Cefaclor drug data and news

Cefaclor drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name

Cefaclor

Brand Names/Synonyms

Alenfral; Alfacet; Alfatil; CCL; Ceclor; Ceclor Cd; Cefaclor; Cefaclor Anhydrous; Cefaclorum; Cefaclorum [Inn-Latin]; Cephaclor; Distaclor; Kefral; Kefral, Raniclor; Panacef; Panoral; Raniclor; S 6472

Indication

For the treatment of the following infections (respiratory, skin, soft tissue, UTI, ENT) caused by; S. pneumoniae, H. influenzae, staphylococci, S. pyogenes (group A ß-hemolytic streptococci), E. coli, P. mirabilis, Klebsiella sp, coagulase-negative staph

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Description

Not Available

Pharmacology

Cefaclor, a second generation cephalosporin with a spectrum resembling first-generation cephalosporins, is used to treat otitis media, sinusitis, and upper respiratory tract infection caused by ampicillin or amoxicillin-resistant H. influenzae. Alsos used to treat ear, lung, skin, throat, and urinary tract infections.

Mechanism Of Action

Cefaclor, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins. It is possible that cefaclor interferes with an autolysin inhibitor.

Cefaclor News
(When available)

Second mix-up at pharmacy Jan 31, 2006
...try another antibiotic. He prescribed cefaclor, dispensed as ceclor, and City Health Pharmacy filled the prescription. After three ... - Manawatu Standard,

Preserving Competition, FTC Requires Divestitures Before Allowing ... Jan 23, 2006
...to develop and market the following generic drugs: 1) amoxicillin clavulanate potassium from IVAX, to be divested to Par; 2) long-acting cefaclor (cefaclor LA ... - PharmaLive.com (press release),

Assignments of Intellectual Property are Within Competition Act’ ... Nov 21, 2005
Inc. in 1997 claiming that Apotex breached their patents over certain intermediates used to make the antibiotic Cefaclor. Apotex ... - Mondaq News Alerts,

Federal Court of Appeal Confirms Application of Competition Act to ... Nov 15, 2005
...infringement of eight patents related to intermediate compounds and processes for preparing intermediates useful in the production of the antibiotic cefaclor. ... - Mondaq News Alerts,

Canada Patent Ruling Curbs Competition Enforcement, Lawyer Says Sep 27, 2005
...to limit competition in Canada for the antibiotic cefaclor. Lilly obtained patents from Shionogi on the manufacturing processes for the drug. ... - Bloomberg

Eli Lilly at center of Canadian patent suit Sep 28, 2005
Japanese drugmaker Shionogi & Co. to limit competition in Canada for the antibiotic Cefaclor. Indianapolis-based Lilly obtained ... - Indianapolis Star,

Through the golden years: A Grandparent’s Day special Sep 10, 2005
Essential medicines such as antibiotics (amoxicillin, cefaclor, cephalexin, erythromycin, and co-trimoxazole), as well as those for tuberculosis ... - ABS CBN News,

Cheap branded drugs soon available in Botika ng Bayan Sep 9, 2005
Included in GSK’s Value Health list are the company’s bestsellers, salbutamol (for asthma), antibiotics (amoxicillin, cefaclor, cephalexin, erythromycin ... - INQ7 Interactive, Inc.,

Drug firms pop the pill for entry into global big league Jul 31, 2005
...study said. For instance, Ranbaxy is the world’s second largest manufacturer of cefaclor, the top-selling antibiotic. Lupin is ... - Calcutta Telegraph

Patents And Competition Jul 15, 2005
Each of the Shionogi patents described and claimed processes suitable for making intermediates which could be converted to the antibiotic cefaclor using non ... - Mondaq News Alerts <**results**>

Activation of Vagal Afferents in the Rat Duodenum By Protein ... Jun 18, 2005
Duodenal infusion with Cefaclor, a substrate of PepT1, increased duodenal vagal afferent activity; Cefaclor and protein hydrolysates selectively activated CCK ... - RedNova.com,

Dosage Forms

CAPSULE; POWDER; POWDER FOR SOLUTION; POWDER FOR SUSPENSION; SUSPENSION

Drug_Category

Anti-bacterial Agents; Cephalosporins; ATC:J01DC04

Absorption

Well absorbed after oral administration, independent of food intake

Interactions

Interactions for Cefaclor:

No information provided.

Toxicity

Side effects include paresthesias, mausea, vomiting, diarrhea, anorexia, abdominal pain, flatulence, pseudomembranous colitis, liver toxicity

Organisms Affected

Enteric bacteria and other eubacteria

Chemical IUPAC Name

8-(2-amino-2-phenyl-acetyl)amino-4-chloro-7-oxo-2-thia-6-azabicyclo[4.2.0]oct-4-ene-5-carboxylicacid

Chemical Formula

C15H14ClN3O4S

Molecular Weight

367.808 g/mol

Smiles String

C1C(=C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=CC=C3)N)C(=O)O)Cl

Melting Point

327 °C

Water Solubility

8.6 mg/mL

State

Solid

LogP/Hphobicity

0.517

Isoelectric Point

Not Available

Biotransformation

The cephalosporins do not undergo appreciable biotransformation in liver except cephalothin, cephapirin and cefotaxime. Thus, they are eliminated by kidney in unchanged form by glomerular filtration and tubular secretion

Half Life

0.6-0.9 hour

Protein Binding [%]

23.50%

RxList Link

RXlist

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Drug Reference

http://www.drugs.com/cons/Cefaclor.html
http://www.rxlist.com/cgi/generic/cefaclor.htm

Drug Type

Approved Drug

Accession No

APRD00243

CAS Registry Number

53994-73-3

KEGG Compound ID

C06877

PubChem ID

SID:181752

PharmGKB ID

PA448833

SwissProt ID

Not Available

GenBank ID

Not Available

Drug ID Number [DIN]

2237730