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Betamethasone
drug data and news
Betamethasone drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Betamethasone | ||
| Brand Names/Synonyms | Alphatrex; Bebate; Becort; Bedifos; Beta-Methasone; Beta-Methasone Alcohol; Beta-Val; Betacorlan; Betacortril; Betaderm; Betadexamethasone; Betafluorene; Betamamallet; Betametasona [Inn-Spanish]; Betametasone [Dcit]; Betamethasone; Betamethasone Alcohol; Betamethasone Base; Betamethasone Cream; Betamethasone Dipropionate; Betamethasone Sodium Phosphate; Betamethasone Valearate; Betamethasone Valerate; Betamethasone [Usan:Ban:Inn:Jan]; Betamethasonum [Inn-Latin]; Betamethasonvalerat Mikron.; Betamethazone; Betapredol; Betasolon; Betatrex; Betnelan; Betsolan; Celestene; Celestone; Celestone Syrup and Tablets; Cidoten; Dermabet; Desacort-Beta; Diproderm; Diprolene; Diprolene Af; Diprosone; Flubenisolone; HSDB 3015; Hormezon; Lotrisone; Luxiq; Luxiqo; Maxivate; Methazon; Rinderon; Rinderon A; Sch 4831; Uticort; Valisone; Valnac; Visubeta | ||
| Indication | For relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Betamethasone and its derivatives, betamethasone sodium phosphate and betamethasone acetate, are synthetic glucocorticoids. Used for its antiinflammatory or immunosuppressive properties, betamethasone is combined with a mineralocorticoid to manage adrenal insufficiency and is used in the form of betamethasone benzoate, betamethasone dipropionate, or betamethasone valerate for the treatment of inflammation due to corticosteroid-responsive dermatoses. Betamethasone and clotrimazole are used together to treat cutaneous tinea infections. | ||
| Mechanism Of Action | Betamethasone is a glucocorticoid Receptor Agonist. The antiinflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. The immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding. Betamethasone binds to plasma transcortin, and it becomes active when it is not bound to transcortin. | ||
| Betamethasone News (When available) |
Topical therapies show promise for Psoriasis 06 Mar 2006 Betamethasone Affects Cerebral Expressions of NF- B and Cytokines ... Feb 24, 2006 Harper’s Findings Mar 5, 2006 TODAY ON PHARMALIVE.COM Mar 3, 2006 President leaves PediaMed after sales force sold Feb 27, 2006 Kav's Undoubtedly last but not least Feb 5, 2006 Riders finally to receive medals Feb 5, 2006 America awarded Olympic gold Feb 6, 2006 Prices of 112 formulations reduced Feb 1, 2006 NPPA Fixes/Revises Prices Of Bulk Drugs And Formulations Feb 1, 2006 NPPA reduces prices of 112 formulations Feb 1, 2006 Taro Receives Tentative Approval for Augmented Betamethasone ... Jan 26, 2006 FDA Approves Taclonex (Calcipotriene/Betamethasone Dipropionate) ... Jan 10, 2006 Connetics Names Freddie Park Vice President, Intellectual Property ... Feb 6, 2006 America awarded Olympic gold Feb 6, 2006 Taro tentatively OK'd for Diprolene Jan 26, 2006 Kav's Undoubtedly last but not least Feb 5, 2006 Riders finally to receive medals Feb 5, 2006 NPPA Fixes/Revises Prices Of Bulk Drugs And Formulations Feb 1, 2006 NPPA reduces prices of 112 formulations Feb 1, 2006 Prices of 112 formulations reduced Feb 1, 2006 Hayes keeps nine options for Blue Diamond Jan 31, 2006 Connetics Acquires PediaMed Sales Organization; Enters Pediatric ... Jan 10, 2006 Burbs: Atlas Air CEO to step down Jan 31, 2006 FDA Approves Taclonex(R) - Once Daily Therapy for Treatment of ... Jan 10, 2006 Pregnancy drugs can affect grandkids Nov 30, 2005 Concern over pregnancy drug Nov 30, 2005 Warner Chilcott Reports Results for the Quarter and Nine Months ... Nov 11, 2005 Connetics Names Srabasti Mukherjee Associate Director, Business ... Nov 10, 2005 Investigational Psoriasis Therapy May Represent an Effective New ... Oct 25, 2005 Investigational Psoriasis Therapy May Represent an Effective New ... Oct 26, 2005 Neonatal Morbidity and Growth in Very Low Birth-Weight Infants ... Oct 26, 2005 Drugs and Competition Oct 23, 2005 Connetics Founder Eugene A. Bauer Steps Down as Director after 11 ... Oct 17, 2005 Rockingham Memorial Hospital Oct 16, 2005 Enters into co-promotion agreement with Bristol-Myers Squibb for ... Oct 3, 2005 Connetics Launches AcneMedicine.com; A New Online Resource to Help ... 11 Oct 2005 Two-Drug Topical Treatment Effective in Early Mycosis Fungoides Sep 28, 2005 FIXATION/REVISION OF PRICES OF BULK DRUGS UNDER DPCO, 1995. Sep 19, 2005 NPPA revises 16 bulk drug prices Sep 19, 2005 Enters into co-promotion agreement with Bristol-Myers Squibb for ... Oct 3, 2005 NPPA cuts prices of asthma, anti-inflammatory drugs Sep 19, 2005 NPPA revises 16 bulk drug prices Sep 20, 2005 Foamix Commences Phase II Study of TerbiFoam(TM) 2% Foam for the ... Sep 12, 2005 Foamix to commence Phase II clinical trial of athlete’s foot ... Sep 12, 2005 Foamix Commences Phase II Study of TerbiFoam 2% Foam for the ... Sep 12, 2005 Alliance aims at foam-based treatment for scabies Sep 22, 2005 NPPA FIXES/REVISES THE PRICES OF 308 FORMULATION PACKS Sep 19, 2005 Foamix begins phase II athlete's foot trial Sep 13, 2005 | ||
| Dosage Forms | Syrup; Tablet | ||
| Drug_Category | Corticosteroid; Glucocorticoids; Anti-inflammatory, steroidal; Immunosuppressant; ATC:A07EA04; ATC:C05AA05; ATC:D07AC01; ATC:D07XC01; ATC:H02AB01; ATC:R01AD06; ATC:R03BA04; ATC:S01BA06; ATC:S01CB04; ATC:S02BA07; ATC:S03BA03 | ||
| Absorption | Minimal if applied topically | ||
| Interactions |
Interactions for Betamethasone: APRD00513_IN,txt | ||
| Toxicity | burning, itching, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, skin atrophy, striae, miliaria. | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one | ||
| Chemical Formula | C22H29FO5 | ||
| Molecular Weight | 392.461 g/mol | ||
| Smiles String | CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CO)O)C)O)F)C | ||
| Melting Point | 231-234°C | ||
| Water Solubility | Insoluable | ||
| State | white to practically white, odorless, crystalline powder | ||
| LogP/Hphobicity | 1.772 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | hepatic | ||
| Half Life | 5.6 hours | ||
| Protein Binding [%] | 64% | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Betamethasone.html http://www.rxlist.com/cgi/generic2/betamet.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00513 | ||
| CAS Registry Number | 378-44-9 | ||
| KEGG Compound ID | C06848 | ||
| PubChem ID | SID:152998 | ||
| PharmGKB ID | PA448605 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 716618 |
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