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Benztropine
drug data and news
Benztropine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Benztropine | ||
| Brand Names/Synonyms | Akitan; Apo-Benztropine; Benzatropina [Inn-Spanish]; Benzatropine; Benzatropinum [Inn-Latin]; Benztropine; Benztropine Mesylate; Benztropinum; Cobrentin; Cogentin; Cogentine; Cogentinol; HSDB 3014; NK 02; NK-02; Pms Benztropine; Tropine Benzohydryl Ether | ||
| Indication | For use as an adjunct in the therapy of all forms of parkinsonism and also for use in the control of extrapyramidal disorders due to neuroleptic drugs. | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Benztropine is an anticholinergic used in the symptomatic treatment of all etiologic groups of parkinsonism and drug induced extrapyramidal reactions (except tardive dyskinesia). Benztropine possesses both anticholinergic and antihistaminic effects, although only the former has been established as therapeutically significant in the management of parkinsonism. Benztropine's anticholinergic activity is about equal to that of atropine. | ||
| Mechanism Of Action | Benztropine is a selective M1 muscarinic acetylcholine receptor antagonist. It is able to discriminate between the M1 (cortical or neuronal) and the peripheral muscarinic subtypes (cardiac and glandular). Benztropine partially blocks cholinergic activity in the CNS, which is responsible for the symptoms of Parkinson's disease. It is also thought to increase the availability of dopamine, a brain chemical that is critical in the initiation and smooth control of voluntary muscle movement. | ||
| Benztropine News (When available) |
Risk of Serious Harm and/or Death With Potential IV/SC ... Feb 15, 2006 | ||
| Dosage Forms | TABLET | ||
| Drug_Category | Antiparkinson Agents; Muscarinic Antagonists; Antidyskinetics; ATC:N04AC01 | ||
| Absorption | Not Available | ||
| Interactions |
Interactions for Benztropine: Antipsychotic drugs such as phenothiazines or haloperidol; tricyclic antidepressants. | ||
| Toxicity | Signs of overdose include confusion, nervousness, listlessness, hallucinations, dizziness; muscle weakness; ataxia, dry mouth, mydriasis, blurred vision, palpitations, tachycardia, elevated blood pressure, nausea, vomiting, dysuria, numbness of fingers, headache, delirium, coma, shock, convulsions, respiratory arrest, anhidrosis, hyperthermia, glaucoma, and constipation. | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 3-benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octane | ||
| Chemical Formula | C21H25NO | ||
| Molecular Weight | 307.429 g/mol | ||
| Smiles String | CN1C2CCC1CC(C2)OC(C3=CC=CC=C3)C4=CC=CC=C4 | ||
| Melting Point | Not Available | ||
| Water Solubility | Very soluble | ||
| State | Solid | ||
| LogP/Hphobicity | 4.987 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Not Available | ||
| Half Life | Not Available | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Benztropine.html http://www.rxlist.com/cgi/generic2/benztrop.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00748 | ||
| CAS Registry Number | 86-13-5 | ||
| KEGG Compound ID | C06846 | ||
| PubChem ID | SID:331152 | ||
| PharmGKB ID | PA448591 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 706531 |
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