Atenolol drug data and news

Atenolol drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name Atenolol
Brand Names/Synonyms Aircrit; Alinor; Altol; Anselol; Antipressan; Apo-Atenolol; Atcardil; Atecard; Atehexal; Atenblock; Atendol; Atenet; Ateni; Atenil; Atenol; Atenol 1a Pharma; Atenol Acis; Atenol Al; Atenol Atid; Atenol Cophar; Atenol Ct; Atenol Fecofar; Atenol Gador; Atenol Genericon; Atenol Gnr; Atenol Heumann; Atenol Msd; Atenol Nm Pharma; Atenol Nordic; Atenol Pb; Atenol Quesada; Atenol Stada; Atenol Tika; Atenol Trom; Atenol von Ct; Atenol-Mepha; Atenol-Ratiopharm; Atenol-Wolff; Atenolin; Atenolol; Atenomel; Atereal; Aterol; Betablok; Betacard; Betasyn; Betatop Ge; Blocotenol; Blokium; CCRIS 4196; Cardaxen; Cardiopress; Corotenol; Cuxanorm; Duraatenolol; Duratenol; Evitocor; Farnormin; Felo-Bits; HSDB 6526; Hipres; Hypoten; Ibinolo; Internolol; Jenatenol; Juvental; Lo-Ten; Loten; Lotenal; Myocord; Normalol; Normiten; Noten; Oraday; Ormidol; Panapres; Plenacor; Premorine; Prenolol; Prenormine; Prinorm; Scheinpharm Atenol; Seles Beta; Selobloc; Serten; Servitenol; Stermin; Tenidon; Teno-Basan; Tenobloc; Tenoblock; Tenolol; Tenoprin; Tenoretic; Tenormin; Tenormine; Tensimin; Tredol; Unibloc; Uniloc; Vascoten; Vericordin; Wesipin; Xaten
Indication For the management of hypertention and long-term management of patients with angina pectoris
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Description Not Available
Pharmacology Atenolol, a competitive beta(1)-selective adrenergic antagonist, has the lowest lipid solubility of this drug class. Although it is similar to metoprolol, atenolol differs from pindolol and propranolol in that it does not have intrinsic sympathomimetic properties or membrane-stabilizing activity. Atenolol is used alone or with chlorthalidone in the management of hypertension and edema.
Mechanism Of Action Like metoprolol, atenolol competes with sympathomimetic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart and vascular smooth muscle, inhibiting sympathetic stimulation. This results in a reduction in resting heart rate, cardiac output, systolic and diastolic blood pressure, and reflex orthostatic hypotension. Higher doses of atenolol also competitively block beta(2)-adrenergic responses in the bronchial and vascular smooth muscles.
Atenolol News
(When available)

Glaxo Loses US Court Bid to Block Generic Flonase (Update1)  06 Mar 2006
Flonase also is different from many other nasal sprays because its active ingredient, fluticasone propionate, is held in a suspension, which is a solid ... - Bloomberg

Roxane Laboratories, Inc. Announces the Launch of Fluticasone ...  Feb 23, 2006
...today announced the approval of Fluticasone Propionate Nasal Spray, 50mcg. ... Annual sales of Fluticasone Propionate Nasal Spray are approximately $1.2 billion 1. ... - PharmaLive.com (press release),

GlaxoSmithKline blocks sales of competitor's generic Flonase  Feb 27, 2006
The order applies to both Roxane Laboratories Inc.'s Fluticasone Propionate Nasal Spray, which the Food and Drug Administration approved Wednesday, and Par ... - Columbus Ledger-Enquirer,

First Generic Version of Flonase Approved  Feb 23, 2006
The Food and Drug Administration (FDA) approved Fluticasone Propionate Nasal Spray, the first generic version of the brand name drug Flonase, giving American ... - Kansas City infoZine,

FDA Approves First Generic Version of Flonase  Feb 22, 2006
February 22, 2006, The Food and Drug Administration (FDA) today approved Fluticasone Propionate Nasal Spray, the first generic version of the brand name drug ... - WebWire (press release),

GlaxoSmithKline blocks sales of generic competitor to its Flonase ...  Feb 24, 2006
The order applies to both Columbus, Ohio-based Roxane Laboratories Inc.'s Fluticasone Propionate Nasal Spray, which the Food and Drug Administration approved ... - Akron Beacon Journal,

FDA Approves Generic Version Of Flonase Nasal Spray  Feb 23, 2006
...(AHN) - The US Food and Drug Administration on Thursday approves Fluticasone Propionate Nasal Spray, the first generic version of the brand name drug Flonase. ... - All Headline News

