Arsenic Trioxide drug data and news

Arsenic Trioxide drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name Arsenic Trioxide
Brand Names/Synonyms Acide Arsenieux; Acide Arsenieux [French]; Anhydride Arsenieux; Anhydride Arsenieux [French]; Arseni Trioxydum; Arsenic Blanc; Arsenic Blanc [French]; Arsenic Oxide; Arsenic Oxidearsenous Trioxide; Arsenic Sesquioxide; Arsenic Trioxide; Arsenic Trioxide [Jan]; Arsenic Trioxide [Un1561] [Poison]; Arsenic, White; Arsenicoxideelecgrwhitepowder; Arsenicoxideprimarystandardacswhitepowder; Arsenicum Album; Arsenigen Saure; Arsenigen Saure [German]; Arsenious Acid; Arsenious Acid Anhydride; Arsenious Oxide; Arsenious Trioxide; Arsenite; Arsenolite; Arsenous Acid; Arsenous Acid Anhydride; Arsenous Anhydride; Arsenous Oxide; Arsenous Oxide Anhydride; Arsenous Oxide [Iso]; Arsentrioxide; Arsodent; CCRIS 5455; Caswell No. 059; Claudelite; Claudetite; Crude Arsenic; Di-Arsenic Trioxide; Diarsenic Trioxide; Diarsonic Trioxide; HSDB 419; Oxyde Arsenieux [Iso-French]; Poison Flour; Rcra Waste No. P012; Rcra Waste Number P012; Trisenox; UN 1561; White Arsenic
Indication For induction of remission and consolidation in patients with acute promyelocytic leukemia (APL), and whose APL is characterized by the presence of the t(15;17) translocation or PML/RAR-alpha gene expression
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Description Not Available
Pharmacology Arsenic Trioxide is indicated for induction of remission and consolidation in patients with acute promyelocytic leukemia (APL) who are refractory to, or have relapsed from, retinoid and anthracycline chemotherapy.
Mechanism Of Action The mechanism of action of Arsenic Trioxide is not completely understood. Arsenic trioxide causes morphological changes and DNA fragmentation characteristic of apoptosis in NB4 human promyelocytic leukemia cells in vitro. Arsenic trioxide also causes damage or degradation of the fusion protein PML/RAR-alpha.
Arsenic Trioxide News
(When available)

Old drugs find novel anti-cancer applications  Feb 14, 2006
...not a common item in health food stores, but organic arsenic appears to be a whole lot better as an anti-cancer drug than its inorganic cousin, Arsenic Trioxide ... - Xagena.it,

Cephalon Reports Outstanding Financial Results for 2005  Feb 14, 2006
The company currently markets four proprietary products in the United States: PROVIGIL, GABITRIL, ACTIQ and TRISENOX(R) (arsenic trioxide) injection, and ... - MSN Money

Imperial not interested in performance bond idea  Feb 17, 2006
He pointed to projects like the Distant Early Warning line sites all across the North, and the massive amount of poisonous arsenic trioxide left at the Giant ... - CBC North,

Cephalon Reports Outstanding Financial Results for 2005  Feb 14, 2006
The company currently markets four proprietary products in the United States: PROVIGIL, GABITRIL, ACTIQ and TRISENOX® (arsenic trioxide) injection, and ... - Yahoo! News (press release)

Cephalon, Inc. Provides Update on Regulatory Status of NUVIGIL(TM)  Feb 1, 2006
States: PROVIGIL, GABITRIL(R) (tiagabine hydrochloride), ACTIQ(R) (oral transmucosal fentanyl citrate) [C-II] and TRISENOX(R) (arsenic trioxide) injection and ... - PR Newswire (press release),

Cephalon, Inc. Announces Agreements With Barr Laboratories, Inc. ...  Feb 1, 2006
...markets four proprietary products in the United States: PROVIGIL, GABITRIL® (tiagabine hydrochloride), ACTIQ and TRISENOX® (arsenic trioxide) injection, and ... - Yahoo! News (press release)

