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Carmustine
drug data and news
Carmustine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Carmustine | ||
| Brand Names/Synonyms | BCNU; Becenun; Bi Cnu; Bicnu; Bischlorethylnitrosourea; Bischlorethylnitrosurea; Carmubris; Carmustin; Carmustine; FDA 0345; Gliadel; Gliadel Wafer; Nitrumon; SRI 1720 | ||
| Indication | For the treatment of brain tumors, multiple myeloma, Hodgkin's disease and Non-Hodgkin's lymphomas. | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Carmustine is one of the nitrosoureas indicated as palliative therapy as a single agent or in established combination therapy with other approved chemotherapeutic agents in treatment of brain tumors, multiple myeloma, Hodgkin's disease, and non-Hodgkin's lymphomas. Although it is generally agreed that Carmustine alkylates DNA and RNA, it is not cross resistant with other alkylators. As with other nitrosoureas, it may also inhibit several key enzymatic processes by carbamoylation of amino acids in proteins. | ||
| Mechanism Of Action | Carmustine causes cross-links in DNA and RNA, leading to the inhibition of DNA synthesis, RNA production and RNA translation (protein synthesis). Carmustine also binds to and modifies (carbamoylates) glutathione reductase. This leads to cell death. | ||
| Carmustine News (When available) |
MGI PHARMA To Present at the Lehman Brothers 9th Annual Global ... Mar 3, 2006 CANCER WONDER DRUGS BLOCKED Feb 25, 2006 Doctors demand brain tumour drugs Feb 22, 2006 NHS watchdog 'ignoring cancer patients' needs' Feb 23, 2006 Cancer specialists hail "big breakthroughs" in brain tumour ... Feb 23, 2006 Docs lobby minister over cancer drug Feb 23, 2006 CORRECTING and REPLACING MGI PHARMA Reports Fourth Quarter and ... Feb 9, 2006 CORRECTING and REPLACING MGI PHARMA Reports Fourth Quarter and ... 09 Feb 2006 MGI PHARMA to Present at the BIO CEO and Investor Conference Feb 7, 2006 NeoPharm Announces Completion of PRECISE Trial Enrollment as Per ... Dec 9, 2005 MGI PHARMA Announces Expiration of Tender Offer for Guilford ... Nov 29, 2005 GSW Worldwide to Lead SaforisTM Launch Campaign for MGI PHARMA ... Nov 14, 2005 MGI PHARMA Completes Acquisition of Guilford Pharmaceuticals Oct 3, 2005 MGI PHARMA Reports Third Quarter Financial Results Oct 19, 2005 Guilford Pharmaceuticals Stockholders Vote to Approve MGI PHARMA ... Sep 30, 2005 Zevalin® May Substitute for Total Body Irradiation When Combined ... Oct 6, 2005 Guilford Pharmaceuticals Stockholders Vote to Approve MGI PHARMA ... Sep 29, 2005 MGI PHARMA Completes Acquisition of Guilford Pharmaceuticals Oct 3, 2005 Zevalin® May Substitute for Total Body Irradiation When Combined ... Oct 6, 2005 Mixed Outcomes for Radiosurgery in Brain Tumors Sep 16, 2005 Radiation Dose Escalation as Treatment for Clinically Localized ... Sep 13, 2005 High-Dose Sequential Chemotherapy and Autologous Stem Cell ... Sep 13, 2005 High-Dose Sequential Chemotherapy and Autologous Stem Cell ... 08 Sep 2005 MGI PHARMA and Guilford Pharmaceuticals Announce Expiration of the ... Sep 1, 2005 FDA Sends SuperGen Warning Letter Over Nipent Handout Aug 22, 2005 New Microfluidics Device Can Deliver Targeted Anti-Cancer Drugs to ... Aug 30, 2005 Zanosar® Superior to Doxorubicin for Advanced Carcinoid Tumors Aug 2, 2005 MGI PHARMA to Acquire Guilford Pharmaceuticals Jul 21, 2005 MGI Pharma to acquire Guilford Jul 21, 2005 Temodar®/BiCNU® Prior to and Following Radiation Therapy in ... Jul 20, 2005 Two Studies Show Zevalin® Effective in Elderly Patients with ... Jun 30, 2005 | ||
| Dosage Forms | 100 mg single dose vials of lyophilized material | ||
| Drug_Category | Antineoplastic Agents; ATC:L01AD01 | ||
| Absorption | 5 to 28% bioavailability | ||
| Interactions |
Interactions for Carmustine: No information provided. | ||
| Toxicity | LD50=20 mg/kg (rat), LD50=45 mg/kg (mouse). Side effects include leukopenia, thrombocytopenia, nausea. Toxic effects include pulmonary fibrosis (20-0%) and bone marrow toxicity. | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | N-(2-chloroethyl)-1-(2-chloroethylamino)-N-nitroso-methanamide | ||
| Chemical Formula | C5H9Cl2N3O2 | ||
| Molecular Weight | 214.049 g/mol | ||
| Smiles String | C(CCl)NC(=O)N(CCCl)N=O | ||
| Melting Point | 30 °C | ||
| Water Solubility | < 0.1 g/100 mL at 18 °C | ||
| State | lyophilized pale yellow flakes | ||
| LogP/Hphobicity | 1.256 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Hepatic | ||
| Half Life | 15-30 minutes | ||
| Protein Binding [%] | 80% | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Carmustine.html http://www.rxlist.com/cgi/generic3/carmustine.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00006 | ||
| CAS Registry Number | 154-93-8 | ||
| KEGG Compound ID | C06873 | ||
| PubChem ID | SID:152253 | ||
| PharmGKB ID | PA448810 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2238985 |
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