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Carboplatin
drug data and news
Carboplatin drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Carboplatin | ||
| Brand Names/Synonyms | Cbdca; Carboplatin (USAN); cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II); Platinum(II), (1, 1-cyclobutanedicarboxylato)diammine-, cis-; Platinum, {diammine[1,1-cyclobutanedicarboxylato(2-)-O,O']-,} (SP-4-2)-; Platinum, diamine(1, 1-cyclobutanedicarboxylato(2-)-O,O')-, (SP-4-2)-; Paraplatin; Paraplatin-AQ | ||
| Indication | For the initial treatment of advanced ovarian carcinoma in established combination with other approved chemotherapeutic agents. One established combination regimen consists of PARAPLATIN and cyclophosphamide. | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Carboplatin is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Alkylating agents are cell cycle-nonspecific. Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death. | ||
| Mechanism Of Action | Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their attempts to replace the alkylated bases, preventing DNA synthesis and RNA transcription from the affected DNA, 2) DNA damage via the formation of cross-links (bonds between atoms in the DNA) which prevents DNA from being separated for synthesis or transcription, and 3) the induction of mispairing of the nucleotides leading to mutations. | ||
| Carboplatin News (When available) |
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| Dosage Forms | SOLUTION | ||
| Drug_Category | Antineoplastic Agents; ATC:L01XA02 | ||
| Absorption | Not Available | ||
| Interactions | Interactions for Carboplatin: The renal effects of nephrotoxic compounds may be potentiated by Carboplatin. | ||
| Toxicity | Toxic by ingestion. May be create toxic effect through inhalation or skin contact. May cause reproductive defects. May act as a sensitizer. ORL-RAT LD50 343 mg kg-1; SCN-RAT LD50 72 mg kg-1; IPN-MUS LD50 118 mg kg-1 | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | platinum;cyclobutane-1,1-dicarboxylicacid;azanide | ||
| Chemical Formula | C6H12N2O4Pt2 | ||
| Molecular Weight | 371.249 g/mol | ||
| Smiles String | C1CC(C1)(C(=O)O)C(=O)O.[NH2-].[NH2-].[Pt] | ||
| Melting Point | Not Available | ||
| Water Solubility | Not Available | ||
| State | Solid | ||
| LogP/Hphobicity | Not Available | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Not Available | ||
| Half Life | 1.1-2 hours | ||
| Protein Binding [%] | Very low | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Carboplatin.html http://www.rxlist.com/cgi/generic3/carboplat.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00466 | ||
| CAS Registry Number | 41575-94-4 | ||
| KEGG Compound ID | C12799 | ||
| PubChem ID | SID:794720 | ||
| PharmGKB ID | PA448803 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2126680 |
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