Azithromycin drug data and news

Azithromycin drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name Azithromycin
Brand Names/Synonyms Aritromicina [Spanish]; Azenil; Azithramycine; Azithromycin; Azithromycin Dihydrate; Azithromycin Sterile; Azithromycin [Usan:Ban:Inn]; Azithromycine; Azithromycine [French]; Azithromycinum [Latin]; Azitromax; Aziwok; Aztrin; CCRIS 1961; DRG-0104; HSDB 7205; Hemomycin; Misultina; Mixoterin; Setron; Sumamed; Tobil; Tromix; Zeto; Zifin; Zithrax; Zithromax; Zitrim; Zitromax; Zitrotek
Indication For the treatment of patients with mild to moderate infections caused by susceptible strains of the designated microorganisms in the specific conditions: H. influenzae, M.catarrhalis, S.pneumoniae, C.pneumoniae, .M.pneumoniae, S.pyogenes, S.aureus, S.agal
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Description Not Available
Pharmacology Azithromycin, a semisynthetic antibiotic belonging to the macrolide subgroup of azalides, is used to treat STDs due to chlamydia and gonorrhea, community-acquired pneumonia, pelvic inflammatory disease, pediatric otitis media and pharyngitis, and Mycobacterium avium complex (MAC) in patients with advanced HIV disease. Similar in structure to erythromycin. azithromycin reaches higher intracellular concentrations than erythromycin, increasing its efficacy and duration of action.
Mechanism Of Action Azithromycin binds to the 50S subunit of the 70S bacterial ribosomes, and therefore inhibits RNA-dependent protein synthesis in bacterial cells.
Azithromycin News
(When available)

Alpharma to Present SG Cowen & Co. Health Care Conference  Mar 3, 2006
Alpharma has a growing branded franchise in the chronic pain market with its morphine-based extended release KADIAN(R) product. ... - PR Newswire (press release),

Kahuku girls pin down title  Mar 5, 2006
...year.". Punahou's Kara Takasaki also repeated as a state champion at 140 pounds, pinning Lahainaluna's Kadian Shaw at 5:32. Staff ... - Honolulu Advertiser,

Pair of aces  Mar 5, 2006
Jasmine Dollopac of Maui High at 114 pounds, Manglaylay of Lahainaluna at 120, Piikea Kalalau of Baldwin at 130 and Lahainaluna’s Kadian Shaw at 140. ... - Maui News,

BKU criticises wheat import  Feb 6, 2006
Stating this here Professor Manjit Singh Kadian, acting president of BKU and said due to the wrong policies of the government the prices of wheat and flour had ... - Webindia123,

Farmers' union opposes decision to import wheat  Feb 6, 2006
Bharti Kisan Union acting president Manjit Singh Kadian said it would take at least two months for the wheat shipment to arrive and by the third week of ... - NewKerala.com,

WTF: Gophers Total Best-Ever Score, Finish Third at Big Ten's  Feb 27, 2006
...place result. The Gophers’ foursome of Katie Grundman, Kadian Douglas, Mollie Hupp and Dorniden finished in 3:44.67. Douglas ran ... - Gophersports.com,

Six MIL wrestlers draw top seeds at state tourney  Feb 28, 2006
No. 2 at 114); Baldwin’s Natasha Chang (No. 2 at 125); Lahainaluna’s Kadian Shaw (No. 2 at 140); Lanai’s Janna Amby (No. 2 ... - Maui News,

Training for new MLAs in Haryana  Feb 2, 2006
...them make their significant contribution in debate and discussion on important issues,'' Haryana Vidhan Sabha speaker Raghubir Singh Kadian said, talking to ... - Webindia123,

Tavares, Bandits defeat Swarm  Feb 19, 2006
Kadian Douglas (60 meters, 7.59 seconds), Liz Roehrig (60 hurdles, 8.90), Ayla Mitchell (600 meters, 1:37.83) and Harper McConnell (3,000 meters, 10:10.33) won ... - Pioneer Press,

Farmers not to allow unloading of imported wheat: BKU  Feb 22, 2006
We would not allow imported wheat to be unloaded in the country and hold protests at the port," BKU (Punjab) Secretary General Manjit Singh Kadian said while ... - NewKerala.com,

WTF: Gophers Lead After Day One of Big Ten's  Feb 26, 2006
The Gophers advanced runners to tomorrow’s finals in five running events. Junior Kadian Douglas qualified for the finals in both short sprints. ... - Gophersports.com,

Women will rest runners at Big Ten Indoor meet this weekend in ...  Feb 24, 2006
The Gophers’ distance medley relay team of Dorniden, Brown, Cheever and Kadian Douglas, which shattered Minnesota’s school record by nearly 25 seconds ... - Minnesota Daily,

