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Benzphetamine
drug data and news
Benzphetamine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Benzphetamine | ||
| Brand Names/Synonyms | Benzfetamine; Benzphetamine; Benzylamphetamine; Didrex | ||
| Indication | For the management of exogenous obesity as a short term adjunct (a few weeks) in a regimen of weight reduction based on caloric restriction | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Benzphetamine, a phenylalkylamin, is related to amphetamine both chemically and pharmacologically. It is an anorectic agent indicated in the management of exogenous obesity as a short term adjunct (a few weeks) in a regimen of weight reduction based on caloric restriction. Benzphetamine is a sympathomimetic amine with pharmacologic activity similar to the prototype drugs of this class used in obesity, the amphetamines. Actions include central nervous system stimulation and elevation of blood pressure. Tachyphylaxis and tolerance have been demonstrated with all drugs of this class in which these phenomena have been looked for. | ||
| Mechanism Of Action | Although the mechanism of action of the sympathomimetic appetite suppressants in the treatment of obesity is not fully known, these medications have pharmacological effects similar to those of amphetamines. Amphetamine and related sympathomimetic medications (such as benzphetamine) are thought to stimulate the release of norepinephrine and/or dopamine from storage sites in nerve terminals in the lateral hypothalamic feeding center, thereby producing a decrease in appetite. This release is mediated by the binding of benzphetamine to centrally located adrenergic receptors. | ||
| Benzphetamine News (When available) |
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| Dosage Forms | TABLET (SCORED) | ||
| Drug_Category | Adrenergic Agents; Dopamine Agents; Central Nervous System Agents; ATC:A08AA | ||
| Absorption | Readily absorbed from the gastro-intestinal tract and buccal mucosa. It Is resistant to metabolism by monoamine oxidase. | ||
| Interactions |
Interactions for Benzphetamine: Hypertensive crises have resulted when sympathomimetic amines have been used concomitantly within14 days following use of monoamine oxidase inhibitors. DIDREX should not be used concomitantly with other CNS stimulants. Amphetamines may decrease the hypotensive effect of antihypertensives. Amphetamines may enhance the effects of tricyclic antidepressants. Urinary alkalinizing agents increase blood levels and decrease excretion of amphetamines. Urinary acidifying agents decrease blood levels and increase excretion of amphetamines. | ||
| Toxicity | Oral, rat LD50: 160 mg/kg. Acute overdosage may result in restlessness, tremor, tachypnea, confusion, assaultiveness, and panic states. | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | N-benzyl-N-methyl-1-phenyl-propan-2-amine | ||
| Chemical Formula | C17H21N | ||
| Molecular Weight | 239.355 g/mol | ||
| Smiles String | CC(CC1=CC=CC=C1)N(C)CC2=CC=CC=C2 | ||
| Melting Point | 152-153 °C | ||
| Water Solubility | Readily soluble | ||
| State | Solid (white crystalline powder) | ||
| LogP/Hphobicity | 4.374 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Hepatic. Benzphetamine's metabolites include amphetamine and methamphetamine. | ||
| Half Life | 16 to 31 hours | ||
| Protein Binding [%] | 75-99% | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Benzphetamine.html http://www.rxlist.com/cgi/generic/benzphet.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00759 | ||
| CAS Registry Number | 156-08-1 | ||
| KEGG Compound ID | C07538 | ||
| PubChem ID | SID:152260 | ||
| PharmGKB ID | PA448586 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | Not Available |
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