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Carbinoxamine
drug data and news
Carbinoxamine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Carbinoxamine | ||
| Brand Names/Synonyms | Allergefon; Carbinoxamine; Carbinoxamine Maleate; Clistin; Paracarbinoxamine; Paracarinoxamine; Rotoxamine; Twiston | ||
| Indication | For symptomatic relief of seasonal and perennial allergic rhinitis and vasomotor rhinitis | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Carbinoxamine is an antihistamine of the ethanolamine class. Ethanolamine antihistamines have significant antimuscarinic activity and produce marked sedation in most patients. In addition to the usual allergic symptoms, the drug also treats irritant cough and nausea, vomiting, and vertigo associated with motion sickness. It also is used commonly to treat drug-induced extrapyramidal symptoms as well as to treat mild cases of Parkinson's disease. Rather than preventing the release of histamine, as do cromolyn and nedocromil, carbinoxamine competes with free histamine for binding at HA-receptor sites. Carbinoxamine competitively antagonizes the effects of histamine on HA-receptors in the GI tract, uterus, large blood vessels, and bronchial muscle. Ethanolamine derivatives have greater anticholinergic activity than do other antihistamines, which probably accounts for the antidyskinetic action of carbinoxamine. | ||
| Mechanism Of Action | Carbinoxamine competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. Carbinoxamine's anticholinergic action appears to be due to a central antimuscarinic effect, which also may be responsible for its antiemetic effects, although the exact mechanism is unknown. | ||
| Carbinoxamine News (When available) |
FDA Joins Investigation of Infants’ Deaths Believed to Have Been ... Feb 26, 2006 | ||
| Dosage Forms | Oral Drops; Syrup; Tablet | ||
| Drug_Category | Antihistamines; ATC:R06AA08 | ||
| Absorption | Not Available | ||
| Interactions |
Interactions for Carbinoxamine: Antihistamines may enhance the effects of tricyclic antidepressants, barbiturates, alcohol, and other CNS depressants. MAO inhibitors prolong and intensify the anticholinergic effects of antihistamines. Sympathomimetic amines may reduce the antihypertensive effects of reserpine, veratrum alkaloids, methyldopa and mecamylamine. Effects of sympathomimetics are increased with MAO inhibitors and beta adrenergic blockers. | ||
| Toxicity | Not Available | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 2-sulfanylethanesulfonicacid | ||
| Chemical Formula | C16H19ClN2O | ||
| Molecular Weight | 290.788 g/mol | ||
| Smiles String | CN(C)CCOC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2 | ||
| Melting Point | < 25 °C | ||
| Water Solubility | Not Available | ||
| State | Liquid | ||
| LogP/Hphobicity | 2.979 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Not Available | ||
| Half Life | 10 to 20 hours | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Carbinoxamine.html http://www.rxlist.com/cgi/generic3/rondecsyr.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00765 | ||
| CAS Registry Number | 486-16-8 | ||
| KEGG Compound ID | C06871 | ||
| PubChem ID | CID:2564 | ||
| PharmGKB ID | PA448795 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | Not Available |
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