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Ampicillin
drug data and news
Ampicillin drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Ampicillin | ||
| Brand Names/Synonyms | AB-PC; AIC; AMPICILLIN; AY 6108; AY-6108; Ab-Pc Sol; Acillin; Adobacillin; Alpen; Amblosin; Amcill; Amfipen; Amfipen V; Aminobenzylpenicillin; Amipenix S; Ampen; Ampi; Ampi-Bol; Ampi-Co; Ampi-Tab; Ampichel; Ampicil; Ampicilina [Inn-Spanish]; Ampicillin; Ampicillin A; Ampicillin Acid; Ampicillin Anhydrate; Ampicillin Anhydrous; Ampicillin Base; Ampicillin Sodium; Ampicillin Trihydrate; Ampicillin [Usan:Ban:Inn:Jan]; Ampicillina [Dcit]; Ampicilline; Ampicilline [Inn-French]; Ampicillinum [Inn-Latin]; Ampicin; Ampifarm; Ampikel; Ampimed; Ampipenin; Ampipenin, Nt3; Ampiscel; Ampisyn; Ampivax; Ampivet; Amplacilina; Amplin; Amplipenyl; Amplisom; Amplital; Ampy-Penyl; Anhydrous Ampicillin; Austrapen; BA 7305; BRL; BRL 1341; BRL-1341; Bayer 5427; Binotal; Bonapicillin; Britacil; Campicillin; Cimex; Copharcilin; D-Ampicillin; D-Cillin; Delcillin; Deripen; Divercillin; Doktacillin; Duphacillin; Geocillin; Grampenil; Guicitrina; Guicitrine; HI 63; HSDB 3009; Lifeampil; Morepen; NCI-C56086; NSC 528986; NSC-528986; Norobrittin; Novo-Ampicillin; Nuvapen; Olin Kid; Omnipen; Omnipen-N; Orbicilina; P 50; P-50; Pen A; Pen Ampil; Pen a Oral; Penbristol; Penbritin; Penbritin Paediatric; Penbritin Syrup; Penbritin-S; Penbrock; Penicline; Penimic; Pensyn; Pentrex; Pentrexl; Pentrexyl; Pfizerpen A; Pfizerpen-A; Polycillin; Polycillin-N; Ponecil; Princillin; Principen; Principen '125'; Principen '250'; Principen '500'; Qidamp; Racenacillin; Ro-Ampen; Rosampline; Roscillin; SQ 17382; Semicillin; Semicillin R; Servicillin; Sk-Ampicillin; Spectrobid; Sumipanto; Supen; Synpenin; Texcillin; Tokiocillin; Tolomol; Totacillin; Totacillin-N; Totalciclina; Totapen; Trifacilina; Ultrabion; Ultrabron; Vampen; Viccillin; Viccillin S; WY-5103; Wypicil | ||
| Indication | For treatment of infection (Respiratory, GI, UTI and meningitis) due to E. coli, P. mirabilis, enterococci, Shigella, S. typhosa and other Salmonella, nonpenicillinase-producing N. gononhoeae, H. influenzae, staphylococci, streptococci including streptoc | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Ampicillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Ampicillin has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Ampicillin results from the inhibition of cell wall synthesis and is mediated through Ampicillin binding to penicillin binding proteins (PBPs). Ampicillin is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases. | ||
| Mechanism Of Action | By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Ampicillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Ampicillin interferes with an autolysin inhibitor. | ||
| Ampicillin News (When available) |
Comval Board to probe 1000% alleged medicine overprice 06 Mar 2006 Adamantane Resistance in Influenza A Feb 21, 2006 Rethinking UTI Prophylaxis Mar 1, 2006 South Florida-based study on antibiotics could change treatment ... Feb 3, 2006 Fuel Prices: Where Are the Palliative Measures? Feb 6, 2006 Pediatrix Data Mining Identifies Favorable Antibiotic Combination ... Jan 27, 2006 South Florida-based study on antibiotics could change treatment ... Feb 3, 2006 Fuel Prices: Where Are the Palliative Measures? Feb 6, 2006 Tackling vaginal discharge irritation\ Jan 30, 2006 Malaria, AIDS, Avian Flu, and MRSA-will we survive? Jan 19, 2006 Punjab: Pollution hits groundwater Jan 31, 2006 Anti-dumping probe initiated on pen-G imports from China Jan 21, 2006 American Pharmaceutical Partners Receives FDA Approval for ... Nov 30, 2005 (PRN) - American Pharmaceutical Partners Receives FDA Approval for ... Nov 30, 2005 American Pharmaceutical Partners Receives FDA Approval for ... Nov 30, 2005 Rare Fatal Toxic Shock Reported Following Medical Abortions Dec 1, 2005 APP gets FDA OK for generic Unasyn Nov 30, 2005 Killer to serve at least 15 years Dec 2, 2005 Orchid eyes $60 mn from new facility Dec 2, 2005 Will I conceive again after Injectaplan? Dec 2, 2005 