Bromocriptine drug data and news

Bromocriptine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name Bromocriptine
Brand Names/Synonyms Alti-Bromocriptine; Apo-Bromocriptine; Bromergocryptine; Bromocriptin; Bromocriptina [Inn-Spanish]; Bromocriptine; Bromocriptine Mesylate; Bromocriptine Methanesulfonate; Bromocriptine [Usan:Ban:Inn]; Bromocriptinum [Inn-Latin]; Bromocryptine; Bromocryptine Mesylate; Bromoergocriptine; Bromoergocryptine; CB 154; CB-154; CCRIS 3244; Parlodel; Parlodel Snaptabs
Indication For treatment of idiopathic or postencephalitic Parkinson's disease, dysfunctions associated with hyperprolactinemia and in the treatment of acromegaly
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Description Not Available
Pharmacology Bromocriptine is an ergoline derivitave dopamine agonist that is used in the treatment of amenorrhea, female infertility, abnormal discharge of breast milk, hypogonadism, Parkinson's disease, and acromegaly. Bromocriptine produces its therapeutic effect in the treatment of Parkinson's disease, a clinical condition characterized by a progressive deficiency in dopamine synthesis in the substantia nigra, by directly stimulating the dopamine receptors in the corpus striatum.
Mechanism Of Action Bromocriptine acts by directly stimulating the dopamine receptors in the corpus striatum.
Bromocriptine News
(When available)

Q HAVE been diagnosed with cyclical mastalgia. What can I do?  Jan 30, 2006
Your GP may prescribe hormones like bromocriptine or danazol but these may have severe side effects. Q WHAT is the best way to treat my child for diarrhoea? ... - Glasgow Daily Record,

Association of COMT Val158Met Genotype With Executive Functioning ...  Jan 23, 2006
...this interpretation is supported by the results of McDowell et al., 25 who observed an effect of a dopamine receptor agonist, bromocriptine, on prefrontal ... - Journal of Neuropsychiatry (subscription)

Apathy and Its Treatment in Alzheimer's Disease and Other ...  Dec 5, 2005
Muller U, von Cramon DY (1994), The therapeutic potential of bromocriptine in neuropsychological rehabilitation of patients with acquired brain damage. ... - Psychiatric Times,

Long isoform of prolactin receptor predominates in rat ...  Nov 18, 2005
Hormonal regulation of PrlR expression was evaluated by comparing intact rats with gonadectomized, pituitary-grafted or bromocriptine-treated animals. ... - Journal of Endocrinology

Prevalence and Treatment of Depression in Parkinson’s Disease  Sep 24, 2005
There is a lack of well-designed controlled studies in this area, but preliminary research suggests that bromocriptine and pramipexole may have mood-altering ... - Journal of Neuropsychiatry (subscription)

Pregnancy changes the body forever  Oct 2, 2005
Wrapping the breasts tightly, or binding, can help relieve engorgement. In the past, some medications, such as bromocriptine, were prescribed for this. ... - Orlando Sentinel,

Understanding breast pain  Aug 22, 2005
...changes. The drug bromocriptine works for some women, though side effects include facial hair growth and fertility problems. Losing ... - News 14 Carolina,

Multiple System Atrophy  Jul 31, 2005
Other medications that may be used are bromocriptine (Parlodel), trihexyphenidyl (Artane), benztropine mesylate (Cogentin), and amantadine (Symmetrel). ... - rarediseases.about.com

Parkinson's drugs tied to compulsive behaviors  Jul 11, 2005
...of compulsive gambling in Parkinson patients, all of whom were taking dopamine agonists (pramipexole, pergolide, ropinirole, bromocriptine and cabergoline). ... - Reuters.uk <**results**>

Breast Pain Isn’t Just a Menstrual Complaint  Jun 28, 2005
Three medications — danazol, tamoxifen, and bromocriptine — have been shown to relieve breast pain, but these drugs can cause serious side effects. - Newswise (press release)

Breast Pain Isn't Just A Menstrual Complaint, Says Harvard Women's ...  Jun 22, 2005
Three medications -- danazol, tamoxifen, and bromocriptine -- have been shown to relieve breast pain, but these drugs can cause serious side effects. - U.S. Newswire (press release),

Age-Defying Equines  Jun 1, 2005
Drug therapy includes antibiotics to manage recurrent infections or pergolide, bromocriptine, and cyproheptadine to treat clinical signs of ECD. ... - TheHorse.com,

Yohimbe and Erectile Dysfunction  Apr 7, 2005
...the pro-sexual effect of yohimbine doesn't wear off in the same way the pro-sexual effect of neurophysiological agents such as bromocriptine (Parlodel) does. ... - Khalsa News Network,

Still producing 'milk' two years after miscarriage?  Mar 20, 2005
If the milk secretion becomes excessive and fertility is desired, then either bromocriptine (Parlodel) or Dopergin tablets are usually effective in decreasing ... - Jamaica Observer,

Dosage Forms CAPSULE
Drug_Category Antiparkinson Agents; Antidyskinetics; Unclassified Therapeutic Agents (92:00.00); ATC:G02CB01; ATC:N04BC01
Absorption Not Available
Interactions Interactions for Bromocriptine:

The risk of using bromocriptine mesylate in combination with other drugs has not been systematically evaluated, but alcohol may potentiate the side effects of bromocriptine mesylate. Bromocriptine mesylate may interact with dopamine antagonists, butyrophenones, and certain other agents. Compounds in these categories result in a decreased efficacy of bromocriptine mesylate: phenothiazines, haloperidol, metoclopramide, pimozide. Concomitant use of bromocriptine mesylate with other ergot alkaloids is not recommended.

Toxicity Not Available
Organisms Affected Humans and other mammals
Chemical IUPAC Name Not Available
Chemical Formula C32H40BrN5O5
Molecular Weight 654.595 g/mol
Smiles String CC(C)CC1C(=O)N2CCCC2C3(N1C(=O)C(O3)(C(C)C)NC(=O)C4CN(C5CC6=C(NC7=CC=CC(=C67)C5=C4)Br)C)O
Melting Point Not Available
Water Solubility Not Available
State Solid
LogP/Hphobicity Not Available
Isoelectric Point Not Available
Biotransformation Not Available
Half Life 4-15 hours
Protein Binding [%] 90-96%
RxList Link RXlist
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Drug Reference http://www.drugs.com/cons/Bromocriptine.html
http://www.rxlist.com/cgi/generic3/bromocriptine.htm
Drug Type Approved Drug
Accession No APRD00622
CAS Registry Number 25614-03-3
KEGG Compound ID C06856
PubChem ID SID:174998
PharmGKB ID PA448671
SwissProt ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] 2236949

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