Cephalon, Inc. Announces Agreements With Barr Laboratories, Inc. ...  Feb 1, 2006
...four proprietary products in the United States: PROVIGIL, GABITRIL(R) (tiagabine hydrochloride), ACTIQ and TRISENOX(R) (arsenic trioxide) injection, and more ... - PR Newswire (press release),

ZIOPHARM Initiates ZIO-101 Phase I/II Myeloma Study; Company Meets ...  Jan 31, 2006
...an ongoing phase I trial suggest ZIO-101 can be given at significantly higher doses, with no significant toxicity, compared to arsenic trioxide, an inorganic ... - Genetic Engineering News,

Cephalon, Inc. Provides Update on Regulatory Status of NUVIGIL  Feb 2, 2006
States: PROVIGIL, GABITRIL(R) (tiagabine hydrochloride), ACTIQ(R) (oral transmucosal fentanyl citrate) [C-II] and TRISENOX(R) (arsenic trioxide) injection and ... - PharmaLive.com (press release),

Horst Witzel, Dr.-Ing., to Retire From Cephalon Board of Directors  Jan 31, 2006
...modafinil) [C-IV], GABITRIL® (tiagabine hydrochloride), ACTIQ® (oral transmucosal fentanyl citrate) [C-II] and TRISENOX® (arsenic trioxide) injection, and ... - Yahoo! News (press release)

Cephalon, Inc. Announces Agreements With Barr Laboratories, Inc. ...  Feb 1, 2006
...markets four proprietary products in the United States: PROVIGIL, GABITRIL® (tiagabine hydrochloride), ACTIQ and TRISENOX® (arsenic trioxide) injection, and ... - Yahoo! News (press release)

Cephalon, Inc. Announces Agreements With Barr Laboratories, Inc. ...  Feb 1, 2006
...four proprietary products in the United States: PROVIGIL, GABITRIL(R) (tiagabine hydrochloride), ACTIQ and TRISENOX(R) (arsenic trioxide) injection, and more ... - PR Newswire (press release),

Scientific Advances on Three Lead Cephalon Oncology Compounds to ...  Dec 8, 2005
At ASH, researchers also will report data from investigator- sponsored studies of TRISENOX(R) (arsenic trioxide) injection, the company's marketed anti-cancer ... - PR Newswire (press release),

Scientific Advances on Three Lead Cephalon Oncology Compounds to ...  Dec 8, 2005
At ASH, researchers also will report data from investigator- sponsored studies of TRISENOX® (arsenic trioxide) injection, the company's marketed anti-cancer ... - Yahoo! News (press release)

Cephalon, Inc. Announces Agreement with Teva Pharmaceutical ...  Dec 9, 2005
States: PROVIGIL, GABITRIL(R) (tiagabine hydrochloride), ACTIQ(R) (oral transmucosal fentanyl citrate) [C-II] and TRISENOX(R) (arsenic trioxide) injection, and ... - PR Newswire (press release),

Recycled or revamped therapeutics find novel anti-cancer ...  Nov 16, 2005
...not a common item in health food stores, but organic arsenic appears to be a whole lot better as an anti-cancer drug than its inorganic cousin, arsenic trioxide ... - EurekAlert (press release),

ZIOPHARM Oncology Announces ZIO-101 Phase I Data Presented at AACR ...  Nov 16, 2005
...a novel organic arsenic, has demonstrated safety at doses approximately 25 times higher than the currently approved dose for arsenic trioxide, an inorganic ... - Genetic Engineering News,

ZIOPHARM Oncology Announces ZIO-101 Data Published in Blood  Nov 21, 2005
In this study, the cytotoxic properties and mechanism of action of ZIO-101 were compared to arsenic trioxide (ATO) in four multiple myeloma cell lines. ... - Business Wire (press release),

Source: Cephalon, Inc.; Zeneus Holdings Limited  Dec 5, 2005
...modafinil) [C-IV], GABITRIL® (tiagabine hydrochloride), ACTIQ® (oral transmucosal fentanyl citrate) [C-II] and TRISENOX® (arsenic trioxide) injection, and ... - Yahoo! News (press release)

