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Amphetamine
drug data and news
Amphetamine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Amphetamine | ||
| Brand Names/Synonyms | Actedron; Adipan; Allodene; Amphetamine; Amphetamine Sulfate; Anorexide; Anorexine; Benzebar; Benzedrine; Benzolone; Desoxyn; Dexampex; Dexedrine; Dextroamphetamine Sulfate; Dextrostat; Elastonon; Fenamin; Fenylo-izopropylaminyl; Ferndex; Finam; Isoamycin; Isoamyne; Isomyn; Mecodrin; Methampex; Methamphetamine HCL; Norephedrane; Norephedrine, deoxy-; Novydrine; Oktedrin; Ortedrine; Paredrine; Percomon; Phenamine; Phenedrine; Phenylisopropylamine; Profamina; Propisamine; Psychedrine; Raphetamine; Rhinalator; Simpatedrin; Simpatina; Sympamin; Sympamine; Sympatedrine; Weckamine; amphetamine base; dl-Amphetamine; dl-Benzedrine; m-Methoxyamphetamine; alpha-Methylbenzeneethaneamine; beta-Aminopropylbenzene; (+/-)-Desoxynorephedrine; (+/-)-beta-Phenylisopropylamine; (+/-)-Benzedrine; (+/-)-Desoxynorephedrine; 1-Methyl-2-phenylethylamine; 1-Phenyl-2-aminopropane; 3-Methoxy-a-methylbenzeneethanamine; 3-Methoxyamphetamine; 3-Methoxyphenylisopropylamine; Amphetamine (Narcotics); DL-alpha-Methylphenethylamine; [1-(3-Methoxyphenyl)-2-propyl]amine; dl-1-Phenyl-2-aminopropane; m-Methoxy-a-methylphenethylamine; racemic-Desoxynor-ephedrine | ||
| Indication | For treatment of Attention Deficit Disorder with Hyperactivity (ADDH) and narcolepsy in children. | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Amphetamine and dextroamphetamine, non-catechloamine sypathomimetic agents, are used in combination to treat attention-deficit hyperactivity disorder (ADHD) or narcolepsy. Adderall consists of equivalent amounts of amphetamine aspartate, amphetamine sulfate, dextroamphetamine saccharate, and dextroamphetamine sulfate. | ||
| Mechanism Of Action | Amphetamine and dextroamphetamine stimulate the release of norepinephrine from central adrenergic receptors. At higher dosages, they cause release of dopamine from the mesocorticolimbic system and the nigrostriatal dopamine systems. Amphetamine may also act as a direct agonist on central 5-HT receptors and may inhibit monoamine oxidase (MAO). In the periphery, amphetamines are believed to cause the release of noradrenaline by acting on the adrenergic nerve terminals and alpha- and beta-receptors. Modulation of serotonergic pathways may contribute to the calming affect. | ||
| Amphetamine News (When available) |
Baseball to sell approved supplements; Fehr sees no need for more ... 06 Mar 2006 What Ecstasy does to you 06 Mar 2006 Keep ‘ice’ ingredients behind store counters 06 Mar 2006 New drug rules, end of CBA on minds of Phillies, Fehr 06 Mar 2006 The increasing challenge of fighting meth's grip 06 Mar 2006 Pringle: Psych Drugs Used To Manufacture Insanity 06 Mar 2006 Drug bust caps long local probe 06 Mar 2006 Baseball players face a change of pace with new policy on ... Mar 5, 2006 EDITORIAL: Meth Treatment: Can Nation Get a Grip on Drug Woes? Mar 4, 2006 Amphetamine seizures increase in Myanma Mar 1, 2006 Arkansas ranks 10th for treating meth users Mar 4, 2006 Admissions to Treatment for Methamphetamine Abuse Rise Sharply Mar 2, 2006 2 arrested for theft, meth lab Mar 2, 2006 i tried adderall Mar 5, 2006 Admissions to Treatment for Methamphetamine Abuse Rise Sharply Mar 2, 2006 Monoaminergic Treatment of Schizophrenia Feb 27, 2006 Stimulant Medications: How to Minimize Their Reinforcing Effects? Mar 2, 2006 Experts point finger at leader Mar 5, 2006 More users get meth treatment Mar 3, 2006 Meth boom crowding drug treatment clinics Mar 3, 2006 Meth treatment programs face growing demand Mar 3, 2006 NEW NOVEL TRANSFORMS WWE SUPERSTARS INTO SUPERSPIES Mar 5, 2006 'I thought I was dying . . .' Mar 5, 2006 Game should provide stimulant for players Feb 27, 2006 State reports sharp rise in meth abuse Mar 2, 2006 In a First, Big Leagues Just Say No to Greenies Feb 27, 2006 Downer criticised over Bali Nine appeals Feb 28, 2006 Government drug war aid 'essential' Mar 1, 2006 Who are they trying to kid? Mar 4, 2006 Meth grip on nation Mar 2, 2006 US Sees Sharp Rise in People Seeking Treatment for Meth Abuse Mar 3, 2006 Drug trade will be one of Portia's biggest challenges Mar 4, 2006 STAR'S SISTER 'RAPED BY CABBIE AFTER GIVING IOU' Feb 27, 2006 Adderall Online: Black Market Profits In Plain Sight Mar 3, 2006 COMPLETE BREAKDOWN OF WWE WELLNESS PROGRAM Feb 27, 2006 From Bench to Bedside: The Future of Neuroimaging Tools in ... Feb 27, 2006 9-month-old tests positive for methamphetamine, cocaine Mar 3, 2006 Operation Chamform Mar 2, 2006 Official fired after positive drug test Mar 3, 2006 Drug task force raids net 2 arrests Mar 2, 2006 Drugs seized in house raids Mar 2, 2006 ADHD Individual Drug Risk Studies To Be Considered By Drug Safety ... Feb 8, 2006 COURT - Warning on illicit drugs Feb 15, 2006 Shire plc: Strong 2005 Performance Supports Positive Outlook Feb 23, 2006 Two charged over drug lab Feb 9, 2006 Deadly rampage of loner 'who dreamt of being a serial killer' Feb 28, 2006 | ||
