Anastrozole drug data and news

Anastrozole drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name Anastrozole
Brand Names/Synonyms Anastrole; Anastrozol; Anastrozole; Anastrozole [Usan:Ban:Inn]; Arimidex; CHEMBANK1630; ICI-D 1033; ZD 1033
Indication For treatment of advanced breast cancer.
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Description Not Available
Pharmacology Anastrozole is a potent and selective non-steroidal aromatase inhibitor indicated for the treatment of advanced breast cancer in post-menopausal women with disease progression following tamoxifen therapy. Many breast cancers have estrogen receptors and growth of these tumors can be stimulated by estrogens. In post-menopausal women, the principal source of circulating estrogen (primarily estradiol) is conversion of adrenally-generated androstenedione to estrone by aromatase in peripheral tissues, such as adipose tissue, with further conversion of estrone to estradiol. Many breast cancers also contain aromatase; the importance of tumor-generated estrogens is uncertain. Treatment of breast cancer has included efforts to decrease estrogen levels by ovariectomy premenopausally and by use of anti-estrogens and progestational agents both pre- and post-menopausally, and these interventions lead to decreased tumor mass or delayed progression of tumor growth in some women. Anastrozole is a potent and selective non-steroidal aromatase inhibitor. It significantly lowers serum estradiol concentrations and has no detectable effect on formation of adrenal corticosteroids or aldosterone.
Mechanism Of Action Anastrozole selectively inhibits aromatase. The principal source of circulating estrogen (primarily estradiol) is conversion of adrenally-generated androstenedione to estrone by aromatase in peripheral tissues. Therefore, aromatase inhibition leads to a decrease in circulatin estrogen, leading to a decreased tumor mass or delayed progression of tumor growth in some women.
Anastrozole News
(When available)

CA 50: By Helping Himself, Roach May Help Competition  Feb 22, 2006
Brennan Bilberry, communications director for Busby’s campaign, said the amendment highlights the differences between her campaign and Roach’s. “We have ... - CQPolitics.com,

Busby to respond to Bush address  Mar 3, 2006
...only the second congressional candidate invited to make the Democratic rebuttal in more than a year, according to her communications director, Brennan Bilberry ... - San Diego Union Tribune,

The eyes have it  Mar 3, 2006
Bilberry extracts contain substances known as anthocyanosides which act as powerful antioxidants in lens and macular tissue and can also strengthen connective ... - Saga Health News,

Busby gets support from leading Democrat  Feb 18, 2006
Busby spokesman Brennan Bilberry said Friday that it's no coincidence that Busby's campaign is drawing the attention of Democrats at the national level. ... - North County Times,

Youth Lines  Feb 26, 2006
...fourth place team. Television News Anchor Team: Katie Bilberry, Corey Huston-Liter and Ben Gorman, first place team. Individual Web ... - Bryan College Station Eagle,

Special Features Block New  Feb 19, 2006
...confirmation that Francine is running against a group of career politicians and millionaires trying to buy this election," Busby spokesman Brennan Bilberry said ... - TPMCafe,

ASK THE DOCTOR: Vitamins won't cure macular degeneration, but ...  Feb 20, 2006
...your routine. The AREDs study did not evaluate the usefulness of some other antioxidants such as bilberry and lutein. Clinical trials ... - Asheville Citizen-Times,

Beauty of striking a balance with nature  Feb 25, 2006
...at Lake Vyrnwy. They rely on the flying insects attracted to new growth and on the young heather and bilberry shoots. Mike Walker ... - ic Wales,

Mudslinging begins in 50th District race  Feb 5, 2006
...research. "We certainly want to make sure that we have a complete profile, so we know who our opponents are," said Brennan Bilberry. ... - North County Times,

HIV/AIDs awareness needs rekindled sense of urgency  Feb 7, 2006
The center will present "Defining Moments," a skit to be performed between 4:30 and 6:30 pm today at Bilberry Park, 1902 Alabama St., in Shreveport. ... - Shreveport Times,

Expensive Race  Feb 13, 2006
Francine Busby, a Democrat from Cardiff, has received about $520,000 in contributions, according to Brennan Bilberry, Busby's campaign communication director. ... - XETV FOX6 San Diego,

Local Briefs: Memorial, funeral for Ron Capone scheduled  Feb 4, 2006
Queensborough Neighborhood Association will hold a free homebuyers seminar today at Bilberry Park Recreation Center, 1905 Alabama St. in Shreveport. ... - Shreveport Times,

Cactus Botanics introduces Black Soybean Hull Extract  Feb 14, 2006
Bilberry Extract is an effective anti-oxidant, largely because of its active ingredients- Anthocyanins. Of these anthocyanins, cyanidin ... - NPIcenter (press release),

Market America harnesses the selling power of stars  Feb 11, 2006
...a $67.95 custom-made skin-care cocktail called Ashanti's OPC-3 Beauty Blend, which includes ingredients such as extracts of red wine, bilberry, citrus and ... - Miami Herald,

HIV/AIDs awareness needs rekindled sense of urgency  Feb 7, 2006
The center will present "Defining Moments," a skit to be performed between 4:30 and 6:30 pm today at Bilberry Park, 1902 Alabama St., in Shreveport. ... - Shreveport Times,

New plan for Miami golf course  Jan 23, 2006
An internal memo from Laura Bilberry, director of public facilities for the city of Miami, to city manager Joe Arriola indicated that the market conditions in ... - Miami Herald,