Siblings stay strong  Nov 13, 2005
Truman had tried many treatments, including chemotherapy, and took several drugs as part of drug testing trials, like arsenic trioxide, which slows the growth ... - Marion Chronicle Tribune,

REVIEW : Venomous Earth exposes poison power of arsenic  Sep 25, 2005
...enthralling. Arsenic trioxide, the so-called "white arsenic," is colorless, odorless, almost tasteless and slightly soluble. Until ... - Arkansas Democrat-Gazette (subscription),

FDA Extends PDUFA Date for VIVITREX(R) to December 30, 2005 ...  Sep 20, 2005
C-IV), GABITRIL(R) (tiagabine hydrochloride), ACTIQ(R) (oral transmucosal fentanyl citrate) (C-II) and TRISENOX(R) (arsenic trioxide) injection, and more than ... - Genetic Engineering News,

FDA Extends PDUFA Date for VIVITREX(R) to December 30, 2005 ...  Sep 20, 2005
...modafinil) (C-IV), GABITRIL(R) (tiagabinehydrochloride), ACTIQ(R) (oral transmucosal fentanyl citrate) (C-II)and TRISENOX(R) (arsenic trioxide) injection, and ... - Finanzen.net,

Cephalon Receives FDA Approval to Market Sugar-Free Formulation of ...  Sep 12, 2005
...products in the United States: PROVIGIL(R) (modafinil) [C-IV], GABITRIL(R) (tiagabine hydrochloride), ACTIQ, and TRISENOX(R) (arsenic trioxide) injection, and ... - PharmaLive.com (press release),

Cephalon Receives FDA Approval to Market Sugar-Free Formulation of ...  Sep 12, 2005
...products in the United States: PROVIGIL® (modafinil) [C-IV], GABITRIL® (tiagabine hydrochloride), ACTIQ, and TRISENOX® (arsenic trioxide) injection, and ... - Yahoo! News (press release)

Cephalon Files New Drug Application for OraVescent(R) Fentanyl for ...  Sep 6, 2005
...four proprietary products in the United States: PROVIGIL(R) (modafinil) Tablets [C-IV], GABITRIL, ACTIQ, and TRISENOX(R) (arsenic trioxide) injection, and more ... - PR Newswire (press release),

Cephalon, Inc. Announces Agreement With McNeil Consumer & ...  Sep 1, 2005
States: PROVIGIL, GABITRIL(R) (tiagabine hydrochloride) ACTIQ(R) (oral transmucosal fentanyl citrate) [C-II] and TRISENOX(R) (arsenic trioxide), and more than ... - PR Newswire (press release),

Cephalon Receives Approval to Market Modafinil for Shift Work ...  Aug 30, 2005
PROVIGIL(R), GABITRIL(R) (tiagabine hydrochloride), ACTIQ(R) (oral transmucosal fentanyl citrate) [C-II] and TRISENOX(R) (arsenic trioxide) injection and more ... - PR Newswire (press release),

Cephalon Board Member Gail Wilensky Appointed to World Health ...  Aug 25, 2005
...modafinil) [C-IV], GABITRIL® (tiagabine hydrochloride), ACTIQ® (oral transmucosal fentanyl citrate) [C-II] and TRISENOX® (arsenic trioxide) injection, and ... - Yahoo News (press release)

New England Journal of Medicine Publishes First Clinical Study of ...  Aug 4, 2005
States: PROVIGIL, GABITRIL(R) (tiagabine hydrochloride), ACTIQ(R) (oral transmucosal fentanyl citrate) [C-II] and TRISENOX(R) (arsenic trioxide) injection and ... - Forbes

Retinoic Acid and Idarubicin Effective for Pediatric Acute ...  Aug 5, 2005
..."Agents that are more specific for APL and/or less globally cytotoxic, including arsenic trioxide and gemtuzumab ozogomycin, are already available," Dr ... - Cancerpage.com

