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Benzocaine
drug data and news
Benzocaine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Benzocaine | ||
| Brand Names/Synonyms | Aethoform; Amben Ethyl Ester; Americaine; Anaesthan-Syngala; Anaesthesin; Anaesthin; Anestezin; Anesthesin; Anesthesine; Anesthone; Baby Anbesol; Benzocaine; Dermoplast; Ethoform; Ethyl Aminobenzoate; Ethyl P-Aminobenzoate; Ethyl P-Aminophenylcarboxylate; Ethylester Kyseliny P-Aminobenzoove; Hurricaine; Identhesin; Keloform; Norcain; Norcaine; Ora-Jel; Orthesin; P-Aminobenzoic Acid, Ethyl Ester; P-Carbethoxyaniline; P-Ethoxycarboxylic Aniline; Parathesin; Parathesine; Solarcaine; Solu H; Topcaine | ||
| Indication | For general use as a lubricant and topical anesthetic on esophagus, larynx, mouth, nasal cavity, rectum, respiratory tract or trachea, urinary tract, vagina. It is also used to suppress gag reflex. | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Benzocaine is a local anesthetic commonly used as a topical pain reliever. It is the active ingredient in many over-the-counter analgesic ointments. It is also indicated for general use as a lubricant and topical anesthetic on intratracheal catheters and pharyngeal and nasal airways to obtund the pharyngeal and tracheal reflexes; on nasogastric and endoscopic tubes; urinary catheters; laryngoscopes; proctoscopes; sigmoidoscopes and vaginal specula. | ||
| Mechanism Of Action | Benzocaine binds to sodium channel and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions. Depolarization of the neuronal membrane is inhibited thereby blocking the initiation and conduction of nerve impulses. | ||
| Benzocaine News (When available) |
FDA Issues Public Health Advisory Regarding Benzocaine Sprays Feb 15, 2006 FDA Issues Public Health Advisory on Benzocaine Sprays Feb 14, 2006 FDA Issues Public Health Advisory About Benzocaine Sprays Feb 13, 2006 FDA Warns About Risks of Throat-Numbing Spray Feb 14, 2006 USDA listens to horse industry Feb 11, 2006 | ||
| Dosage Forms | dental paste; film-forming gel; liquid; ointment | ||
| Drug_Category | Anesthetics; Antipruritics; Local Anesthetics; ATC:C05AD03; ATC:D04AB04; ATC:N01BA05; ATC:R02AD01 | ||
| Absorption | Not Available | ||
| Interactions |
Interactions for Benzocaine: No information is available. | ||
| Toxicity | LD50=3040 mg/kg (rat, oral) | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | ethyl4-aminobenzoate | ||
| Chemical Formula | C9H11NO2 | ||
| Molecular Weight | 165.189 g/mol | ||
| Smiles String | CCOC(=O)C1=CC=C(C=C1)N | ||
| Melting Point | 92 °C | ||
| Water Solubility | 1310 mg/L | ||
| State | Solid | ||
| LogP/Hphobicity | 1.536 | ||
| Isoelectric Point | 2.51 | ||
| Biotransformation | Not Available | ||
| Half Life | Not Available | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Benzocaine.html http://www.rxlist.com/cgi/generic3/americaine.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00539 | ||
| CAS Registry Number | 94-09-7 | ||
| KEGG Compound ID | C07527 | ||
| PubChem ID | SID:9730 | ||
| PharmGKB ID | PA448576 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2223805 |
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