Practical Equine Medications Dec 3, 2005 Antibiotics segment ailing due to high input costs Oct 17, 2005 Prescribing medicine in Ramzan Oct 20, 2005 Sterling buys Torrent unit for $12.3 million Oct 17, 2005 Sterling Biotech buys Torrent unit for Rs 55 cr Oct 13, 2005 Carrying the modern toxic load Sep 30, 2005 Two Arrested After Agents Raid Spanish Grocery Store Oct 11, 2005 Study: Failure of Initial Antibiotic Therapy Leads to Higher ... Oct 7, 2005 Grocers jailed in medication case Oct 13, 2005 Jamaica receives $1.2 million in medical supplies from ADRA Sep 29, 2005 Two Arrested After Agents Raid Spanish Grocery Store 11 Oct 2005 Study: Failure of Initial Antibiotic Therapy Leads to Higher ... Oct 7, 2005 Jamaica Receives $1.2 Million in Medical Supplies from ADRA Sep 28, 2005 Carrying the modern toxic load Sep 30, 2005 The Spread of Antibiotic-Resistant Bacteria in Gulf Coast Sep 22, 2005 Doctor faces lawsuit over patient death Sep 25, 2005 Health ministry gets J$75-m in supplies Sep 21, 2005 Nabi Biopharmaceuticals Receives Favorable Opinion From the ... Sep 22, 2005 The world is fast becoming fat and rotund. Is the industrially ... Sep 13, 2005 Why we banned imported drugs-Obasanjo Sep 7, 2005 Inflation falls to 3.08 pc Sep 2, 2005 Science of Sport: Eleutherococcus Senticosus - Can adaptogens help ... Sep 3, 2005 GeoPharma Acquires Controlling Interest in Antibiotic ... Aug 17, 2005 Hunting good bacteria Aug 27, 2005 Drug interactions with the pill Aug 31, 2005 Lyme Disease Aug 30, 2005 Highlights From MMWR: Measles Outbreaks Underscore Need for ... Aug 29, 2005 Fla. company takes Consolidated Pharmaceutical's drugs Aug 16, 2005 Weak medicine Aug 16, 2005 The Housing Bubble Revisited Aug 17, 2005 SICK PSUS COME TO RESCUE OF MUMBAI Aug 18, 2005 It's Bye Bye to Ignorance Aug 23, 2005 | ||
| Dosage Forms | POWDER FOR SOLUTION | ||
| Drug_Category | Anti-bacterial Agents; Penicillins; ATC:J01CA01; ATC:J01CA02; ATC:J01CA06; ATC:J01CA14; ATC:J01CA15; ATC:S01AA19 | ||
| Absorption | Not Available | ||
| Interactions |
-->Interactions for Ampicillin: When administered concurrently, the following drugs may interact with ampicillin. Allopurinol: Increased possibility of skin rash, particularly in hyperuricemic patients may occur. Bacteriostatic Antibiotics: Chloramphenicol, erythromycins, sulfonamides, or tetracyclines may interfere with the bactericidal effect of penicillins. This has been demonstrated in view, however, the clinical significance of this interaction is not well documented. Oral Contraceptives: May be less effective and increased breakthrough bleeding may occur. Probenecid: May decrease renal tubular secretion of ampicillin resulting in increased blood levels and/or ampicillin toxicity. Drug/Laboratory Test Interaction After treatment with ampicillin, a false-positive reaction for glucose in the urine may occur with copper sulfate tests (Benedict's solution, Fehling's solution, or Clinitest tablets) but not with enzyme based tests such as Clinistix and Glucose Enzymatic Test Strip USP. | ||
| Toxicity | Not Available | ||
| Organisms Affected | Enteric bacteria and other eubacteria | ||
| Chemical IUPAC Name | 7-(2-amino-2-phenyl-acetyl)amino-3,3-dimethyl-6-oxo-2-thia-5-azabicyclo[3.2.0]heptane-4-carboxylicacid | ||
| Chemical Formula | C16H19N3O4S | ||
| Molecular Weight | 349.406 g/mol | ||
| Smiles String | CC1(C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=CC=C3)N)C(=O)O)C | ||
| Melting Point | 208 °C | ||
| Water Solubility | 1.01E+004 mg/L | ||
| State | Solid | ||
| LogP/Hphobicity | 1.35 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Not Available | ||
| Half Life | Not Available | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Ampicillin.html http://www.rxlist.com/cgi/generic/ampicillin.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00320 | ||
| CAS Registry Number | 69-53-4 | ||
| KEGG Compound ID | C06574 | ||
| PubChem ID | SID:149171 | ||
| PharmGKB ID | PA448419 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2227029 |
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