Calcitonin, salmon drug data and news

Calcitonin, salmon drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name

Calcitonin, salmon

Brand Names/Synonyms

Calcitonin 1 precursor; Miacalcin (Novartis)

Indication

For treatment of post-menopausal osteoporosis

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Description

Synthetic peptide, 32 residues long formulated as a nasal spray

Pharmacology

Calcitonin inhibits bone removal by osteoclasts (bone remodeling cells) and promotes bone formation by osteoblasts. This leads to a net increase in bone mass. Calcitonin also reduces plasma calcium levels and enhances secretion of ions in the kidney.

Mechanism Of Action

Calcitonin binds to the calcitonin receptor (found primarily in osteoclasts) which then enhances the production of vitamin D producing enzymes (25-hydroxyvitamine D-24-hydroxylase), leading to greater calcium retention and enhanced bone density. Binding of calcitonin to its receptor also activates adenylyl cyclase and the phosphatidyl-inositol-calcium pathway.

Calcitonin, salmon News
(When available)

Nastech's Facility Approved for Commercial Manufacturing of ... Feb 28, 2006
Successful completion of this PAI enables Nastech to manufacture calcitonin-salmon nasal spray for commercial use upon FDA approval of the Company's ANDA ... - PR Newswire (press release),

FDA approves Bothell facility for making osteoporosis spray Feb 28, 2006
...announced Tuesday the successful completion of the FDA's pre-approval inspection of its Bothell facility for the manufacture of a calcitonin-salmon nasal spray ... - Puget Sound Business Journal,

Nastech site OK'd for osteoporosis spray Feb 28, 2006
The company said the Food and Drug Administration accepted its filing in February 2004 seeking approval of the generic calcitonin-salmon nasal spray. ... - United Press International

Business briefs Mar 1, 2006
Possible approval of Nastech's generic calcitonin-salmon drug has been slowed by a petition filed with the FDA that seeks to delay production of generics. ... - The Herald,

Hurdles block generic drugs Feb 13, 2006
Nastech, which focuses on developing new and reformulated nasal drugs, took a different approach with calcitonin-salmon, Miacalcin's generic name. ... - Seattle Times,

Dosage Forms

Not Available

Drug_Category

Antihypocaclemic Agents; Antiosteporotic Agents

Absorption

Not Available

Interactions

Not Available

Toxicity

Not Available

Organisms Affected

Humans and other mammals

Chemical IUPAC Name

Salmon calcitonin

Chemical Formula

C145H241N43O49S2

Molecular Weight

3434.8

Smiles String

Not Available

Melting Point

Not Available

Water Solubility

Not Available

State

Transparent, slightly viscous, aqueous liquid

LogP/Hphobicity

-0.537

Isoelectric Point

8.86

Biotransformation

Not Available

Half Life

Not Available

Protein Binding [%]

Not Available

RxList Link

RXlist

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Drug Reference

http://www.rxlist.com/cgi/generic2/calcit.htm

Drug Type

Approved Drug

Accession No

BIOD00025

CAS Registry Number

12/9/9007

KEGG Compound ID

C06865

PubChem ID

9082

PharmGKB ID

PA448716

SwissProt ID

CALC1_ONCKE (P01263)

GenBank ID

Y00765

Drug ID Number [DIN]

Not Available