| Generic name |
Basiliximab
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| Brand Names/Synonyms |
Ig gamma-1 chain C region; chimeric mouse-human antiCD25; Simulect (Novartis Pharmaceuticals) |
| Indication |
For prophylactic treatment of kidney transplant rejection |
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Description |
A recombinant chimeric (murine/human) monoclonal antibody (IgG1k) that functions as an immunosuppressive agent, specifically binding to and blocking the interleukin-2 receptor a-chain (IL-2R alpha, also known as CD25 antigen) on the surface of activated T-lymphocytes. It is a 144 kDa glycoprotein obtained from fermentation of an established mouse myeloma cell line genetically engineered to express plasmids containing the human heavy and light chain constant region genes and mouse heavy and light chain variable region genes encoding the RFT5 antibody that binds selectively to the IL-2R alpha. |
| Pharmacology |
Simulect functions as an IL-2 receptor antagonist. Specifically it inhibits IL-2-mediated activation of lymphocytes, a critical pathway in the cellular immune response involved in allograft rejection. |
| Mechanism Of Action |
Simulect binds with high-affinity to the Tac subunit of the high-affinity IL-2 receptor complex and inhibits IL-2 binding. The IL-2 receptor (Tac) subunit is expressed on activated but not resting lymphocytes. |
Basiliximab News
(When available) |
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| Dosage Forms |
POWDER FOR SOLUTION |
| Drug_Category |
Immunosupressants; Immunomodulatory Agents; unclassified therapeutic agents (92:00.00) |
| Absorption |
Not Available |
| Interactions |
Not Available |
| Toxicity |
Not Available |
| Organisms Affected |
Humans and other mammals |
| Chemical IUPAC Name |
Chimeric murine/human anti-CD25 antibody |
| Chemical Formula |
C6378H9844N1698O1997S48 >1MIM:L Anti-CD25 antibody light CHIMERIC chain 1 >1MIM:H Anti-CD25 antibody heavy CHIMERIC chain 2 >1MIM:L Anti-CD25 antibody light CHIMERIC chain 2 |
| Molecular Weight |
143801.3 |
| Smiles String |
Not Available |
| Melting Point |
61 oC (FAB fragment), 71 oC (whole mAb) - Vermeer, A.W.P. & Norde, W., Biophys. J. 78:394-404 (2000). |
| Water Solubility |
Not Available |
| State |
Transparent, slightly viscous, aqueous liquid |
| LogP/Hphobicity |
-0.473 |
