| Generic name |
Anistreplase
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| Brand Names/Synonyms |
Tissue-type plasminogen activator precursor;tPA;t- PA;t-plasminogen activator;Alteplase;Reteplase; Eminase (Wulfing Pharma GmbH) |
| Indication |
For lysis of acute pulmonary emboli, intracoronary emboli and management of myocardial infarction |
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Description |
Human tissue plasminogen activator, purified, glycosylated, 527 residues purified from CHO cells. Eminase is a lyophilized (freeze-dried) formulation of anistreplase, the p-anisoyl derivative of the primary Lys-plasminogen-streptokinase activator complex (a complex of Lys-plasminogen and streptokinase). A p-anisoyl group is chemically conjugated to a complex of bacterial-derived streptokinase and human Plasma-derived Lys-plasminogen proteins. |
| Pharmacology |
Anistreplase cleaves the Arg/Val bond in plasminogen to form plasmin. Plasmin in turn degrades the fibrin matrix of the thrombus, thereby exerting its thrombolytic action. This helps eliminate blood clots or arterial blockages that cause myocardial infarction. |
| Mechanism Of Action |
Anistreplase cleaves the Arg/Val bond in plasminogen to form plasmin. This in turn leads to the degradation of blood clots. |
Anistreplase News
(When available) |
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| Dosage Forms |
POWDER FOR SOLUTION |
| Drug_Category |
Thrombolytic Agents |
| Absorption |
Not Available |
| Interactions |
Not Available |
| Toxicity |
Not Available |
| Organisms Affected |
Humans and other mammals |
| Chemical IUPAC Name |
Human tissue plasminogen activator |
| Chemical Formula |
C2569H3928N746O781S40 |
| Molecular Weight |
59042.3 |
| Smiles String |
Not Available |
| Melting Point |
60 oC (Novokhatny, V.V. et al., J. Biol. Chem. 266:12994-123002 (1991)) |
| Water Solubility |
Not Available |
| State |
Transparent, slightly viscous, aqueous liquid |
| LogP/Hphobicity |
-0.516 |
| Isoelectric Point |
7.61 |
| Biotransformation |
Not Available |
| Half Life |
Not Available |
| Protein Binding [%] |
Not Available |
| RxList Link |
Not Available>RXlist |
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| Drug Reference |
http://www.drugs.com/cons/Anistreplase.html |
| Drug Type |
Approved Drug |
| Accession No |
BIOD00102 |
| CAS Registry Number |
81669-57-0 |
| KEGG Compound ID |
Not Available |
| PubChem ID |
Not Available |
| PharmGKB ID |
PA448439 |
| SwissProt ID |
TPA_HUMAN (P00750) |
| GenBank ID |
L00153 |
| Drug ID Number [DIN] |
2229390
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