First Generic of Glaxo's Flonase is Approved  Feb 24, 2006
...allowing Roxane, a subsidiary of Boehringer Ingelheim, to apply for approval of its generic product containing the same active ingredient fluticasone propionate ... - International News Service,

First Generic Version of Flonase Approved  Feb 23, 2006
Like GlaxoSmithKline's brand-name equivalent, the generic form called Fluticasone Propionate Nasal Spray is an inhaled corticosteroid. ... - Forbes

GSK blocks generic Flonase in USA, for now  Feb 27, 2006
Flonase (fluticasone propionate) nasal spray brought in worldwide sales of £656 million ($1.14bn) last year, £506 million of which came from the US market ... - Pharma Times (subscription),

FDA OKs Generic Version of Flonase  Feb 22, 2006
The generic product is called fluticasone propionate nasal spray. It's approved for use in adults and children who are at least 4 years old. ... - WebMD

FDA Approves First Generic Form of Flonase  Feb 23, 2006
Like GlaxoSmithKline's brand-name equivalent, the new generic (Fluticasone Propionate Nasal Spray) is an inhaled corticosteroid approved for adults and ... - WFIE-TV,

Par Pharmaceutical Reports Sales and Earnings for 2005  Feb 28, 2006
...had earlier announced that it entered into a supply and distribution agreement with GlaxoSmithKline (GSK) in the US to distribute fluticasone propionate nasal ... - MSN Money

FDA approves generic version of Flonase  Feb 22, 2006
Regulators approve the first generic version of GlaxoSmithKline's treatment for stuffy noses, Roxane Labs to market generic version called fluticasone. ... - CNN/Money

FDA approves generic competitor to Glaxo's Flonase  Feb 22, 2006
...the drug. The US Food and Drug Administration approved a generic nasal spray called fluticasone on Wednesday. Private pharmaceutical ... - Raleigh Triangle Business Journal,

Par Pharmaceutical Halts Shipment of Generic Flonase(R)  Feb 24, 2006
Drug Administration's (FDA) final decision approving an abbreviated new drug application (ANDA) for a generic version of Flonase (fluticasone propionate) Nasal ... - Finanzen.net,

Generic Flonase blocked in court  Feb 25, 2006
The order applies to both Roxane Laboratories' fluticasone propionate nasal spray, which the Food and Drug Administration approved Wednesday, and Par ... - Fort Worth Star Telegram,

FDA approves generic version of popular allergy drug Flonase  Feb 28, 2006
...alternative. Fluticasone Propionate Nasal Spray is the first generic version of Flonase, which has annual sales of more than $1 billion. ... - Wilkes Barre Times-Leader,

Doctors required to reveal links with drug firms  Feb 12, 2006
...transparent after The Herald last summer highlighted the case of a child who died after being prescribed high doses of a steroid called fluticasone, used in ... - The Herald,

Par Pharmaceutical Begins Shipment of Generic Flonase(R)  Feb 23, 2006
...that it has entered into a supply and distribution agreement with GlaxoSmithKline (GSK) in the United States to distribute fluticasone propionate aqueous nasal ... - PR Newswire (press release),

Steroid puff best for kids with persistent asthma  Feb 10, 2006
NEW YORK (Reuters Health) - In a study of children with mild-to-moderate persistent asthma, treatment with fluticasone (Flovent), an inhaled steroid, was ... - Reuters.uk,

Boehringer Ingelheim Announces 48-week Results from Aptivus(R) ...  Feb 9, 2006
A drug interaction study in healthy subjects has shown that ritonavir significantly increases plasma fluticasone propionate exposures. ... - PR Newswire (press release),

UPDATE 1-US FDA approves generic version of GSK nasal spray  Feb 22, 2006
Privately held Roxane Laboratories will market the generic version called fluticasone, the US Food and Drug Administration said in a statement. ... - Reuters

Par Pharma halts generic Flonase shipments after GSK wins ...  Feb 24, 2006
Spring Valley, Pa.-based Par Pharma said it has subsequently halted all shipments of fluticasone propionate nasal spray and will take other steps necessary to ... - Forbes

National Briefing  Feb 24, 2006
...spokeswoman for the company. The order applies to the fluticasone propionate nasal spray made by Roxane Laboratories Inc. and a generic ... - New York Times,

FDA approves generic version of Flonase nasal spray  Feb 22, 2006
...dollars. The generic version of the drug (Fluticasone Propionate Nasal Spray) is made by Roxane Laboratories, of Columbus, Ohio. ... - Ohio News Network,

Another generic rises against Glaxo  Feb 23, 2006
The announcement comes the day after Ohio-based Roxane Laboratories received final approval of fluticasone, a generic version of Glaxo's blockbuster nasal ... - Raleigh Triangle Business Journal,