| Dosage Forms | tablets combining the neutral sulfate salts of dextroamphetamine and amphetamine, with the dextroisomer of amphetamine saccharate and 6, I-amphetamine aspartate. | ||
| Drug_Category | Adrenergic Agents; Dopamine Agents; Dopamine Uptake Inhibitors; Adrenergic Uptake Inhibitors; Central Nervous System Stimulants; Amphetamines; Sympathomimetics; ATC:N06BA01 | ||
| Absorption | It forms easily absorbed molecules that are highly lipid soluble | ||
| Interactions | Acidifying agents - Gastrointestinal acidifying agents (guanethidine,reserpine, glutamic acid HCl,ascorbic acid, fruit juices, etc.) lower absorption of amphetamines. Urinary acidifying agents -(ammonium chloride, sodium acid phosphate, etc.) Increase the concentration of the ionized species of the amphetamine. Primary excretion - Both Groups of agents lower blood levels and efficacy of amphetamines. Adrenergic blockers - Adrenergic blockers are inhibited by amphetamines. Alkalinizing agents -Gastrointestinal alkalinizing agents (sodium bicarbonate, etc.)increase absorption of amphetamines. Urinary alkalinizing agents (acetazolamide, some thiazides) increase the concentration of the non-ionized species of the amphetamine molecule, thereby decreasing urinary excretion. Both groups of agents increase blood levels and therefore potentate the actions of amphetamines. Antidepressants, tricyclic - Amphetamines may enhance the activity of tricyclic or sympathomimetic agents; d-amphetamine with desipramine or protriptyline and possibly other tricyclics cause striking and sustained increases in the concentration of d-amphetamine in the brain; cardiovascular effects can be potentiated. MAO inhibitors - MAO antidepressants, as well as a metabolite of furazolidone, slow amphetamine metabolism. This slowing potentiates amphetamines, increasing their effect on the release of norepinephrine and other monoamines from adrenergic nerve endings, this can cause headaches and other signs of hypertensive crisis. A variety of neurological toxic effects and malignant hyperpyrexia can occur, sometimes with fatal results. Antihistamines - Amphetamines may counteract the sedative effect of antihistamines. Antihypertensives - Amphetamines may antagonize the hypotensive effects of antihypertensives. Chlorpromazine - Chlorpromazine blocks dopamine and norepinephrine receptors, thus inhibiting the central stimulant effects of amphetamines, and can be used to treat amphetamine poisoning. Ethosuximide - Amphetamines may delay intestinal absorption of ethosuximide. Haloperidol - Haloperidol blocks dopamine receptors, thus inhibiting the central stimulant effects of amphetamines. Lithium carbonate - The anorectic and stimulatory effects of amphetamines may be inhibited by lithium carbonate. Meperidine - Amphetamines pone the analgesic effect of meperidine. Methenamine therapy - Urinary excretion of amphetamines is increased, and efficacy is reduced, by acidifying agents used in methenamine therapy. Norepinephrine - Amphetamines enhance the adrenergic effect of norepinephrine. Phenobarbital - Amphetamines may delay intestinal absorption of phenobarbital; co-administration of phenobarbital may produce a synergistic anticonvulsant action. Phenytoin - Amphetamines may delay intestinal absorption of phenytoin; co-administration of phenytoin may produce a synergistic anticonvulsant action. Propoxyphene - In cases of propoxyphene overdose, amphetamine CNS stimulation is potentiated and fatal convulsions can occur. Veratrum alkaloids - Amphetamines inhibit the hypotensive effect of veratrum alkaloids. Drug/Laboratory Test Interactions Amphetamines can cause a significant elevation in plasma corticosteroid levels. This increase is greatest in the evening. Amphetamines may interfere with urinary steroid determinations. | ||
| Toxicity | LD50=180 mg/kg(s.c in rat). The most common presenting symptoms seen are agitation, hallucinations, suicidal behaviour, and chest pain. | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 1-phenylpropan-2-amine | ||
| Chemical Formula | C9H13N | ||
| Molecular Weight | 135.206 g/mol | ||
| Smiles String | CC(CC1=CC=CC=C1)N | ||
| Melting Point | Volatizes slowly at room temperature | ||
| Water Solubility | Slightly | ||
| State | A white, odourless, crystalline powder | ||
| LogP/Hphobicity | 1.799 | ||
| Isoelectric Point | 10.1 | ||
| Biotransformation | Hepatic | ||
| Half Life | 10 hours | ||
| Protein Binding [%] | 15-40% | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/add1008.shtml http://www.drugs.com/cons/Amphetamine.html http://www.rxlist.com/cgi/generic3/adderallxr.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00480 | ||
| CAS Registry Number | 300-62-9 | ||
| KEGG Compound ID | C07514 | ||
| PubChem ID | SID:148619 | ||
| PharmGKB ID | Not Available | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2248813 |
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