Despite resting athletes, women take eight titles  Feb 19, 2006
Sprinter Kadian Douglas said she’ll be looking forward to next weekend as well. She won the 60-meter dash Saturday with a time of 7.59 seconds. ... - Minnesota Daily,

No team scores  Feb 11, 2006
Ole Miss 7.52q 3 5 Devon Williams Illinois Sta 7.55q 2 6 Halimat Ismaila Texas - El P 7.57q 2 7 Jenna Harris Ohio State 7.59q 2 7 Kadian Douglas Minnesota 7.59 ... - Gophersports.com,

No team scores  Feb 18, 2006
Catherine 9.16 Round 1, Heat 5 1 Kadian Douglas, Jr, Minnesota 7.69q 2 Christine Trvdik, So, Minnesota 8.07q 3 Kristen Haak, Fr, Minnesota-Duluth 8.31 4 Jennae ... - Gophersports.com,

Gramin Rozgar Guarantee Yojana launched in Haryana  Feb 2, 2006
Haryana Assembly speaker Dr Raghubir Singh Kadian launched the scheme at village Bhawdeen in Sirsa district, by giving the forms to eleven poor men to get ... - Outlook (subscription),

Rural job scheme launched in 2 Haryana districts  Feb 2, 2006
...given to the women in giving employment as 33 per cent reservation had been provided for them, Haryana Vidhan Sabha Speaker Raghubir Singh Kadian said, while ... - Webindia123,

WTF: Gophers Win Eight Parents' Day Open Titles  Feb 19, 2006
Kadian Douglas won the 60-meter dash in 7.59 seconds and Katie Grundman was runner-up in 7.74 seconds. Ayla Mitchell won the 600 meters in 1:37.83. ... - Gophersports.com,

Maine State Police blotter  Feb 14, 2006
Eicher was arrested and charged with unlawful possession of schedule W drugs (Methadose, Kadian and heroin) and possession of hypodermic apparatuses. ... - VillageSoup Belfast,

WTF: Gophers Run Best-Ever Mile Relay; Dorniden Sets 400M School ...  Feb 11, 2006
The Gopher foursome of Katie Grundman, Dorniden, Kadian Douglas and Mollie Hupp set the school record at 3 minutes, 40.77 seconds, eclipsing the old mark of 3 ... - Gophersports.com,

WTF: Gophers’ DMR Squad Obliterates School Record  Feb 4, 2006
February 3, 2006 - The Golden Gopher women’s distance medley relay team of Jaime Cheever, Kadian Douglas, Heather Dorniden and Emily Brown clocked an NCAA ... - Gophersports.com,

WTF: Dorniden Smashes 800-Meter School Record, Brown Sets 3K Mark  Feb 4, 2006
Dorniden and Brown combined with Jaime Cheever and Kadian Douglas to form the Gophers’ DMR squad that obliterated the school’s distance medley relay record ... - Gophersports.com,

Gophers Record Best-Ever Mile Relay; Dorniden Sets 400M School ...  Feb 11, 2006
...set a year ago. The Gopher foursome of Mollie Hupp, Katie Grundman, Kadian Douglas and Dorniden placed fifth. Three of Minnesota ... - U of M Gophersports,

Russell not enrolled for spring semester  Feb 6, 2006
The team of Dorniden, Brown, Jamie Cheever and Kadian Douglas recorded a time of 11:10.40, which is an NCAA provisional qualifying time. ... - Minnesota Daily,

Home meet to be used as rest weekend for women’s squad  Feb 16, 2006
Neither will Heather Dorniden, who set or helped set four school records in the past two meets. Sprinter Kadian Douglas will perform at the meet. ... - Minnesota Daily,

AHRC takes note of state`s HR violations  Feb 8, 2006
It also demanded removal of Col KS Kadian, CO 24 AR and Maj Atul Yadav of the AR unit from their posts charging them of directly involving in the series of ... - KanglaOnline,

Kadian elected Haryana Assembly speaker  Jan 13, 2006
An agriculture scientist by training, Mr Kadian (61) had served as a state minister in the Lok Dal government headed by Ch Devi Lal during 1987-90. ... - Webindia123,

Kadian elected Haryana Assembly speaker  Jan 13, 2006
Mr Kadian's name was proposed by Parliamentry Affairs Minister Randeep Singh Surjewala and was endorsed by INLD leader Sushil Kumar Indora. ... - Webindia123,

Kadian elected Haryana speaker  Jan 13, 2006
CHANDIGARH: Congress MLA Raghbir Singh Kadian was on Friday elected Speaker of Haryana Assembly filling the vacancy caused due to the resignation of ... - Daily News & Analysis,

