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Bivalirudin
drug data and news
Bivalirudin drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Bivalirudin | ||
| Brand Names/Synonyms | Angiomax; Angiomax (Medicines Co or MDCO) | ||
| Indication | For treatment of heparin-induced thrombocytopenia | ||
| Sponsored links | Description | Synthetic 20 residue peptide (thrombin inhibitor) | |
| Pharmacology | Angiomax directly inhibits thrombin by specifically binding both to the catalytic site and to the anion-binding exosite of circulating and clot-bound thrombin. Thrombin is a serine proteinase that plays a central role in the thrombotic process, acting to cleave fibrinogen into fibrin monomers and to activate Factor XIII to Factor XIIIa, allowing fibrin to develop a covalently cross-linked framework which stabilizes the thrombus; thrombin also activates Factors V and VIII, promoting further thrombin generation, and activates platelets, stimulating aggregation and granule release | ||
| Mechanism Of Action | Inhibits the action of thrombin by binding both to its catalytic site and to its anion-binding exosite. | ||
| Bivalirudin News (When available) |
The Medicines Company Announces Glenn Sblendorio to Be New Chief ... 06 Mar 2006 The Medicines Company Reports Fourth Quarter and Full Year 2005 ... Feb 15, 2006 Chairman of Cleveland Clinic Department of Cardiovascular Medicine ... Feb 9, 2006 Panacos Appoints Dr. John D. Richards Vice President ... Feb 13, 2006 The Medicines Company to Announce Fourth Quarter and Full Year ... Feb 8, 2006 News For Your Web Site 09 Feb 2006 Angiomax(R) (Bivalirudin) Recommended for Use in Percutaneous ... Nov 15, 2005 Angiomax(R) (Bivalirudin) Recommended for Use in Percutaneous ... Nov 15, 2005 FDA Approvals: Angiomax, Depakote ER, Hylenex Dec 8, 2005 The Medicines Company Completes Enrollment of 13,800-Patient ... Dec 7, 2005 Enrolment of 13,800 patients completed in global trial of Angiox® ... Dec 7, 2005 TODAY ON PHARMALIVE.COM Dec 1, 2005 The Addition of INTEGRILIN(R) (Eptifibatide) Injection Achieved ... Nov 14, 2005 Angiomax OK'd for HIT/HITTS Dec 1, 2005 The Medicines Company Lowers 2005 Guidance; Reports Preliminary ... Oct 5, 2005 New anticoagulant faces the challenge of bleeding in PCI Sep 11, 2005 The Medicines Company to Present at UBS Global Life Sciences ... Sep 26, 2005 The Medicines Company Appoints Melvin Spigelman, MD to Board of ... Sep 29, 2005 Clopidogrel for Percutaneous Coronary Revascularization Time for ... Sep 13, 2005 Direct Thrombin Inhibitors: Not Ready for Prime Time? 08 Sep 2005 The Medicines Company to Present at Bear Stearns 18th Annual ... Sep 7, 2005 Clopidogrel for Percutaneous Coronary Revascularization Sep 4, 2005 The Medicines Company [MDCO] Chairman & CEO to Ring The NASDAQ ... Aug 12, 2005 The Medicines Company to Present at Banc of America Conference Jul 22, 2005 Increase in Diagnosed Events and Revascularization Procedures will ... Aug 1, 2005 The Medicines Company to Announce Second Quarter 2005 Financial ... Jul 13, 2005 The Medicines Company Reports Second Quarter and First Half 2005 ... Jul 20, 2005 FDA Approves Expansion of the Medicines Company's Angiomax-R ... Jun 15, 2005 Assessment of hemostatic activation during cardiopulmonary bypass ... Jun 14, 2005 FDA Approvals: Angiomax, Lyrica, Zmax Jun 16, 2005 To Cath or Not to Cath That Is No Longer the Question Jun 14, 2005 | ||
| Dosage Forms | Not Available | ||
| Drug_Category | Anticoagulants; Antithrombotic Agents | ||
| Absorption | Not Available | ||
| Interactions | Not Available | ||
| Toxicity | Not Available | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | FPRPGGGGNGDFEEIPEEYL | ||
| Chemical Formula | C98H138N24O33 | ||
| Molecular Weight | 2180.3 | ||
| Smiles String | Not Available | ||
| Melting Point | Not Available | ||
| Water Solubility | Not Available | ||
| State | Transparent, slightly viscous, aqueous liquid | ||
| LogP/Hphobicity | -0.985 | ||
| Isoelectric Point | 3.91 | ||
| Biotransformation | Not Available | ||
| Half Life | 25 min (in normal conditions) | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference | http://www.rxlist.com/cgi/generic/angiomax.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | BIOD00076 | ||
| CAS Registry Number | 128270-60-0 | ||
| KEGG Compound ID | Not Available | ||
| PubChem ID | SID:214065 | ||
| PharmGKB ID | PA10032 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | Not Available |
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