Mudslinging begins in 50th District race  Feb 5, 2006
...research. "We certainly want to make sure that we have a complete profile, so we know who our opponents are," said Brennan Bilberry. ... - North County Times,

Local Briefs: Memorial, funeral for Ron Capone scheduled  Feb 4, 2006
Queensborough Neighborhood Association will hold a free homebuyers seminar today at Bilberry Park Recreation Center, 1905 Alabama St. in Shreveport. ... - Shreveport Times,

Steps to combat tired eyes  Jan 28, 2006
3. Supplementation with eye herbs such as bilberry, eyebright, lycium (kei chi in Chinese) and spinach may help ease tired eyes. ... - Malaysia Star,

Strategists say securing religious vote key in 50th District race  Jan 29, 2006
Busby's communication director, Brennan Bilberry, said last week that while Busby had visited several religious congregations in the last month, she didn't ... - North County Times,

NS’s official berry could hold key to better vision after dark  Jan 11, 2006
Could the secret of the British success really have been in the bilberry jam they ate? Folklore, backed up by some European research, says that might be true. ... - Halifax Herald (subscription),

Give up smoking with some natural help  Jan 10, 2006
Natural Green foods such as wheatgrass, barleygrass, alfalfa and bilberry and the minerals calcium, magnesium and zinc help with this process. ... - Open PR (press release),

Style calendar  Jan 22, 2006
Pure-grade natural ingredients in the line include collagen-boosting bilberry; skin-brightening mulberry, skin-firming Japanese seaweed, oil-absorbing pumpkin ... - Cincinnati Enquirer,

No matter how tough his day, he extended his hand to others  Jan 24, 2006
Hawthorne Road. Mr. Duford's funeral will be held Thursday at 2 pm at Divine Infant Roman Catholic Church, 6658 Bilberry Dr., Orleans. - Ottawa Citizen,

Municipal Court  Jan 8, 2006
Fine/fees were $95. On Nov. 30, John Bilberry pleaded guilty and was found guilty of speeding 16-20 mph over the limit. Fine/fees were $145. On Nov. ... - Los Alamos Monitor,

Dosage Forms tablets containing 1mg anastrozole
Drug_Category Antineoplastic Agents; ATC:L02BG03
Absorption Absorbed into the systemic cirulation, and food does not affect the extent of absorption.
Interactions -->Interactions for Anastrozole:

Anastrozole inhibited in vitro metabolic reactions catalyzed by cytochromes P450 1A2, 2C8/9, and 3A4 but only at relatively high concentrations. Anastrozole did not inhibit P450 2A6 or the polymorphic P450 2D6 in human liver microsomes. Anastrozole did not alter the pharmacokinetics of antipyrine. Although there have been no formal interaction studies other than with antipyrine, based on these in vivo and in vitro studies, it is unlikely that co-administration of a 1 mg dose of ARIMIDEX with other drugs will result in clinically significant drug inhibition of cytochrome P450-mediated metabolism of the other drugs.

An interaction study with warfarin showed no clinically significant effect of anastrozole on warfarin pharmacokinetics or anticoagulant activity.

At a median follow-up of 33 months, the combination of ARIMIDEX and tamoxifen did not demonstrate any efficacy benefit when compared with tamoxifen in all patients as well as in the hormone receptor-positive subpopulation. This treatment arm was discontinued from the trial. Based on clinical and pharmacokinetic results from the ATAC trial, tamoxifen should not be administered with anastrozole (see CLINICAL PHARMACOLOGY ñ Drug Interactions and CLINICAL PHARMACOLOGY - Clinical Studies - Adjuvant Treatment of Breast Cancer in Postmenopausal Women subsections). Co-administration of anastrozole and tamoxifen resulted in a reduction of anastrozole plasma levels by 27% compared with those achieved with anastrozole alone.

Estrogen-containing therapies should not be used with ARIMIDEX as they may diminish its pharmacologic action.

Drug/Laboratory Test Interactions

No clinically significant changes in the results of clinical laboratory tests have been observed.

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Toxicity In rats, lethality is greater than 100mg/kg.
Organisms Affected Humans and other mammals
Chemical IUPAC Name 2-[3-(1-cyano-1-methyl-ethyl)-5-(1H-1,2,4-triazol-1-ylmethyl)phenyl]-2-methyl-propanenitrile
Chemical Formula C17H19N5
Molecular Weight 293.366 g/mol
Smiles String CC(C)(C#N)C1=CC(=CC(=C1)CN2C=NC=N2)C(C)(C)C#N
Melting Point 130.14 °C
Water Solubility 0.5mg/ml
State off-white powder
LogP/Hphobicity 4.501
Isoelectric Point Not Available
Biotransformation Hepatic. Metabolized mainly by N -dealkylation, hydroxylation, and glucuronidation to inactive metabolites. Primary metabolite is an inactive triazole.
Half Life 50 hours
Protein Binding [%] 40%
RxList Link RXlist
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Drug Reference http://www.drugs.com/cons/Anastrozole.html
http://www.rxlist.com/cgi/generic2/anastr.htm
Drug Type Approved Drug
Accession No APRD00016
CAS Registry Number 120511-73-1
KEGG Compound ID C08159
PubChem ID SID:63297
PharmGKB ID PA448432
SwissProt ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] 2224135

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