|
![]() |
|
|
Anakinra
drug data and news
Anakinra drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
|
| Generic name | Anakinra | ||
| Brand Names/Synonyms | Interleukin-1 receptor antagonist protein precursor;IL-1ra;IRAP;IL1 inhibitor;IL-1RN;ICIL-1RA; Kineret (Amgen Inc) | ||
| Indication | For treatment of adult rheumatoid arthritis | ||
| Sponsored links | Description | Recombinant human interleukin-1 receptor antagonist. Has an extra Met at N-terminus, expressed in E. coli. 153 residues, MW=17.3 kD | |
| Pharmacology | Used to treat rheumatoid arthritis, Kineret blocks the biologic activity of IL-1 by competitively inhibiting IL-1 binding to the interleukin-1 type I receptor (IL-1RI), which is expressed in a wide variety of tissues and organs.1 IL-1 production is induced in response to inflammatory stimuli and mediates various physiologic responses including inflammatory and immunological responses. Patients with rheumatoid arthritis have elevated levels of IL-1. The levels of the naturally occurring IL-1Ra in synovium and synovial fluid from rheumatoid arthritis (RA) patients are not sufficient to compete with the elevated amount of locally produced IL-1. Increasing the levels of IL-1Ra by artificial means reduces the negative effects (cartilage degradation, bone resorption) of IL-1. | ||
| Mechanism Of Action | Kineret binds to the Interleukin-1 type I receptor (IL-1RI), thereby inhibiting the action of elevated levels IL-1 leading to cartilage degradation and bone resorption. | ||
| Anakinra News (When available) |
1 From the Department of Medicine, Division of Infectious Diseases ... Feb 14, 2006 NPS Pharmaceuticals Reports Fourth Quarter and Year-End Operating ... Feb 16, 2006 Rheumatic Diseases Remain a Significant Cause of Chronic Illness ... Feb 22, 2006 Better Fix For Rheumatoid Arthritis Feb 16, 2006 American Journal of Clinical Nutrition, Vol. 83, No. 2, 475S-483S ... Feb 17, 2006 NPS Pharmaceuticals Reports Fourth Quarter and Year-End Operating ... Feb 16, 2006 Better Fix for Rheumatoid Arthritis Feb 1, 2006 HUMIRA(R) (Adalimumab) Shows Promise in Treating Patients With ... Nov 13, 2005 HUMIRA (Adalimumab) Receives FDA Approval for Treatment of ... Oct 4, 2005 Psoriatic arthritis, FDA approves Humira for reducing signs and ... Oct 5, 2005 Era of molecular biology has been boon to rheumatologists Oct 3, 2005 Xoma names new vice president Jul 28, 2005 XOMA Appoints Alan M. Solinger, MD as Vice President of Clinical ... Jul 28, 2005 Treating RA: Recent Evidence from the European League Against ... Jul 25, 2005 Xoma names new vice president Jul 28, 2005 XOMA Appoints Alan M. Solinger, MD as Vice President of Clinical ... Jul 28, 2005 Treating RA: Recent Evidence from the European League Against ... Jul 25, 2005 Anakinra in the treatment of children with juvenile arthritis May 27, 2005 Success in Treatment of Children with Juvenile Arthritis May 28, 2005 New Phase III Data Shows Nearly Four Out Of Five Crohn's Patients ... May 16, 2005 Crohn’s disease, efficacy of the treatment with Adalimumab May 17, 2005 Blocking IL-1 in systemic inflammation May 2, 2005 NPS Pharmaceuticals and Ventiv Health Announce the Launch of a ... Mar 3, 2005 NPS Pharmaceuticals and Ventiv Health Announce the Launch of a ... Mar 3, 2005 Psoriasis patients receiving HUMIRA® (adalimumab) achieved ... Feb 22, 2005 | ||
| Dosage Forms | SOLUTION | ||
| Drug_Category | Immunomodulatory Agents; Antirheumatic Agents; unclassified therapeutic agents (92:00.00) | ||
| Absorption | Not Available | ||
| Interactions | Not Available | ||
| Toxicity | Not Available | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | Human interleukin-1 receptor antagonist protein | ||
| Chemical Formula | C759H1186N208O232S10 | ||
| Molecular Weight | 17257.6 | ||
| Smiles String | Not Available | ||
| Melting Point | Not Available | ||
| Water Solubility | Not Available | ||
| State | Transparent, slightly viscous, aqueous liquid | ||
| LogP/Hphobicity | -0.412 | ||
| Isoelectric Point | 5.46 | ||
| Biotransformation | Not Available | ||
| Half Life | 4-6 hrs | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Anakinra.html http://www.rxlist.com/cgi/generic/anakinra.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | BIOD00060 | ||
| CAS Registry Number | Not Available | ||
| KEGG Compound ID | Not Available | ||
| PubChem ID | Not Available | ||
| PharmGKB ID | PA10799 | ||
| SwissProt ID | IL1RA_HUMAN (P18510) | ||
| GenBank ID | M55646 | ||
| Drug ID Number [DIN] | 2245913 |
|
Home | About | Cancers | Treatment | Medications Copyright onconews.org 2005. All Rights Reserved. |