BKU criticises wheat import  Feb 6, 2006
Stating this here Professor Manjit Singh Kadian, acting president of BKU and said due to the wrong policies of the government the prices of wheat and flour had ... - Webindia123,

Farmers' union opposes decision to import wheat  Feb 6, 2006
Bharti Kisan Union acting president Manjit Singh Kadian said it would take at least two months for the wheat shipment to arrive and by the third week of ... - NewKerala.com,

Training for new MLAs in Haryana  Feb 2, 2006
...them make their significant contribution in debate and discussion on important issues,'' Haryana Vidhan Sabha speaker Raghubir Singh Kadian said, talking to ... - Webindia123,

AHRC takes note of state`s HR violations  Feb 8, 2006
It also demanded removal of Col KS Kadian, CO 24 AR and Maj Atul Yadav of the AR unit from their posts charging them of directly involving in the series of ... - KanglaOnline,

Gramin Rozgar Guarantee Yojana launched in Haryana  Feb 2, 2006
Haryana Assembly speaker Dr Raghubir Singh Kadian launched the scheme at village Bhawdeen in Sirsa district, by giving the forms to eleven poor men to get ... - Outlook (subscription),

Rural job scheme launched in 2 Haryana districts  Feb 2, 2006
...given to the women in giving employment as 33 per cent reservation had been provided for them, Haryana Vidhan Sabha Speaker Raghubir Singh Kadian said, while ... - Webindia123,

Russell not enrolled for spring semester  Feb 6, 2006
The team of Dorniden, Brown, Jamie Cheever and Kadian Douglas recorded a time of 11:10.40, which is an NCAA provisional qualifying time. ... - Minnesota Daily,

WTF: Gophers’ DMR Squad Obliterates School Record  Feb 4, 2006
February 3, 2006 - The Golden Gopher women’s distance medley relay team of Jaime Cheever, Kadian Douglas, Heather Dorniden and Emily Brown clocked an NCAA ... - Gophersports.com,

WTF: Dorniden Smashes 800-Meter School Record, Brown Sets 3K Mark  Feb 4, 2006
Dorniden and Brown combined with Jaime Cheever and Kadian Douglas to form the Gophers’ DMR squad that obliterated the school’s distance medley relay record ... - Gophersports.com,

No team scores  Jan 21, 2006
21, 2006 60 Meter Dash Round 1, Heat 1 1 Kadian Douglas, Jr, Minnesota 7.63Q 2 Heather Zander, Unattached 7.81q 3 Ashley Granger, So, Iowa 7.94q 4 Jernise ... - U of M Gophersports,

Alpharma to Present at the Merrill Lynch Global Pharmaceutical ...  Feb 2, 2006
Alpharma has a growing branded franchise in the chronic pain market with its morphine-based extended release KADIAN(R) product. ... - PR Newswire (press release),

Moreh women returns after agitating for three days.  Jan 25, 2006
...persuaded at midnight. DIG Range II Christopher Doungel, Moreh ADC Th Chothe, Brigadier of 24 AR KS Kadian also took part. MCM president ... - Asian Tribune,

Moreh still simmers, MoU rejected  Jan 23, 2006
...evening and was attended by the DIG Range II Christopher Doungel, Moreh ADC Th Chothe, Brigadier of 26 Sector Assam Rifles RA Lewis and CO of 24 AR KS Kadian. ... - E-Pao.net,

Hearing on plea for Pataudi's bail cancellation on Jan 16  Jan 11, 2006
The petition, filed by Rohtak-based social activist Naresh Kadian ofthe People For Animals(PFA), Haryana, claimed that the Jhajjar judicial magistrate had no ... - NewKerala.com,

Seniors get 'Plan D' blues - Confusion dogs debut of Medicare ...  Jan 9, 2006
She paid $95 for 30 pills of Kadian, a pain medication, after the new Medicare Prescription Drug Benefit Plan known as Part D went into effect Jan. ... - Daily Hampshire Gazette (subscription),

$4.75 million settlement in Flankers shooting case  Jan 10, 2006
...intent. They are Woman Constable Bibzie Foster and constables Metro McFarlane, Kevin Williams, Kadian Smith and Donald Thomas. The ... - Jamaica Gleaner,

WTF: Gophers Claim 11 Individual Titles at Minnesota Open  Jan 14, 2006
Track titles were also claimed by Kadian Douglas, who won the 200-meter dash (25.18), Heather Dorniden who finished first in the 600-meter dash (1:31.99) and ... - U of M Gophersports,

Cops involved in Flankers killings stand trial  Jan 20, 2006
Those to stand trial are Woman Constable Bibzie Foster, Special Constable Metro McFarlane and Constables Kevin Williams, Kadian Smith and Donald Thomas. ... - RJR,

