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Bromodiphenhydramine
drug data and news
Bromodiphenhydramine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
| Generic name |
Bromodiphenhydramine
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| Brand Names/Synonyms |
Ambodryl; Ambodryl Hydrochloride; Amodryl; Bromanautine; Bromazin; Bromazin Base; Bromazine; Bromazine Hydrochloride; Bromdiphenhydramine; Bromdiphenhydramine Hydrochloride; Bromdiphenylhydramine Hydrochloride; Bromo-Benadryl; Bromo-Benadryl Base; Bromo-Benzdryl; Bromodiphenhydramine; Bromodiphenhydramine Hydrochloride; Deserol; Deserol Base; H2O; Histabromamine; Neo-Benadryl; Water |
| Indication |
For managemnt of symptoms related to hay fever and other types of allergy and used to help bring up phlegm, thin secretions, and make a cough productive. |
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Description |
Not Available |
| Pharmacology |
Bromodiphenhydramine is an antihistamine of the ethanolamine class. Ethanolamine antihistamines have significant antimuscarinic activity and produce marked sedation in most patients. In addition to the usual allergic symptoms, the drug also treats irritant cough and nausea, vomiting, and vertigo associated with motion sickness. It also is used commonly to treat drug-induced extrapyramidal symptoms as well as to treat mild cases of Parkinson's disease. Rather than preventing the release of histamine, as do cromolyn and nedocromil, Bromodiphenhydramine competes with free histamine for binding at HA-receptor sites. Bromodiphenhydramine competitively antagonizes the effects of histamine on HA-receptors in the GI tract, uterus, large blood vessels, and bronchial muscle. Ethanolamine derivatives have greater anticholinergic activity than do other antihistamines, which probably accounts for the antidyskinetic action of Bromodiphenhydramine. This anticholinergic action appears to be due to a central antimuscarinic effect, which also may be responsible for its antiemetic effects, although the exact mechanism is unknown. |
| Mechanism Of Action |
Bromodiphenhydramine competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. |
Bromodiphenhydramine News
(When available) |
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| Dosage Forms |
TABLET |
| Drug_Category |
Antihistamines; ATC:D04AA32; ATC:D04AA33; ATC:R06AA02 |
| Absorption |
Well absorbed in the digestive tract. |
| Interactions |
Not Available |
| Toxicity |
Signs of overdose include wheezing; tightness in the chest; fever; itching; bad cough; blue skin color; fits; swelling of face, lips, tongue, or throat. |
| Organisms Affected |
Humans and other mammals |
| Chemical IUPAC Name |
2-[(4-bromophenyl)-phenyl-methoxy]-N,N-dimethyl-ethanamine |
| Chemical Formula |
C17H20BrNO |
| Molecular Weight |
334.251 g/mol |
| Smiles String |
CN(C)CCOC(C1=CC=CC=C1)C2=CC=C(C=C2)Br |
| Melting Point |
Not Available |
| Water Solubility |
Not Available |
| State |
Solid |
| LogP/Hphobicity |
4.549 |
| Isoelectric Point |
Not Available |
| Biotransformation |
Hepatic (cytochrome P-450 system); some renal. |
| Half Life |
1 to 4 hours |
| Protein Binding [%] |
96% |
| RxList Link |
Not Available>RXlist |
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| Drug Reference |
http://www.drugs.com/cons/Bromodiphenhydramine_and_Codeine.html |
| Drug Type |
Approved Drug |
| Accession No |
APRD00710 |
| CAS Registry Number |
1808-12-4 |
| KEGG Compound ID |
Not Available |
| PubChem ID |
SID:270958 |
| PharmGKB ID |
Not Available |
| SwissProt ID |
Not Available |
| GenBank ID |
Not Available |
| Drug ID Number [DIN] |
469122
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