Bevacizumab drug data and news

Bevacizumab drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name Bevacizumab
Brand Names/Synonyms Avastin; antiVEGF; Avastin (Genentech Inc)
Indication For treatment of metastatic colorectal cancer
Sponsored links
Description A recombinant humanized monoclonal IgG1 antibody that binds to and inhibits the biologic activity of human vascular endothelial growth factor (VEGF). Bevacizumab contains human framework regions and the complementarity-determining regions of a murine antibody that binds to VEGF. Bevacizumab is produced in a Chinese Hamster Ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin and has a molecular weight of approximately 149 kilodaltons.
Pharmacology Bevacizumab prevents or reduces the formation of blood vessels (angiogenesis) thereby preventing or reducing metatstatic disease progressing. Bevacizumab binds VEGF and prevents vascular endothelial growth and endothelial cell proliferation.
Mechanism Of Action Bevacizumab binds VEGF and prevents the interaction of VEGF to its receptors (Flt-1 and KDR) on the surface of endothelial cells. This prevents blood vessel growth.
Bevacizumab News
(When available)

State to Improve HIV Data Monitoring  Mar 3, 2006
...recently asked the Medicines Control Council to speed up registration of tenofovir, and urged government to provide it instead of stavudine (d4t), saying it ... - AllAfrica.com,

Advances in First-Line and "Switch" Antiretroviral Strategies for ...  Feb 2, 2006
In this study, 602 HIV-infected, treatment-naive individuals were randomized to receive lamivudine/efavirenz together with either tenofovir or stavudine. ... - Medscape (subscription)

Fringe wins for pharma, but cos seek stronger dose  Feb 28, 2006
Budget. Some of these drugs are cisplatin, stavudine, danazol and didanosine. However, the industry sees these as minor concessions. ... - Economic Times,

CROI: Lipodystrophy stable in children on HIV treatment and does ...  Feb 23, 2006
In addition, the same group of doctors found that switching young patients from an HIV treatment combination containing d4T (stavudine, Zerit) led to an ... - Aidsmap,

Restoration of CD4 T-cells limited in children starting HIV ...  Mar 2, 2006
The majority (74%) of the children took two NRTIs alongside their protease inhibitor, the commonest being d4T (stavudine, Zerit) and 3TC (lamivudine, Epivir). ... - Aidsmap,

CROI: Side effects, especially neuropathy and rash, common but ...  Feb 8, 2006
...patients, they are no more likely to be severe than in patients in industrialised countries, and appear chiefly related to the d4T (stavudine) component of ... - Aidsmap,

CROI: Low rates of resistance seen in Staccato trial of CD4-guided ...  Feb 26, 2006
NRTIs). These were either d4T (stavudine, Zerit) and ddI (didanosine, VidexEC) or tenofovir (Viread) and 3TC (lamivudine, Epivir). ... - Aidsmap,

HIV/Aids: FG Receives Nine Locally Manufactured ARV Drugs  Feb 24, 2006
The nine drugs include: Xilec Tablet (Zidovudine 300mg), Lavudine Tablet (Lamivudine 150mg), Melxican Cap, (Stavudine 40mg), Arved (Zidevudine/Lamivudine ... - AllAfrica.com,

Researchers note sharp drop in Zim HIV prevalence  Feb 7, 2006
...despite limited funds, has established a national anti-retroviral roll-out programme consisting of a single-dose formulation of stavudine, lamivudine and ... - Mail & Guardian Online,

70% still on first regimen after 3 years in Khayelitsha, but ...  Feb 7, 2006
...efavirenz. Later in the study period, the standard first-line regimen was changed to d4T (stavudine) plus 3TC plus nevirapine. In ... - Aidsmap,

Insulin resistance common in HIV-positive children  Feb 6, 2006
...including exercise, healthy diets, and, possibly, avoidance of anti-HIV drugs linked to the syndrome, such as protease inhibitors and d4T (stavudine, Zerit). ... - Aidsmap,

