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Atenolol
drug data and news
Atenolol drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Atenolol | ||
| Brand Names/Synonyms | Aircrit; Alinor; Altol; Anselol; Antipressan; Apo-Atenolol; Atcardil; Atecard; Atehexal; Atenblock; Atendol; Atenet; Ateni; Atenil; Atenol; Atenol 1a Pharma; Atenol Acis; Atenol Al; Atenol Atid; Atenol Cophar; Atenol Ct; Atenol Fecofar; Atenol Gador; Atenol Genericon; Atenol Gnr; Atenol Heumann; Atenol Msd; Atenol Nm Pharma; Atenol Nordic; Atenol Pb; Atenol Quesada; Atenol Stada; Atenol Tika; Atenol Trom; Atenol von Ct; Atenol-Mepha; Atenol-Ratiopharm; Atenol-Wolff; Atenolin; Atenolol; Atenomel; Atereal; Aterol; Betablok; Betacard; Betasyn; Betatop Ge; Blocotenol; Blokium; CCRIS 4196; Cardaxen; Cardiopress; Corotenol; Cuxanorm; Duraatenolol; Duratenol; Evitocor; Farnormin; Felo-Bits; HSDB 6526; Hipres; Hypoten; Ibinolo; Internolol; Jenatenol; Juvental; Lo-Ten; Loten; Lotenal; Myocord; Normalol; Normiten; Noten; Oraday; Ormidol; Panapres; Plenacor; Premorine; Prenolol; Prenormine; Prinorm; Scheinpharm Atenol; Seles Beta; Selobloc; Serten; Servitenol; Stermin; Tenidon; Teno-Basan; Tenobloc; Tenoblock; Tenolol; Tenoprin; Tenoretic; Tenormin; Tenormine; Tensimin; Tredol; Unibloc; Uniloc; Vascoten; Vericordin; Wesipin; Xaten | ||
| Indication | For the management of hypertention and long-term management of patients with angina pectoris | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Atenolol, a competitive beta(1)-selective adrenergic antagonist, has the lowest lipid solubility of this drug class. Although it is similar to metoprolol, atenolol differs from pindolol and propranolol in that it does not have intrinsic sympathomimetic properties or membrane-stabilizing activity. Atenolol is used alone or with chlorthalidone in the management of hypertension and edema. | ||
| Mechanism Of Action | Like metoprolol, atenolol competes with sympathomimetic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart and vascular smooth muscle, inhibiting sympathetic stimulation. This results in a reduction in resting heart rate, cardiac output, systolic and diastolic blood pressure, and reflex orthostatic hypotension. Higher doses of atenolol also competitively block beta(2)-adrenergic responses in the bronchial and vascular smooth muscles. | ||
| Atenolol News (When available) |
Glaxo Loses US Court Bid to Block Generic Flonase (Update1) 06 Mar 2006 Roxane Laboratories, Inc. Announces the Launch of Fluticasone ... Feb 23, 2006 GlaxoSmithKline blocks sales of competitor's generic Flonase Feb 27, 2006 First Generic Version of Flonase Approved Feb 23, 2006 FDA Approves First Generic Version of Flonase Feb 22, 2006 GlaxoSmithKline blocks sales of generic competitor to its Flonase ... Feb 24, 2006 FDA Approves Generic Version Of Flonase Nasal Spray Feb 23, 2006 First Generic of Glaxo's Flonase is Approved Feb 24, 2006 First Generic Version of Flonase Approved Feb 23, 2006 GSK blocks generic Flonase in USA, for now Feb 27, 2006 FDA OKs Generic Version of Flonase Feb 22, 2006 FDA Approves First Generic Form of Flonase Feb 23, 2006 Par Pharmaceutical Reports Sales and Earnings for 2005 Feb 28, 2006 FDA approves generic version of Flonase Feb 22, 2006 FDA approves generic competitor to Glaxo's Flonase Feb 22, 2006 Par Pharmaceutical Halts Shipment of Generic Flonase(R) Feb 24, 2006 Generic Flonase blocked in court Feb 25, 2006 FDA approves generic version of popular allergy drug Flonase Feb 28, 2006 Doctors required to reveal links with drug firms Feb 12, 2006 Par Pharmaceutical Begins Shipment of Generic Flonase(R) Feb 23, 2006 Steroid puff best for kids with persistent asthma Feb 10, 2006 Boehringer Ingelheim Announces 48-week Results from Aptivus(R) ... Feb 9, 2006 UPDATE 1-US FDA approves generic version of GSK nasal spray Feb 22, 2006 Par Pharma halts generic Flonase shipments after GSK wins ... Feb 24, 2006 National Briefing Feb 24, 2006 FDA approves generic version of Flonase nasal spray Feb 22, 2006 Another generic rises against Glaxo Feb 23, 2006 FDA approves generic Flonase spray Feb 24, 2006 Judge orders halt to sales of generic Flonase Feb 24, 2006 GlaxoSmithKline blocks sales of generic competitor to Flonase Feb 26, 2006 GlaxoSmithKline "in-line," estimates revised Feb 24, 2006 Lundergan group buys Continental Inn Feb 24, 2006 GlaxoSmithKline: Pliva Deal to Boost R&D Feb 15, 2006 Generic nasal spray sales blocked Feb 25, 2006 Asthma treatment led to girl’s death Feb 12, 2006 GSK's Flonase facing generic rival in USA Feb 23, 2006 Cash relief in store for allergy sufferers Feb 24, 2006 SNP urges registers of interest for all health authorities Feb 13, 2006 Sepracor: arformoterol offers relief Feb 16, 2006 SCHWARZ PHARMA /Full Year Report 2005 Feb 17, 2006 2005 - the year of recovery for GSK Feb 9, 2006 Boehringer Ingelheim Announces 48-week Results from Aptivus(R) ... 