Apomorphine drug data and news

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Kyowa Hakko Kogyo to Introduce Self-Injectable Drug for Treating ...  Feb 22, 2006
...announced on February 22 that it has concluded a licensing agreement with UK company Britannia Pharmaceuticals for a self-injectable formulation of apomorphine ... - Japan Corporate News (press release),

Race on to develop women’s yes-yes-yes pill  Feb 11, 2006
Several other companies, including Vectura, a British firm, are preparing drugs based on the chemical apomorphine, which works by mimicking dopamine, the brain ... - Times Online,

Interest aroused in a female love drug  Feb 12, 2006
Several other companies are preparing drugs based on the chemical apomorphine, which mimics dopamine, the brain's "signalling" chemical. ... - Australian,

5HT₃ Antagonists

Based on reports of profound hypotension and loss of consciousness when apomorphine was administered with ondansetron, the concomitant use of apomorphine with drugs of the 5HT³ antagonist class (including, for example, ondansetron, granisetron, dolasetron, palonosetron, and alosetron) is contraindicated .

Antihypertensive Medications and Vasodilators

The following adverse events were experienced more commonly in patients receiving concomitant antihypertensive medications or vasodilators (n = 94) compared to patients not receiving these concomitant drugs (n = 456): hypotension 10% vs 4%, myocardial infarction 3% vs 1%, serious pneumonia 5% vs 3%, serious falls 9% vs 3%, and bone and joint injuries 6% vs 2%. The mechanism underlying many of these events is unknown, but may represent increased hypotension . Dopamine Antagonists

Since apomorphine is a dopamine agonist, it is possible that dopamine antagonists, such as the neuroleptics (phenoth-iazines, butyrophenones, thioxanthenes) or metoclopramide, may diminish the effectiveness of APOKYN. Patients with major psychotic disorders, treated with neuroleptics, should be treated with dopamine agonists only if the potential benefits outweigh the risks.

Drugs Prolonging the QT/QTc Interval

Caution should be exercised when prescribing apomorphine concomitantly with drugs that prolong the QT/QTc interval.

Drug/Laboratory Test Interactions

There are no known interactions between APOKYN and laboratory tests.