Simplified treatment regimens show promise in HIV-infected ...  Feb 6, 2006
...switching, all of the children were taking 3TC (lamivudine, Epivir) and abacavir (Ziagen), along with either AZT (zidovudine, Retrovir) or d4T (stavudine, Zerit ... - Aidsmap,

Rapid scale-up of HIV treatment in Zambia  Feb 7, 2006
The standard first-line drug regimen consisted of AZT (zidovudine) or d4T (stavudine), plus 3TC (lamivudine), plus nevirapine or efavirenz. ... - Aidsmap,

CROI: Capsaicin patch helps relieve neuropathy  Feb 10, 2006
...is caused both by HIV and by certain HIV medications, such as ddI (didanosine, Videx / VidexEC), ddC (zalcitabine, Hivid) and d4T (stavudine, Zerit), nicknamed ... - Aidsmap,

Zambia: ARV Rollout - Quality Not Quantity?  Feb 14, 2006
...then Zambia's health minister, announced in parliament that supplies of Triomune-30, a fixed-dose combination of Nevirapine, Lamivudine and Stavudine, had run ... - AllAfrica.com,

CROI: Disappointment for glitazones, metformin and testosterone ...  Feb 10, 2006
...positive individuals on antiretrovirals are still being investigated, there is increasing agreement that the thymidine analogues, d4T (stavudine, Zerit) and ... - Aidsmap,

New 48 Week Clinical Trial Data Reported Comparing REYATAZ(R) ...  Feb 9, 2006
...group (the approved dose for this patient population), each combined with lamivudine (3TC) and the investigational compound stavudine extended release as a once ... - Finanzen.net,

CROI: Atazanavir and atazanavir/ritonavir safe and effective in ...  Feb 13, 2006
...once daily. All patients also received once-daily 3TC (lamivudine, Epivir) and extended-release d4T (stavudine, Zerit PRC). The ... - Aidsmap,

CROI: AZT, 3TC and FTC achieve good concentrations in the female ...  Feb 17, 2006
The women were treated with antiretroviral regimens that included 3TC, AZT, abacavir (Ziagen), ddI (didanosine, Videx), d4T (stavudine, Zerit), efavirenz ... - Aidsmap,

Multi-component drug delivery system: An emerging trend  Feb 8, 2006
Ziagen), lamivudine, 3TC (Epivir), tenofovir (Viread), abacavir/lamivudine /zidovudine (Trizivir), lamivudine/zidovudine (Combivir), stavudine, d4T (Zerit ... - Express Pharma Pulse,

New 48 Week Clinical Trial Data Reported Comparing REYATAZ(R) ...  09 Feb 2006
...group (the approved dose for this patient population), each combined with lamivudine (3TC) and the investigational compound stavudine extended release as a once ... - Yahoo! News (press release)

CROI: Side effects, especially neuropathy and rash, common but ...  Feb 8, 2006
...patients, they are no more likely to be severe than in patients in industrialised countries, and appear chiefly related to the d4T (stavudine) component of ... - Aidsmap,

Multi-component drug delivery system: An emerging trend  Feb 8, 2006
Ziagen), lamivudine, 3TC (Epivir), tenofovir (Viread), abacavir/lamivudine /zidovudine (Trizivir), lamivudine/zidovudine (Combivir), stavudine, d4T (Zerit ... - Express Pharma Pulse,

Researchers note sharp drop in Zim HIV prevalence  Feb 8, 2006
...despite limited funds, has established a national anti-retroviral roll-out programme consisting of a single-dose formulation of stavudine, lamivudine and ... - Zimbabwe Independent,

FDA Tentatively Approves a Generic AIDS Drug in Association with ...  Jan 18, 2006
The FDA recently announced the tentative approval of Stavudine (stav' yoo deen) for Oral Solution, 1 mg/mL to be manufactured by Aurobindo Pharma LTD. ... - Pharmaceutical Processing,