FDA approves generic Flonase spray  Feb 24, 2006
By JAN JARVIS. Fluticasone propionate nasal spray, a generic version of GlaxoSmithKline's Flonase, won approval Wednesday from the Food and Drug Administration. ... - Fort Worth Star Telegram,

Judge orders halt to sales of generic Flonase  Feb 24, 2006
In a statement today, Par said it was halting shipments of its version of Flonase, known by the generic name fluticasone propionate, a nasal spray. ... - philly.com,

GlaxoSmithKline blocks sales of generic competitor to Flonase  Feb 26, 2006
The order applies to Columbus (Ohio)-based Roxane Laboratories' Fluticasone Propionate Nasal Spray, which the Food and Drug Administration approved Wednesday. ... - Newswatch 50,

GlaxoSmithKline "in-line," estimates revised  Feb 24, 2006
...research note published this morning, the analysts mention that the US FDA has approved the generic version of the company's Flonase, a fluticasone nasal spray ... - New Ratings

Lundergan group buys Continental Inn  Feb 24, 2006
The order applies to both Roxane Laboratories Inc.’s Fluticasone Propionate Nasal Spray, which the Food and Drug Administration approved Wednesday, and Par ... - Kentucky.com,

GlaxoSmithKline: Pliva Deal to Boost R&D  Feb 15, 2006
Indeed, sales from these brands - Flovent (fluticasone), Seretide (salmeterol, fluticasone) and Serevent (salmeterol) - accounted for 21.3% of the company's ... - International News Service,

Generic nasal spray sales blocked  Feb 25, 2006
The order applies to both Roxane Laboratories’ Fluticasone Propionate Nasal Spray, which the Food and Drug Administration approved Wednesday, and Par ... - Sioux Falls Argus Leader,

Asthma treatment led to girl’s death  Feb 12, 2006
Doctors recommended she took inhaled steroids and when Emma was 18 months old she was given fluticasone, which is branded by one company as Flixotide. ... - The Herald,

GSK's Flonase facing generic rival in USA  Feb 23, 2006
Flonase (fluticasone) brought in worldwide sales of £656 million ($1.14bn) last year, £506 million of which came from the US market, but saw its last US ... - Pharma Times (subscription),

Cash relief in store for allergy sufferers  Feb 24, 2006
...relief. The Food and Drug Administration has approved fluticasone propionate, a generic version of Flonase nasal spray. Normally ... - WFAA (subscription),

SNP urges registers of interest for all health authorities  Feb 13, 2006
...to be clearer following reports last summer of a five-year-old girl who died after being prescribed high dosages of a drug called fluticasone, used in the ... - The Herald,

Sepracor: arformoterol offers relief  Feb 16, 2006
...bronchodilators and the fact the many patients with more severe COPD use combination products, such as GlaxoSmithKline's Advair (fluticasone and salmeterol). ... - Pharmaceutical Business Review

SCHWARZ PHARMA /Full Year Report 2005  Feb 17, 2006
This growth was particularly driven by the promoted drugs Rifun® (pantoprazole; +33%), Atmadisc® (fluticasone/salmeterol; +22%) and Provas® (valsartan; +10 ... - PharmaLive.com (press release),

2005 - the year of recovery for GSK  Feb 9, 2006
Several of GSK's drugs turned in solid revenue growth for 2005: the company's top-selling product, Seretide/Advair (salmeterol and fluticasone) for asthma ... - Pharma Times (subscription),

Boehringer Ingelheim Announces 48-week Results from Aptivus(R) ...  09 Feb 2006
A drug interaction study in healthy subjects has shown that ritonavir significantly increases plasma fluticasone propionate exposures. ... - PR Newswire (press release),

2005 - the year of recovery for GSK  09 Feb 2006
Several of GSK's drugs turned in solid revenue growth for 2005: the company's top-selling product, Seretide/Advair (salmeterol and fluticasone) for asthma ... - Pharma Times (subscription),

Inhaled Corticosteroids Most Effective for Persistent Asthma in ...  Jan 10, 2006
Response Profiles to Fluticasone and Montelukast in Mild-to-Moderate Persistent Childhood Asthma is featured in the January 2006 issue of the Journal of ... - DG News

ICS Most Effective For Persistent Asthma In Children  Jan 11, 2006
Response Profiles to Fluticasone and Montelukast in Mild-to-Moderate Persistent Childhood Asthma is featured in the January 2006 issue of the Journal of ... - Science Daily (press release)

