Butalbital drug data and news

Butalbital drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name

Butalbital

Brand Names/Synonyms

Acid; Alisobumal; Allylbarbital; Allylbarbitone; Allylbarbituric Acid; Allylisobutylbarbital; Allylisobutylbarbituric Acid; Butalbarbital; Butalbital; Butalbital-Permethylated; Isobutylallylbarbituric Acid; Isobutylallylbarturic Acid; Itobarbital; O,O-Dimethylylbutabarbital; Optalidon; Profundal; Sandoptal; Tetrallobarbital

Indication

For the relief of the symptom of complex tension (or muscle contraction) headache (esp. Fioricet)

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Description

Not Available

Pharmacology

Butalbital, a barbiturate, is used in combination with acetaminophen or aspirin and caffeine for its sedative and relaxant effects in the treatment of tension headaches, migraines, and pain. Barbiturates act as nonselective depressants of the central nervous system (CNS), capable of producing all levels of CNS mood alteration from excitation to mild sedation, hypnosis, and deep coma. In sufficiently high therapeutic doses, barbiturates induce anesthesia.

Mechanism Of Action

Butalbital binds at a distinct binding site associated with a Cl^- ionopore at the GABA_A receptor, increasing the duration of time for which the Cl^- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.

Butalbital News
(When available)

FIORICET,or it's genenic Butalbital, is a non-nar Feb 19, 2006
FIORICET ®, or it's genenic Butalbital, is a non-narcotic pain medication. Fioricet is often prescribed for tension. headaches and migraines. ... - Fly Away Simulation,

COMPLETE BREAKDOWN OF WWE WELLNESS PROGRAM Feb 27, 2006
The non-medical use of drugs belonging to this class, including, but not limited to, Amobarbital (Amytal), Butabarbital (Butisol), Butalbital (Anolor 300, Esgic ... - Pro Wrestling Insider,

Investigation leads to firing of town cop Feb 22, 2006
According to the board, a drug screen conducted last September 29 showed evidence of the substance Butalbital in Mr. Easterday’s urine, shortly after the ... - Brown County Democrat,

Big Stone Gap woman sentenced in DUI fatality Jan 31, 2006
He said blood test results of Fields revealed the presence of alcohol, marijuana, Butalbital and Diazepam in her system. Fields entered a guilty plea. ... - Kingsport Times News,

Jury to hear 1998 murder case Jan 21, 2006
Deleon's defense revolves around the fact that a fatal amount of the prescription drug butalbital -- one of three main ingredients of a drug taken to combat ... - Macomb Daily,

Avitar Enters Rapidly Expanding Oral Fluid-Based Laboratory Drug ... Nov 29, 2005
Amobarbital (Amytal(R)), Butabarbital (Butisol(R)) Pentobarbital (Nembutal(R)), Phenobarbital (Luminal(R)), Secobarbital (Seconal(R)), Butalbital (Fiorinal(R ... - PR Newswire (press release),

Ask the Clinician: Answers to Readers' Questions Nov 28, 2005
12) My Doctor prescribed Fioricet (Butalbital) for tension headaches but before taking any I noticed that it contains caffeine - could you recommend a second ... - About - News & Issues,

URL/Mutual Tracking to Achieve Another Record Year in Sales ... Sep 12, 2005
...received approval for its ANDAs for Gabapentin 100mg, 300mg and 400mg Capsules (AB- rated to Pfizer's Neurontin Capsules) and Butalbital/Acetaminophen/ and ... - PR Newswire (press release),

Blood alcohol levels questioned Aug 20, 2005
Beres also asked Torres whether traces of the prescription painkiller/sedative Butalbital found in Mason's blood could have caused her to be impaired prior to ... - Burlington Hawk Eye,

Doctor practicing at CRMC under state review Aug 17, 2005
...meperidine; 12,100 units of schedule III narcotics, hydrocodone; and 2,320 units of schedule IV drugs such as alprazolam, diazepam, phentermine and butalbital. ... - Shelby Star,

Medication Overuse Headache: When Meds Cause the Pain Aug 19, 2005
In some cases where the MOH is being caused by medications such as butalbital compounds that have been taken daily in large amounts, seizures can occur if the ... - headaches.about.com

Doctor faces sex, narcotics charges Jul 23, 2005
...meperidine; 12,100 units of Schedule III narcotics, hydrocodone; and 2,320 units of Schedule IV drugs such as alprazolam, diazepam, phentermine and butalbital. ... - Shelby Star <**results**>

Able unable to meet investors Jul 4, 2005
...the painkillers Ultram (tramadol), Vicodin and Lortab (both acetaminophen and hydrocodone), Darvocet (propoxyphene), Fioricet (butalbital, acetaminophen, and ... - in-PharmaTechnologist,

Tramadol 50mg, Imitrex (Sumatriptan), Butalbital APAP w/Caffeine ... Apr 5, 2005
Among the medications available for tension and migraine headache are Butalbital APAP w/Caffeine (generic Fioricet), Imitrex (Sumatriptan) oral tablets, 180 ... - Khalsa News Network,

Dosage Forms

TABLETS

Drug_Category

Analgesics; ATC:N05CA

Absorption

Well absorbed from the gastrointestinal tract

Interactions

-->Interactions for Butalbital:

The CNS effects of butalbital may be enhanced by monoamine oxidase (MAO) inhibitors. Butalbital, acetaminophen and caffeine may enhance the effects of: other narcotic analgesics, alcohol, general anesthetics, tranquilizers such as chlordiazepoxide, sedative-hypnotics, or other CNS depressants, causing increased CNS depression.

Drug/Laboratory Test Interactions

Acetaminophen may produce false-positive test results for urinary 5-hydroxyindoleacetic acid.

Toxicity

Symptoms attributable to acute barbiturate poisoning include drowsiness, confusion, and coma; respiratory depression; hypotension; shock.

Organisms Affected

Humans and other mammals

Chemical IUPAC Name

5-(2-methylpropyl)-5-prop-2-enyl-hexahydropyrimidine-2,4,6-trione

Chemical Formula

C11H16N2O3

Molecular Weight

224.256 g/mol

Smiles String

CC(C)CC1(C(=O)NC(=O)NC1=O)CC=C

Melting Point

138-139 °C

Water Solubility

1700 mg/L

State

Solid

LogP/Hphobicity

1.429

Isoelectric Point

Not Available

Biotransformation

Primarily hepatic. Urinary excretion products included parent drug (about 3.6% of the dose), 5-isobutyl-5-(2,3-dihydroxypropyl) barbituric acid (about 24% of the dose), 5-allyl-5(3-hydroxy-2-methyl-1-propyl) barbituric acid (about 4.8%)

Half Life

35 hours

Protein Binding [%]

45%

RxList Link

RXlist

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Drug Reference

http://www.rxlist.com/cgi/generic/esgic.htm

Drug Type

Approved Drug

Accession No

APRD00266

CAS Registry Number

77-26-9

KEGG Compound ID

Not Available

PubChem ID

SID:149431

PharmGKB ID

PA448695

SwissProt ID

Not Available

GenBank ID

Not Available

Drug ID Number [DIN]

176192