Archivir, Nigeria’s indigenous ARV debuts  Jan 31, 2006
Explaining that the drug is a fixed dose combination consisting of Lamivudine, Stavudine and Nevirapine, he stresses that it is produced locally. ... - African News Dimension,

Drug price reduction makes Aids manageable  Jan 25, 2006
Since then, it has secured voluntary licenses from Bristol-Myers Squibb (for stavudine and didanosine), Boehringer Ingleheim (for nevirapine) and Merck Sharp & ... - iAfrica.com,

Policy prevents Naco from ordering drug  Jan 25, 2006
Named as Emtri Suspension, the three-drug cocktail -- Lamivudine, Stavudine and Nevirapine -- is already being exported to African countries like Kenya and ... - TMCnet

Study Sets New Gold Standard For Initial Antiretroviral Treatment ...  Jan 25, 2006
Association, which showed that tenofovir DF was equally effective but had fewer side effects than another antiretroviral drug called stavudine (d4T, Zerit). ... - Science Daily (press release)

Policy prevents Naco from ordering drug  Jan 24, 2006
Named as Emtri Suspension, the three-drug cocktail — Lamivudine, Stavudine and Nevirapine — is already being exported to African countries like Kenya and ... - Times of India,

ICAAC: Nevirapine’s manufacturer examines rates of liver ...  Jan 9, 2006
...and nevirapine. All of the patients took a background combination of 3TC (lamivudine, Epivir) and d4T (stavudine, Zerit). Although ... - Aidsmap,

Almost a third of Indian patients make changes to first-line ...  Jan 19, 2006
These cases deserve closer study. d4T (stavudine, Zerit) toxicity caused 27 (15%) of the 183 patients to change treatments. However ... - Aidsmap,

Fat loss associated with Combivir but not Truvada  Jan 23, 2006
Drugs from the nucleoside reverse transcriptase inhibitor class, particularly d4T (stavudine, Zerit) have been associated with fat loss. ... - Aidsmap,

ICAAC: Switch from AZT or d4T to tenofovir may improve blood fat ...  Jan 13, 2006
Patients switching from anti-HIV drug regimens containing AZT (zidovudine, Retrovir) or d4T (stavudine, Zerit) may show better improvements in blood fat levels ... - Aidsmap,

Aurobindo products in WHO list  Jan 17, 2006
Nevirapine oral suspension 50 mg / 5 ml and Stavudine for oral solution 1 mg / ml in the Pre-qualification list. |Read more Finance news.|. ... - Sify,

Dosage Forms Not Available
Drug_Category Antiangiogenesis Agents; Antineoplastic Agents
Absorption Not Available
Interactions Not Available
Toxicity Not Available
Organisms Affected Humans and other mammals
Chemical IUPAC Name Humanized anti-VEGF antibody
Chemical Formula Not Available
Molecular Weight Not Available
Smiles String Not Available
Melting Point 61 oC (FAB fragment), 71 oC (whole mAb) - Vermeer, A.W.P. & Norde, W., Biophys. J. 78:394-404 (2000).
Water Solubility Not Available
State Transparent, slightly viscous, aqueous liquid
LogP/Hphobicity Not Available
Isoelectric Point Not Available
Biotransformation Most likely removed by opsonization via the reticuloendothelial system when bound to endothelial cells, or by human antimurine antibody production
Half Life Not Available
Protein Binding [%] Not Available
RxList Link RXlist
Sponsored links
Drug Reference http://www.drugs.com/cons/Bevacizumab.html
http://www.rxlist.com/cgi/generic3/avastin.htm
Drug Type Approved Drug
Accession No BIOD00087
CAS Registry Number 216974-75-3
KEGG Compound ID Not Available
PubChem ID Not Available
PharmGKB ID PA130232992
SwissProt ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] Not Available

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