WTF: Dorniden’s 600-Meter Title Highlights Running Performances  Jan 21, 2006
...over eight seconds. Kadian Douglas won the 60-meter dash title, breaking the tape in a winning time of 7.58 seconds. Douglas also ... - Gophersports.com,

Moreh women continue stir despite signing of MoU  Jan 24, 2006
...the CO, 24 Assam Rifles, Col. KS Kadian this afternoon at the Moreh police station. After detailed discussions on the prevailing ... - KanglaOnline,

Haryana has no intention to form human rights commission  Jan 18, 2006
...the resumed hearing on the PILs preferred on the subject by the Peoples Union For Civil Liberties (PUCL), a Rohtak-based social activist Naresh Kadian and a ... - Webindia123,

No team scores  Jan 14, 2006
Kristen Haak, Fr, Minnesota-Duluth 8.26 8 Sarah Lynch, So, Northern Iowa 8.26 9 Katie Flemming, Fr, Minn State Moorhead 8.31 200 Meter Dash 1 Kadian Douglas, Jr ... - U of M Gophersports,

Dosage Forms Oral suspension; CAPSULE; TABLET; POWDER FOR SOLUTION
Drug_Category Anti-bacterial Agents; Other Macrolides; ATC:J01FA10
Absorption 37% (Oral administration)
Interactions -->Interactions for Azithromycin:

Co-administration of nelfinavir at steady-state with a single dose of azithromycin (2 ´600 mg tablets) results in increased azithromycin serum concentrations. Although a dose adjustment of azithromycin is not recommended when administered in combination with nelfinavir, close monitoring for known side effects of azithromycin, such as liver enzyme abnormalities and hearing impairment, is warranted.

Azithromycin did not affect the prothrombin time response to a single dose of warfarin. However, prudent medical practice dictates careful monitoring of prothrombin time in all patients treated with azithromycin and warfarin concomitantly. Concurrent use of macrolides and warfarin in clinical practice has been associated with increased anticoagulant effects.

Drug interaction studies were performed with azithromycin and other drugs likely to be co-administered. When used in therapeutic doses, azithromycin had a modest effect on the pharmacokinetics of atorvastatin, carbamazepine, cetirizine, didanosine, efavirenz, fluconazole, indinavir, midazolam, rifabutin, sildenafil, theophylline (intravenous and oral), triazolam, trimethoprim/sulfamethoxazole or zidovudine. Co-administration with efavirenz or fluconazole had a modest effect on the pharmacokinetics of azithromycin. No dosage adjustment of either drug is recommended when azithromycin is co administered with any of the above agents. Interactions with the drugs listed below have not been reported in clinical trials with azithromycin; however, no specific drug interaction studies have been performed to evaluate potential drug-drug interaction. Nonetheless, they have been observed with macrolide products. Until further data are developed regarding drug interactions when azithromycin and these drugs are used concomitantly, careful monitoring of patients is advised:

Digoxinñelevated digoxin concentrations.

Ergotamine or dihydroergotamineñacute ergot toxicity characterized by severe peripheral vasospasm and dysesthesia.

Cyclosporine, hexobarbital and phenytoin concentrations.

Laboratory Test Interactions

There are no reported laboratory test interactions.

Repeat Treatment

Studies evaluating the use of repeated courses of Zmax have not been conducted.

Toxicity Potentially serious side effects of angioedema and cholestatic jaundice were reported
Organisms Affected Enteric bacteria and other eubacteria
Chemical IUPAC Name 11-(4-dimethylamino-3-hydroxy-6-methyl-oxan-2-yl)oxy-2-ethyl-3,4,10-trihydroxy-13-(5-hydroxy-4-methoxy-4,6-dimethyl-oxan-2-yl)oxy-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-one
Chemical Formula C38H72N2O12
Molecular Weight 748.985 g/mol
Smiles String CCC1C(C(C(N(CC(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)N(C)C)O)(C)O)C)C)C)O)(C)O
Melting Point 113 - 115°C
Water Solubility slight
State Crystals
LogP/Hphobicity 2.461
Isoelectric Point 8.74
Biotransformation hepatic
Half Life 68 hours
Protein Binding [%] the serum protein binding to it is variable in the concentration range approximating human exposure, decreasing from 51% at 0.02 mcg/ml to 7% at 2 mcg/ml
RxList Link RXlist
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Drug Reference http://www.drugs.com/cons/Azithromycin.html
http://www.rxlist.com/cgi/generic/azith.htm
Drug Type Approved Drug
Accession No APRD00397
CAS Registry Number 83905-01-5
KEGG Compound ID C06838
PubChem ID SID:9056
PharmGKB ID PA448519
SwissProt ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] 2255340

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