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Amlodipine
drug data and news
Amlodipine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Amlodipine | ||
| Brand Names/Synonyms | AMLODIPINE BESYLATE, 99%; Amlocard; Amlodipine; Amlodipine Benzenesulfonate; Amlodipine Besilate; Amlodipine Besylate; Amlodipine Free Base; Amlodipino [Spanish]; Amlodipinum [Latin]; Amlodis; Amvaz; CHEMBANK1767; Coroval; Lipinox; Lotrel; Norvasc | ||
| Indication | For the treatment of hypertension, chronic stable angina and confirmed or suspected vasospastic angina | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Amlodipine, a calcium-channel blocker, is used alone or with benazepril, an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina. Amlodipine is similar to the peripheral vasodilator nifedipine and other members of the dihydropyridine class. | ||
| Mechanism Of Action | Amlodipine is a calcium channel blocking agent. It inhibits the influx of extracellular calcium across the myocardial and vascular smooth muscle cell membranes. The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload. Another possible mechanism is that Amlodipine inhibits vascular smooth muscle carbonic anhydrase I activity with consecutive pH increase which may be involved in intracelluar calcium influx through calcium channels | ||
| Amlodipine News (When available) |
Pan Fish completes placing to finance Marine Harvest buy ... 07 Mar 2006 Suspension not commensurate with crime: Bodies 07 Mar 2006 Ruling bloc eyes extending suspension term for problem lawmakers+ 07 Mar 2006 We should have say on Ken’s suspension 07 Mar 2006 Vice mayor mum on mayor's suspension Mar 5, 2006 Broken Suspension Ends Murray's Night Early Mar 5, 2006 Inquiry needed before any cell service sales suspension Mar 5, 2006 Iran proposes ‘selective suspension’ of enrichment Mar 3, 2006 (BW) Alcon Withdraws European Application for RETAANE(R) ... Mar 3, 2006 23 years of suspension for taking Rs 50 as bribe Mar 3, 2006 Santhanam suspension from AIFB stayed Mar 4, 2006 Suspension muddle leaves black eye Mar 3, 2006 Flyers' Brashear handed one game suspension Mar 3, 2006 Officer gets suspension over alleged sex remarks Mar 3, 2006 Britain: Behind the suspension of London Mayor Ken Livingstone Mar 3, 2006 Brashear given game suspension Mar 4, 2006 Lowe Confirms Lace Suspension Mar 3, 2006 Union: Suspension will stifle class discussion Mar 3, 2006 Flyer facing suspension Mar 3, 2006 Lower Loup NRD approves well suspension Mar 4, 2006 Trading suspension puts brakes on a wild ride Mar 4, 2006 Companies listed on AIM face suspension Mar 3, 2006 Strict Teacher Faces Suspension Mar 3, 2006 Court agrees to freeze Livingstone suspension as mayor until ... Mar 1, 2006 Livingstone confirms appeal against suspension Feb 27, 2006 London Mayor Blames Panel and Jewish Group for His Suspension Feb 28, 2006 Mayor's suspension frozen Feb 28, 2006 Livingstone launches appeal over Nazi jibe suspension Feb 27, 2006 Nazi slur: court blocks mayor's suspension Feb 28, 2006 London Mayor appeals against his suspension Feb 27, 2006 Mayor Ken to appeal against suspension Feb 27, 2006 London Mayor Asks High Court to Overturn Suspension, Ruling Feb 27, 2006 Livingstone to fight suspension Feb 27, 2006 London Mayor challenges suspension Feb 27, 2006 Ken Livingstone's suspension frozen by judge Feb 28, 2006 Nazi row mayor suspension blocked Feb 28, 2006 Judge freezes Livingstone suspension Feb 28, 2006 Court Weighs London Mayor's Suspension Feb 28, 2006 City employee sues to reverse suspension Mar 2, 2006 Iran: No suspension of U-enrichment needed Mar 1, 2006 Livingstone to appeal against four-week suspension Feb 27, 2006 EU demands Iran reinstate suspension of uranium enrichment Feb 28, 2006 Blair 'backs Livingstone suspension challenge' Feb 27, 2006 London mayor to appeal suspension Feb 27, 2006 | ||
| Dosage Forms | white tablets equivalent to 2.5, 5 and 10 mg | ||
| Drug_Category | Vasodilator Agents; Antianginal; Antihypertensive Agents; Calcium Channel Blockers; ATC:C08CA01 | ||
| Absorption | Amlodipine is slowly and almost completely absorbed from the gastrointestinal tract. | ||
| Interactions |
-->Interactions for Amlodipine: In vitro data indicate that NORVASC has no effect on the human plasma protein binding of digoxin, phenytoin, warfarin, and indomethacin. Effect of other agents on NORVASC. CIMETIDINE: Co-administration of NORVASC with cimetidine did not alter the pharmacokinetics of NORVASC. GRAPEFRUIT JUICE: Co-administration of 240 mL of grapefruit juice with a single oral dose of amlodipine 10 mg in 20 healthy volunteers had no significant effect on the pharmacokinetics of amlodipine. MAALOX (antacid): Co-administration of the antacid Maalox with a single dose of NORVASC had no significant effect on the pharmacokinetics of NORVASC. SILDENAFIL: A single 100 mg dose of sildenafil (ViagraÒ) in subjects with essential hypertension had no effect on the pharmacokinetic parameters of NORVASC. When NORVASC and sildenafil were used in combination, each agent independently exerted its own blood pressure lowering effect. Effect of NORVASC on other agents. ATORVASTATIN: Co-administration of multiple 10 mg doses of NORVASC with 80 mg of atorvastatin resulted in no significant change in the steady state pharmacokinetic parameters of atorvastatin. DIGOXIN: Co-administration of NORVASC with digoxin did not change serum digoxin levels or digoxin renal clearance in normal volunteers. ETHANOL (alcohol): Single and multiple 10 mg doses of NORVASC had no significant effect on the pharmacokinetics of ethanol. WARFARIN: Co-administration of NORVASC with warfarin did not change the warfarin prothrombin response time. In clinical trials, NORVASC has been safely administered with thiazide diuretics, beta-blockers, angiotensin-converting enzyme inhibitors, long-acting nitrates, sublingual nitroglycerin, digoxin, warfarin, non-steroidal anti-inflammatory drugs, antibiotics, and oral hypoglycemic drugs. Drug/Laboratory Test Interactions: None known. | ||
| Toxicity | Gross overdosage could result in excessive peripheral vasodilatation and possibly reflex tachycardia. Marked and probably prolonged systemic hypotension up to an including shock with fatal outcome have been reported. | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | methylethyl2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate | ||
| Chemical Formula | C20H25ClN2O5 | ||
| Molecular Weight | 408.876 g/mol | ||
| Smiles String | CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN | ||
| Melting Point | 178-179°C | ||
| Water Solubility | 75.3mg/L | ||
| State | White crystalline powder | ||
| LogP/Hphobicity | 2.347 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | hepatic metabolism | ||
| Half Life | 30-50 hours | ||
| Protein Binding [%] | 97.50% | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Amlodipine.html http://www.rxlist.com/cgi/generic/amlod2.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00520 | ||
| CAS Registry Number | 88150-42-9 | ||
| KEGG Compound ID | C06825 | ||
| PubChem ID | SID:193166 | ||
| PharmGKB ID | PA448388 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 878936 |
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