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Benzonatate
drug data and news
Benzonatate drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Benzonatate | ||
| Brand Names/Synonyms | Benzonatate; Benzonatate [Usan:Ban:Inn]; Benzonatato [Inn-Spanish]; Benzonatatum [Inn-Latin]; Benzononantin; Benzononatine; Exangit; KM65; Tesalon; Tessalin; Tessalon; Tessalon Perles; Tessalon-Ciba; Ventussin; Ventussin-Loz | ||
| Indication | For the symptomatic relief of cough | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Benzonatate, a non-narcotic antitussive agent chemically related to tetracaine and other ester-type local anesthetics, is used to suppress cough associated with both acute and chronic respiratory conditions. | ||
| Mechanism Of Action | Benzonatate acts peripherally, anesthetizing the stretch receptors of vagal afferent fibers in the alveoli of the lungs, bronchi, and pleura. When applied locally, Benzonatate binds within the intracellular portion of voltage-gated sodium channels, decreasing the rate of membrane depolarization and increasing the threshold for electrical excitability. | ||
| Benzonatate News (When available) |
COUGHING: Causes & cures Mar 5, 2006 Been coughing? That's not necessarily a bad thing Feb 28, 2006 | ||
| Dosage Forms | soft gelatin capsule containing 100mg benzonatate | ||
| Drug_Category | Antitussives; ATC:R05DB01 | ||
| Absorption | Not Available | ||
| Interactions |
Interactions for Benzonatate: No information provided. | ||
| Toxicity | restlessness, tremors, seizures and unconsciousness. | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 2-[2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl4-butylaminobenzoate | ||
| Chemical Formula | C30H53NO11 | ||
| Molecular Weight | 603.742 g/mol | ||
| Smiles String | CCCCNC1=CC=C(C=C1)C(=O)OCCOCCOCCOCCOCCOCCOCCOCCOCCOC | ||
| Melting Point | Not Available | ||
| Water Solubility | soluble in most organic solvents except aliphatic hydrocarbons | ||
| State | colorless to faintly yellow oil | ||
| LogP/Hphobicity | 1.873 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Not Available | ||
| Half Life | 3- 8 hours | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Benzonatate.html http://www.rxlist.com/cgi/generic/benzon.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00629 | ||
| CAS Registry Number | 104-31-4 | ||
| KEGG Compound ID | C06844 | ||
| PubChem ID | SID:9062 | ||
| PharmGKB ID | Not Available | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | Not Available |
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