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Cefadroxil
drug data and news
Cefadroxil drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Cefadroxil | ||
| Brand Names/Synonyms | Baxan; Bidocef; CDX; Cefa-Drops; Cefadroxil; Cefadroxil Micronised Powder; Cefadroxil Monohydrate; Cefamox; Ceforal; Cefradroxil; Cephos; Duracef; Duricef; Kefroxil; Oracefal; Sedral; Sumacef; Ultracef | ||
| Indication | For the treatment of the following infections (skin, UTI, ENT) caused by; S. pneumoniae, H. influenzae, staphylococci, S. pyogenes (group A beta-hemolytic streptococci), E. coli, P. mirabilis, Klebsiella sp, coagulase-negative staphylococci and Staphylococcu | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Cefadroxil, a first-generation cephalosporin antibiotic, is used to treat urinary tract infections, skin and skin structure infections, pharyngitis, and tonsillitis. | ||
| Mechanism Of Action | Like all beta-lactam antibiotics, cefadroxil binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, causing the inhibition of the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefadroxil interferes with an autolysin inhibitor. | ||
| Cefadroxil News (When available) |
Antibiotics keep blood bacteria-free Sep 27, 2005 | ||
| Dosage Forms | Cefadroxil comes as a capsule, tablet, and liquid to take by mouth | ||
| Drug_Category | Anti-bacterial Agents; Cephalosporins; ATC:J01DB05 | ||
| Absorption | Cefadroxil is well absorbed on oral administration; food does not interfere with the absorption | ||
| Interactions |
-->Interactions for Cefadroxil: Drug/Laboratory Test Interactions Positive direct Coombsí tests have been reported during treatment with the cephalosporin antibiotics. In hematologic studies or in transfusion cross-matching procedures when anti-globulin tests are performed on the minor side or in Coombsí testing of newborns whose mothers have received cephalosporin antibiotics before parturition, it should be recognized that a positive Coombsí test may be due to the drug. | ||
| Toxicity | Nausea, vomiting, diarrhoea, allergic rashes may occur | ||
| Organisms Affected | Enteric bacteria and other eubacteria | ||
| Chemical IUPAC Name | 8-[2-amino-2-(4-hydroxyphenyl)-acetyl]amino-4-methyl-7-oxo-2-thia-6-azabicyclo[4.2.0]oct-4-ene-5-carboxylicacid | ||
| Chemical Formula | C16H17N3O5S | ||
| Molecular Weight | 363.389 g/mol | ||
| Smiles String | CC1=C(N2C(C(C2=O)NC(=O)C(C3=CC=C(C=C3)O)N)SC1)C(=O)O | ||
| Melting Point | 197°C | ||
| Water Solubility | 1110 mg/L | ||
| State | Solid | ||
| LogP/Hphobicity | -0.355 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Not Available | ||
| Half Life | 1.5 h | ||
| Protein Binding [%] | binding rates of cefadroxil were 28.1% by U.F. method | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Cefadroxil.html http://www.rxlist.com/cgi/generic/cefadrox.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00196 | ||
| CAS Registry Number | 66592-87-8 | ||
| KEGG Compound ID | C06878 | ||
| PubChem ID | SID:180636 | ||
| PharmGKB ID | Not Available | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2240774 |
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