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Betazole
drug data and news
Betazole drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
| Generic name |
Betazole
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| Brand Names/Synonyms |
Ametazole; Betazol [Inn-Spanish]; Betazole; Betazolo [Dcit]; Betazolum [Inn-Latin]; Histalog |
| Indication |
For use clinically to test gastric secretory function. |
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Description |
Not Available |
| Pharmacology |
Betazole is a histamine H2 agonist used in a test for measuring maximal production of gastric acidity or anacidity. This measurement can be used to diagnose diseases such as Zollinger-Ellison syndrome, whereby the volume of gastric and basal secretions is measured following betazole administration (greater than 60% of the maximal acid secretion following betazole stimulation). In another test, gastritis can be diagnosed given late absence of gastric acid which is unresponsive to betazole stimulation. Betazole can be used as a gastric secretory stimulant instead of histamine with the advantage of not provoking side effects and thus not requiring the use of antihistaminic compounds. |
| Mechanism Of Action |
Betazole is a histamine analogue. It produces the same effects as histamine, binding the H2 receptor which is a mediator of gastric acid secretion. This agonist action thereby results in an increase in the volume of gastric acid produced. |
Betazole News
(When available) |
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| Dosage Forms |
INJECTION |
| Drug_Category |
Gastrointestinal Agents; Histamine Agonists; ATC:V04CG02 |
| Absorption |
Rapid and complete. |
| Interactions |
Not Available |
| Toxicity |
Not Available |
| Organisms Affected |
Humans and other mammals |
| Chemical IUPAC Name |
2-(2H-pyrazol-3-yl)ethanamine |
| Chemical Formula |
C5H9N3 |
| Molecular Weight |
111.145 g/mol |
| Smiles String |
C1=C(NN=C1)CCN |
| Melting Point |
< 25 °C |
| Water Solubility |
Not Available |
| State |
Liquid |
| LogP/Hphobicity |
0.069 |
| Isoelectric Point |
Not Available |
| Biotransformation |
Not Available |
| Half Life |
Not Available |
| Protein Binding [%] |
> 99% |
| RxList Link |
Not Available>RXlist |
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| Drug Reference |
Not Available |
| Drug Type |
Approved Drug |
| Accession No |
APRD00714 |
| CAS Registry Number |
105-20-4 |
| KEGG Compound ID |
Not Available |
| PubChem ID |
SID:287072 |
| PharmGKB ID |
Not Available |
| SwissProt ID |
Not Available |
| GenBank ID |
Not Available |
| Drug ID Number [DIN] |
Not Available
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