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Arsenic Trioxide
drug data and news
Arsenic Trioxide drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Arsenic Trioxide | ||
| Brand Names/Synonyms | Acide Arsenieux; Acide Arsenieux [French]; Anhydride Arsenieux; Anhydride Arsenieux [French]; Arseni Trioxydum; Arsenic Blanc; Arsenic Blanc [French]; Arsenic Oxide; Arsenic Oxidearsenous Trioxide; Arsenic Sesquioxide; Arsenic Trioxide; Arsenic Trioxide [Jan]; Arsenic Trioxide [Un1561] [Poison]; Arsenic, White; Arsenicoxideelecgrwhitepowder; Arsenicoxideprimarystandardacswhitepowder; Arsenicum Album; Arsenigen Saure; Arsenigen Saure [German]; Arsenious Acid; Arsenious Acid Anhydride; Arsenious Oxide; Arsenious Trioxide; Arsenite; Arsenolite; Arsenous Acid; Arsenous Acid Anhydride; Arsenous Anhydride; Arsenous Oxide; Arsenous Oxide Anhydride; Arsenous Oxide [Iso]; Arsentrioxide; Arsodent; CCRIS 5455; Caswell No. 059; Claudelite; Claudetite; Crude Arsenic; Di-Arsenic Trioxide; Diarsenic Trioxide; Diarsonic Trioxide; HSDB 419; Oxyde Arsenieux [Iso-French]; Poison Flour; Rcra Waste No. P012; Rcra Waste Number P012; Trisenox; UN 1561; White Arsenic | ||
| Indication | For induction of remission and consolidation in patients with acute promyelocytic leukemia (APL), and whose APL is characterized by the presence of the t(15;17) translocation or PML/RAR-alpha gene expression | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Arsenic Trioxide is indicated for induction of remission and consolidation in patients with acute promyelocytic leukemia (APL) who are refractory to, or have relapsed from, retinoid and anthracycline chemotherapy. | ||
| Mechanism Of Action | The mechanism of action of Arsenic Trioxide is not completely understood. Arsenic trioxide causes morphological changes and DNA fragmentation characteristic of apoptosis in NB4 human promyelocytic leukemia cells in vitro. Arsenic trioxide also causes damage or degradation of the fusion protein PML/RAR-alpha. | ||
| Arsenic Trioxide News (When available) |
Old drugs find novel anti-cancer applications Feb 14, 2006 Cephalon Reports Outstanding Financial Results for 2005 Feb 14, 2006 Imperial not interested in performance bond idea Feb 17, 2006 Cephalon Reports Outstanding Financial Results for 2005 Feb 14, 2006 Cephalon, Inc. Provides Update on Regulatory Status of NUVIGIL(TM) Feb 1, 2006 Cephalon, Inc. Announces Agreements With Barr Laboratories, Inc. ... Feb 1, 2006 Cephalon, Inc. Announces Agreements With Barr Laboratories, Inc. ... Feb 1, 2006 ZIOPHARM Initiates ZIO-101 Phase I/II Myeloma Study; Company Meets ... Jan 31, 2006 Cephalon, Inc. Provides Update on Regulatory Status of NUVIGIL Feb 2, 2006 Horst Witzel, Dr.-Ing., to Retire From Cephalon Board of Directors Jan 31, 2006 Cephalon, Inc. Announces Agreements With Barr Laboratories, Inc. ... Feb 1, 2006 Cephalon, Inc. Announces Agreements With Barr Laboratories, Inc. ... Feb 1, 2006 Scientific Advances on Three Lead Cephalon Oncology Compounds to ... Dec 8, 2005 Scientific Advances on Three Lead Cephalon Oncology Compounds to ... Dec 8, 2005 Cephalon, Inc. Announces Agreement with Teva Pharmaceutical ... Dec 9, 2005 Recycled or revamped therapeutics find novel anti-cancer ... Nov 16, 2005 ZIOPHARM Oncology Announces ZIO-101 Phase I Data Presented at AACR ... Nov 16, 2005 ZIOPHARM Oncology Announces ZIO-101 Data Published in Blood Nov 21, 2005 Source: Cephalon, Inc.; Zeneus Holdings Limited Dec 5, 2005 Siblings stay strong Nov 13, 2005 REVIEW : Venomous Earth exposes poison power of arsenic Sep 25, 2005 FDA Extends PDUFA Date for VIVITREX(R) to December 30, 2005 ... Sep 20, 2005 FDA Extends PDUFA Date for VIVITREX(R) to December 30, 2005 ... Sep 20, 2005 Cephalon Receives FDA Approval to Market Sugar-Free Formulation of ... Sep 12, 2005 Cephalon Receives FDA Approval to Market Sugar-Free Formulation of ... Sep 12, 2005 Cephalon Files New Drug Application for OraVescent(R) Fentanyl for ... Sep 6, 2005 Cephalon, Inc. Announces Agreement With McNeil Consumer & ... Sep 1, 2005 Cephalon Receives Approval to Market Modafinil for Shift Work ... Aug 30, 2005 Cephalon Board Member Gail Wilensky Appointed to World Health ... Aug 25, 2005 New England Journal of Medicine Publishes First Clinical Study of ... Aug 4, 2005 Retinoic Acid and Idarubicin Effective for Pediatric Acute ... Aug 5, 2005 Freezing arsenic a good solution, for now: Dion Aug 3, 2005 Concrete measures to remediate 97 contaminated federal sites - The ... Aug 2, 2005 Cephalon Reports Continued Strong Growth in Second Quarter Aug 2, 2005 Cephalon Reports Continued Strong Growth in Second Quarter Aug 2, 2005 AE2S adds Long to its Moorhead office Jul 23, 2005 King George III's Madness Worsened by Arsenic Jul 21, 2005 Cephalon, Inc. Completes Acquisition of TRISENOX From Cell ... Jul 19, 2005 Cephalon, Inc. Completes Acquisition of TRISENOX(R) From Cell ... Jul 19, 2005 NEWS RELEASE Jul 19, 2005 Final chapter for Yellowknife's Giant Mine Jul 18, 2005 | ||
| Dosage Forms | TABLET | ||
| Drug_Category | Antineoplastic Agents; Homeopathic Agents; ATC:L01XX27 | ||
| Absorption | Not Available | ||
| Interactions |
Drug Interactions for Arsenic Trioxide: No formal assessments of pharmacokinetic drug-drug interactions between TRISENOXô and other agents have been conducted. Caution is advised when TRISENOXô is coadministered with other medications that can prolong the QT interval (e.g. certain antiarrhythmics or thioridazine) or lead to electrolyte abnormalities (such as diuretics or amphotericin B). | ||
| Toxicity | Not Available | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | Not Available | ||
| Chemical Formula | As2O3 | ||
| Molecular Weight | 197.841 g/mol | ||
| Smiles String | O=[As]O[As]=O | ||
| Melting Point | Not Available | ||
| Water Solubility | Not Available | ||
| State | Solid | ||
| LogP/Hphobicity | Not Available | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Not Available | ||
| Half Life | Not Available | ||
| Protein Binding [%] | 75% bound-tissue | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Arsenic_Trioxide.html http://www.rxlist.com/cgi/generic2/arsenic.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00171 | ||
| CAS Registry Number | 1327-53-3 | ||
| KEGG Compound ID | Not Available | ||
| PubChem ID | SID:14549 | ||
| PharmGKB ID | PA448486 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 718777 |
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