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Benzthiazide
drug data and news
Benzthiazide drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Benzthiazide | ||
| Brand Names/Synonyms | Aquatag; Benzothiazide; Benzthazide; Benzthiazide; Dihydrex; Diucen; Edemex; Exna; Exosalt; Fovane; Freeuril; Hydrine; Lemazide; Naclex; P 1393; Pfizer 1393; Proaqua; Urese | ||
| Indication | For the treatment of high blood pressure and management of edema | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Benzthiazide is used to treat hypertension and edema. Like other thiazides, benzthiazide promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue. | ||
| Mechanism Of Action | As a diuretic, benzthiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like benzthiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. The antihypertensive mechanism of benzthiazide is less well understood although it may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle. | ||
| Benzthiazide News (When available) |
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| Dosage Forms | TABLET | ||
| Drug_Category | Antihypertensive Agents; Diuretics; Stimulants; ATC:C03AA | ||
| Absorption | Absorbed in the digestive tract. | ||
| Interactions |
Interactions for Benzthiazide: Benzthiazide may interact with alcohol, blood thinners, decongestant drugs (allergy, cold, and sinus medicines), diabetic drugs, lithium, norepinephrine, NSAIDs like Aleve or Ibuprofen, and high blood pressure medications. | ||
| Toxicity | Symptoms of overdose include nausea, vomiting, fatigue, urinary problems and drowsiness. | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 3-(benzylsulfanylmethyl)-9-chloro-5,5-dioxo-5λ6-thia-2,4-diazabicyclo[4.4.0]deca-3,6,8,10-tetraene-8-sulfonamide | ||
| Chemical Formula | C15H14ClN3O4S3 | ||
| Molecular Weight | 431.94 g/mol | ||
| Smiles String | C1=CC=C(C=C1)CSCC2=NS(=O)(=O)C3=CC(=C(C=C3N2)Cl)S(=O)(=O)N | ||
| Melting Point | 231.5 °C | ||
| Water Solubility | 8.91 mg/L | ||
| State | Solid | ||
| LogP/Hphobicity | 2.918 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Not Available | ||
| Half Life | Not Available | ||
| Protein Binding [%] | 30% | ||
| RxList Link | Not Available>RXlist | ||
| Sponsored links | |||
| Drug Reference | Not Available | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00728 | ||
| CAS Registry Number | 91-33-8 | ||
| KEGG Compound ID | C07759 | ||
| PubChem ID | SID:9961 | ||
| PharmGKB ID | PA448590 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | Not Available |
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