09 Feb 2006 2005 - the year of recovery for GSK 09 Feb 2006 Inhaled Corticosteroids Most Effective for Persistent Asthma in ... Jan 10, 2006 ICS Most Effective For Persistent Asthma In Children Jan 11, 2006 Breathe Easier! Jan 22, 2006 Inhaled Steroid Controls Asthma Better Than Oral Agent Jan 12, 2006 Study targets better asthma treatments Jan 17, 2006 SkyePharma will not merge with Innovata Jan 12, 2006 Study Compares Kids' Asthma Drugs Jan 19, 2006 AstraZeneca's Symbicort gives asthma patients the power to get ... Jan 13, 2006 Teen should wait on pill - and on sex Jan 24, 2006 | ||
| Dosage Forms | Tablets as 25, 50 and 100 mg tablets for oral adminstration, I.V. Injection | ||
| Drug_Category | Sympatholytics; Antihypertensive Agents; Antiarrhythmic Agents; Adrenergic Agents; ATC:C07AB03; ATC:C07AB11 | ||
| Absorption | oral dose if rapid and consisten but incomplete. Approximately 50% of an oral dose is absorbed from the gastrointestinal tract, the remainder being excreted unchanged in the feces. | ||
| Interactions |
Interactions for Atenolol: Catecholamine-depleting drugs (eg, reserpine) may have an additive effect when given with beta-blocking agents. Patients treated with TENORMIN plus a catecholamine depletor should therefore be closely observed for evidence of hypotension and/or marked bradycardia which may produce vertigo, syncope, or postural hypotension. Calcium channel blockers may also have an additive effect when given with TENORMIN . Beta blockers may exacerbate the rebound hypertension which can follow the withdrawal of clonidine. If the two drugs are coadministered, the beta blocker should be withdrawn several days before the gradual withdrawal of clonidine. If replacing clonidine by beta-blocker therapy, the introduction of beta blockers should be delayed for several days after clonidine administration has stopped. Concomitant use of prostaglandin synthase inhibiting drugs, eg, indomethacin, may decrease the hypotensive effects of beta blockers. Information on concurrent usage of atenolol and aspirin is limited. Data from several studies, ie, TIMI-II, ISIS-2, currently do not suggest any clinical interaction between aspirin and beta blockers in the acute myocardial infarction setting. While taking beta blockers, patients with a history of anaphylactic reaction to a variety of allergens may have a more severe reaction on repeated challenge, either accidental, diagnostic or therapeutic. Such patients may be unresponsive to the usual doses of epinephrine used to treat the allergic reaction. | ||
| Toxicity | LD50=2000-3000 mg/kg(orally in mice). Symptoms of an atenolol overdose include a slow heart beat, shortness of breath, fainting, dizziness, weakness, confusion, nausea, and vomiting. | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 2-[4-[2-hydroxy-3-(1-methylethylamino)propoxy]phenyl]ethanamide | ||
| Chemical Formula | C14H22N2O3 | ||
| Molecular Weight | 266.336 g/mol | ||
| Smiles String | CC(C)NCC(COC1=CC=C(C=C1)CC(=O)N)O | ||
| Melting Point | 146-148°C | ||
| Water Solubility | 13.5 mg/mL | ||
| State | crystals | ||
| LogP/Hphobicity | 1.256 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | hepatic (minimal) | ||
| Half Life | 6-7 hours | ||
| Protein Binding [%] | plasma protein binding is 6-16 % | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Atenolol.html http://www.rxlist.com/cgi/generic/atenolol.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00172 | ||
| CAS Registry Number | 29122-68-7 | ||
| KEGG Compound ID | C06833 | ||
| PubChem ID | SID:176216 | ||
| PharmGKB ID | Not Available | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 828793 |
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