Breathe Easier!  Jan 22, 2006
...year, a paper was presented at the annual American Association of Equine Practitioners' convention reporting on another inhaled corticosteroid, fluticasone. ... - TheHorse.com,

Inhaled Steroid Controls Asthma Better Than Oral Agent  Jan 12, 2006
Their study compared the inhaled corticosteroid Flovent (fluticasone) with the oral leukotriene receptor antagonist Singulair (montelukast) for asthma control ... - CNN

Study targets better asthma treatments  Jan 17, 2006
Researchers administered an inhaled corticosteroid (fluticasone propionate) twice daily or an leukotriene receptor antagonist (montelukast) nightly to more ... - Monsters and Critics.com,

SkyePharma will not merge with Innovata  Jan 12, 2006
...its cash position as it continues a costly effort to bring a combination inhaled product for asthma - Flutiform (formoterol plus fluticasone) - to market. ... - Pharma Times (subscription),

Study Compares Kids' Asthma Drugs  Jan 19, 2006
The children were divided into two groups. One group received an inhaled corticosteroid (fluticasone propionate) twice daily or an LTRA (montelukast) nightly. ... - Forbes

AstraZeneca's Symbicort gives asthma patients the power to get ...  Jan 13, 2006
With the SMART approach, Symbicort is used to provide a stable dosing regime, as with GlaxoSmithKline's Seretide (fluticasone/salmeterol), but the dose can be ... - Pharmaceutical Business Review

Teen should wait on pill - and on sex  Jan 24, 2006
...each day. The drug, fluticasone, reduces inflammation and eases symptoms of an itchy, runny nose, sneezing and stuffy sinuses. First ... - New York Newsday,

Dosage Forms Tablets as 25, 50 and 100 mg tablets for oral adminstration, I.V. Injection
Drug_Category Sympatholytics; Antihypertensive Agents; Antiarrhythmic Agents; Adrenergic Agents; ATC:C07AB03; ATC:C07AB11
Absorption oral dose if rapid and consisten but incomplete. Approximately 50% of an oral dose is absorbed from the gastrointestinal tract, the remainder being excreted unchanged in the feces.
Interactions Interactions for Atenolol:

Catecholamine-depleting drugs (eg, reserpine) may have an additive effect when given with beta-blocking agents. Patients treated with TENORMIN plus a catecholamine depletor should therefore be closely observed for evidence of hypotension and/or marked bradycardia which may produce vertigo, syncope, or postural hypotension.

Calcium channel blockers may also have an additive effect when given with TENORMIN .

Beta blockers may exacerbate the rebound hypertension which can follow the withdrawal of clonidine. If the two drugs are coadministered, the beta blocker should be withdrawn several days before the gradual withdrawal of clonidine. If replacing clonidine by beta-blocker therapy, the introduction of beta blockers should be delayed for several days after clonidine administration has stopped.

Concomitant use of prostaglandin synthase inhibiting drugs, eg, indomethacin, may decrease the hypotensive effects of beta blockers.

Information on concurrent usage of atenolol and aspirin is limited. Data from several studies, ie, TIMI-II, ISIS-2, currently do not suggest any clinical interaction between aspirin and beta blockers in the acute myocardial infarction setting.

While taking beta blockers, patients with a history of anaphylactic reaction to a variety of allergens may have a more severe reaction on repeated challenge, either accidental, diagnostic or therapeutic. Such patients may be unresponsive to the usual doses of epinephrine used to treat the allergic reaction.

Toxicity LD50=2000-3000 mg/kg(orally in mice). Symptoms of an atenolol overdose include a slow heart beat, shortness of breath, fainting, dizziness, weakness, confusion, nausea, and vomiting.
Organisms Affected Humans and other mammals
Chemical IUPAC Name 2-[4-[2-hydroxy-3-(1-methylethylamino)propoxy]phenyl]ethanamide
Chemical Formula C14H22N2O3
Molecular Weight 266.336 g/mol
Smiles String CC(C)NCC(COC1=CC=C(C=C1)CC(=O)N)O
Melting Point 146-148°C
Water Solubility 13.5 mg/mL
State crystals
LogP/Hphobicity 1.256
Isoelectric Point Not Available
Biotransformation hepatic (minimal)
Half Life 6-7 hours
Protein Binding [%] plasma protein binding is 6-16 %
RxList Link RXlist
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Drug Reference http://www.drugs.com/cons/Atenolol.html
http://www.rxlist.com/cgi/generic/atenolol.htm
Drug Type Approved Drug
Accession No APRD00172
CAS Registry Number 29122-68-7
KEGG Compound ID C06833
PubChem ID SID:176216
PharmGKB ID Not Available
SwissProt ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] 828793

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