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Arcitumomab
drug data and news
Arcitumomab drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
| Generic name |
Arcitumomab
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| Brand Names/Synonyms |
CEA-Scan; CEA-Scan (Immunomedics Inc) |
| Indication |
For imaging colorectal tumors |
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Description |
Reduced Fab fragment of the murine IgG1 monoclonal antibody IMMU-4 (also called NP-4) with specificity for carcinoembryonic antigen (CEA) covalently labeled with Technitium 99. The molecule has a molecular weight of ~54,000 Daltons. |
| Pharmacology |
Binds to the carcinoembryonic antigen, which is a cell surface protein generally overexpressed in colon (and other) cancers. The radioactive Tc99, which is covalently attached to the antibody, allows radiodiagnostic detection of CEA expressing cells and tumors |
| Mechanism Of Action |
Binds selectively to cell-surface carcinoembryonic antigen (CEA) expressed on colorectal tumors. |
Arcitumomab News
(When available) |
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| Dosage Forms |
Not Available |
| Drug_Category |
Diagnostic Agents; Imaging Agents |
| Absorption |
Not Available |
| Interactions |
Not Available |
| Toxicity |
Not Available |
| Organisms Affected |
Not Available |
| Chemical IUPAC Name |
AntiCEA antibody |
| Chemical Formula |
C6398H9900N1714O1995S54 >1clo: Anti-CEA antigen light chain 1 >1clo:Anti-CEA heavy chain 2 >1clo: Anti-CEA antigen light chain 2 |
| Molecular Weight |
144482.5 |
| Smiles String |
Not Available |
| Melting Point |
61 oC (FAB fragment), 71 oC (whole mAb) - Vermeer, A.W.P. & Norde, W., Biophys. J. 78:394-404 (2000). |
| Water Solubility |
Not Available |
| State |
Transparent, slightly viscous, aqueous liquid |
| LogP/Hphobicity |
-0.423 |
| Isoelectric Point |
8.26 |
| Biotransformation |
Most likely removed by opsonization via the reticuloendothelial system, or by human antimurine antibody production |
| Half Life |
~1 hours |
| Protein Binding [%] |
Not Available |
| RxList Link |
Not Available>RXlist |
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| Drug Reference |
Not Available |
| Drug Type |
Approved Drug |
| Accession No |
BIOD00107 |
| CAS Registry Number |
154361-48-5 |
| KEGG Compound ID |
Not Available |
| PubChem ID |
Not Available |
| PharmGKB ID |
PA10334 |
| SwissProt ID |
Not Available |
| GenBank ID |
Not Available |
| Drug ID Number [DIN] |
Not Available
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