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Antithymocyte globulin
drug data and news
Antithymocyte globulin drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Antithymocyte globulin | ||
| Brand Names/Synonyms | Thymoglobulin; Thymoglobulin (SangStat Medical; Genzyme) | ||
| Indication | For prevention of renal transplant rejection | ||
| Sponsored links | Description | Rabbit anti-thymocyte globulin. Thymoglobulin is a polyclonal antibody that suppresses certain types of immune cells responsible for acute organ rejection in transplant patients. Thymoglobulin is a mixture of antibodies intended to bind to various cell surface antigens. The most common mode of action of Thymoglobulin is via selective depletion of T-cells. | |
| Pharmacology | This immunosuppressive product, obtained by immunization of rabbits with human thymocytes, contains cytotoxic antibodies directed against antigens expressed on human T-lymphocytes. This reduces the host immune response against tissue transplants or organ allografts. | ||
| Mechanism Of Action | Binds to multiple, T-cell specific antigens leading to T-lymphocyte cell death via complement mediated cytotoxicity or apoptosis. | ||
| Antithymocyte globulin News (When available) |
Bone marow disease at core Feb 16, 2006 | ||
| Dosage Forms | POWDER FOR SOLUTION | ||
| Drug_Category | Immunomodulatory Agents; unclassified therapeutic agents (92:00.00) | ||
| Absorption | Not Available | ||
| Interactions | Not Available | ||
| Toxicity | Not Available | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | Rabbit anti-thymocyte globulin | ||
| Chemical Formula | Not Available | ||
| Molecular Weight | Not Available | ||
| Smiles String | Not Available | ||
| Melting Point | 61 oC (FAB fragment), 71 oC (whole mAb) - Vermeer, A.W.P. & Norde, W., Biophys. J. 78:394-404 (2000). | ||
| Water Solubility | Not Available | ||
| State | Transparent, slightly viscous, aqueous liquid | ||
| LogP/Hphobicity | Not Available | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Most likely removed by opsonization via the reticuloendothelial system when bound to T lymphocytes, or by human antimurine antibody production. | ||
| Half Life | 2-3 days | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | Not Available>RXlist | ||
| Sponsored links | |||
| Drug Reference | Not Available | ||
| Drug Type | Approved Drug | ||
| Accession No | BIOD00040 | ||
| CAS Registry Number | Not Available | ||
| KEGG Compound ID | Not Available | ||
| PubChem ID | Not Available | ||
| PharmGKB ID | PA10250 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2246805 |
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