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Amikacin
drug data and news
Amikacin drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Amikacin | ||
| Brand Names/Synonyms | ANTIBIOTIC BB-K8; Amicacin; Amiglyde-V; Amikacin; Amikacin Base; Amikacin Dihydrate; Amikacin Sulfate; Amikacin [Usan:Ban:Inn]; Amikacina [Inn-Spanish]; Amikacine [Inn-French]; Amikacinum [Inn-Latin]; Amikavet; Amikin; BB-K8; Briclin; Novamin | ||
| Indication | For short-term treatment of serious infections due to susceptible strains of Gram-negative bacteria, including Pseudomonas species, Escherichia coli, species of indole-positive and indole-negative Proteus, Providencia species, Klebsiella-Enterobacter-Serratia species, and Acinetobacter (Mima-Herellea) species. | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Amikacin is an aminoglycoside antibiotic. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit, causing misreading of t-RNA, leaving the bacterium unable to synthesize proteins vital to its growth. Aminoglycosides are useful primarily in infections involving aerobic, Gram-negative bacteria, such as Pseudomonas, Acinetobacter, and Enterobacter. In addition, some mycobacteria, including the bacteria that cause tuberculosis, are susceptible to aminoglycosides. Infections caused by Gram-positive bacteria can also be treated with aminoglycosides, but other types of antibiotics are more potent and less damaging to the host. In the past the aminoglycosides have been used in conjunction with penicillin-related antibiotics in streptococcal infections for their synergistic effects, particularly in endocarditis. Aminoglycosides are mostly ineffective against anaerobic bacteria, fungi and viruses. | ||
| Mechanism Of Action | Aminoglycosides like Amikacin "irreversibly" bind to specific 30S-subunit proteins and 16S rRNA. Amikacin inhibits protein synthesis by binding to the 30S ribosomal subunit to prevent the formation of an initiation complex with messenger RNA. Specifically Amikacin binds to four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes. | ||
| Amikacin News (When available) |
Nektar Announces Financial Results for the Year and Fourth Quarter ... Feb 28, 2006 Nektar Announces Financial Results for the Year and Fourth Quarter ... Feb 28, 2006 | ||
| Dosage Forms | IV Infusion; IM Injection | ||
| Drug_Category | Anti-bacterial Agents; Aminoglycosides; ATC:D06AX12; ATC:J01GB06; ATC:S01AA21 | ||
| Absorption | Rapidly absorbed after intramuscular administration | ||
| Interactions |
Interactions for Amikacin: No information provided. | ||
| Toxicity | Not Available | ||
| Organisms Affected | Enteric bacteria and other eubacteria | ||
| Chemical IUPAC Name | 4-amino-N-[5-amino-2-[4-amino-3,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-4-[6-(aminomethyl)-3,4,5-trihydroxy-tetrahydropyran-2-yl]oxy-3-hydroxy-cyclohexyl]-2-hydroxy-butanamide | ||
| Chemical Formula | C22H43N5O13 | ||
| Molecular Weight | 585.603 g/mol | ||
| Smiles String | C1C(C(C(C(C1NC(=O)C(CCN)O)OC2C(C(C(C(O2)CO)O)N)O)O)OC3C(C(C(C(O3)CN)O)O)O)N | ||
| Melting Point | 203-204 °C | ||
| Water Solubility | 1.85E+005 mg/L | ||
| State | Solid | ||
| LogP/Hphobicity | -9.048 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Not Available | ||
| Half Life | 2-3 hours | ||
| Protein Binding [%] | 0-11% | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Amikacin.html http://www.rxlist.com/cgi/generic3/amikacin.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00550 | ||
| CAS Registry Number | 37517-28-5 | ||
| KEGG Compound ID | C06820 | ||
| PubChem ID | SID:9038 | ||
| PharmGKB ID | PA448366 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2242971 |
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