; ATC:J01DC10

Absorption

Oral_~95%

Interactions

Nephrotoxicity has been reported following concomitant administration of aminoglycoside antibiotics and cephalosporin antibiotics. Concomitant administration of probenecid doubled the AUC for cefprozil. The bioavailability of the capsule formulation of cefprozil was not affected when administered 5 minutes following an antacid.

Toxicity

Single 5000 mg/kg oral doses of cefprozil caused no mortality or signs of toxicity in adult, weaning or neonatal rats, or adult mice. A single oral dose of 3000 mg/kg caused diarrhea and loss of appetite in cynomolgus monkeys, but no mortality.

Organisms Affected

Enteric bacteria and other eubacteria

Chemical IUPAC Name

8-[2-amino-2-(4-hydroxyphenyl)-acetyl]amino-7-oxo-4-prop-1-enyl-2-thia-6-azabicyclo[4.2.0]oct-4-ene-5-carboxylicacid

Chemical Formula

C18H19N3O5S

Molecular Weight

389.427 g/mol

Smiles String

CC=CC1=C(N2C(C(C2=O)NC(=O)C(C3=CC=C(C=C3)O)N)SC1)C(=O)O

Melting Point

218-225°C

Water Solubility

55 mg/L

State

white or yellowish powder

LogP/Hphobicity

0.209

Isoelectric Point

Not Available

Biotransformation

Cefprozil is eliminated primarily by the kidneys

Half Life

1.3 hours

Protein Binding [%]

36%

RxList Link

RXlist

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Drug Reference

http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/cef1077.shtml
http://www.drugs.com/cons/Cefprozil.html
http://www.rxlist.com/cgi/generic/cefprozi.htm

Drug Type

Approved Drug

Accession No

APRD00461

CAS Registry Number

92665-29-7

KEGG Compound ID

C06888

PubChem ID

SID:205164

PharmGKB ID

PA448860

SwissProt ID

Not Available

GenBank ID

Not Available

Drug ID Number [DIN]

2163667