Freezing arsenic a good solution, for now: Dion  Aug 3, 2005
...process. Besides the surface clean up, there are 237,000 tonnes of toxic arsenic trioxide dust stored in chambers under the mine. ... - CBC North

Concrete measures to remediate 97 contaminated federal sites - The ...  Aug 2, 2005
The main issue at Giant is the 237,000 tonnes of arsenic trioxide dust stored underground at the site. The dust was created during the gold production process. ... - CNW Telbec (Communiqués de presse)

Cephalon Reports Continued Strong Growth in Second Quarter  Aug 2, 2005
Finally, the company acquired TRISENOX® (arsenic trioxide) injection, a marketed product that accelerates the company's entry into the oncology market. ... - Yahoo News (press release)

Cephalon Reports Continued Strong Growth in Second Quarter  Aug 2, 2005
Finally, the company acquired TRISENOX(R) (arsenic trioxide) injection, a marketed product that accelerates the company's entry into the oncology market. ... - PharmaLive.com (press release)

AE2S adds Long to its Moorhead office  Jul 23, 2005
Long is currently working at the company’s Moorhead office on the North Dakota Arsenic Trioxide Superfund Project in southeastern North Dakota. ... - In-Forum (subscription)

King George III's Madness Worsened by Arsenic  Jul 21, 2005
...researchers. Still, they say it's impossible to be certain of that, since arsenic trioxide is also used as an insecticide in preservation. ... - FOX News

Cephalon, Inc. Completes Acquisition of TRISENOX From Cell ...  Jul 19, 2005
Inc. announced today that it has completed its acquisition of TRISENOX(R) (arsenic trioxide) injection from Cell Therapeutics, Inc. ... - PharmaLive.com (press release)

Cephalon, Inc. Completes Acquisition of TRISENOX(R) From Cell ...  Jul 19, 2005
...(Nasdaq: CEPH - News) announced today that it has completed its acquisition of TRISENOX® (arsenic trioxide) injection from Cell Therapeutics, Inc. ... - Yahoo News (press release)

NEWS RELEASE  Jul 19, 2005
Echelon, Inc. (Nasdaq: CEPH) announced today that it has completed its acquisition of TRISENOX® (arsenic trioxide) injection from Cell Therapeutics, Inc. ... - Financial News USA (press release)

Final chapter for Yellowknife's Giant Mine  Jul 18, 2005
...of gold mining. That includes 237,000 tonnes of toxic arsenic trioxide dust stored underground at the mine. Indian Affairs plans ... - CBC North

Dosage Forms TABLET
Drug_Category Antineoplastic Agents; Homeopathic Agents; ATC:L01XX27
Absorption Not Available
Interactions Drug Interactions for Arsenic Trioxide:

No formal assessments of pharmacokinetic drug-drug interactions between TRISENOXô and other agents have been conducted. Caution is advised when TRISENOXô is coadministered with other medications that can prolong the QT interval (e.g. certain antiarrhythmics or thioridazine) or lead to electrolyte abnormalities (such as diuretics or amphotericin B).

Toxicity Not Available
Organisms Affected Humans and other mammals
Chemical IUPAC Name Not Available
Chemical Formula As2O3
Molecular Weight 197.841 g/mol
Smiles String O=[As]O[As]=O
Melting Point Not Available
Water Solubility Not Available
State Solid
LogP/Hphobicity Not Available
Isoelectric Point Not Available
Biotransformation Not Available
Half Life Not Available
Protein Binding [%] 75% bound-tissue
RxList Link RXlist
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Drug Reference http://www.drugs.com/cons/Arsenic_Trioxide.html
http://www.rxlist.com/cgi/generic2/arsenic.htm
Drug Type Approved Drug
Accession No APRD00171
CAS Registry Number 1327-53-3
KEGG Compound ID Not Available
PubChem ID SID:14549
PharmGKB ID PA448486
SwissProt ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] 718777

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