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Alprenolol
drug data and news
Alprenolol drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
| Generic name |
Alprenolol
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| Brand Names/Synonyms |
A131; Alfeprol; Alfeprol [Russian]; Alpheprol; Alprenolol; Alprenololum [Inn-Latin]; Apllobal; Aptine; Aptol Duriles; CHEMBANK690; Gubernal; H 56/28; Regletin; Yobir |
| Indication |
For the treatment of hypertension, angina, and arrhythmia |
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Description |
Not Available |
| Pharmacology |
Alprenolol is a non-selective beta-blocker used in the treatment of hypertension, edema, ventricular tachycardias, and atrial fibrillation. Alprenolol impairs AV node conduction and decreases sinus rate and may also increase plasma triglycerides and decrease HDL-cholesterol levels. Alprenolol is nonpolar and hydrophobic, with low to moderate lipid solubility. Alprenolol has little to no intrinsic sympathomimetic activity and, unlike some other beta-adrenergic blocking agents, alprenolol has little direct myocardial depressant activity and does not have an anesthetic-like membrane-stabilizing action. |
| Mechanism Of Action |
Alprenolol non-selectively blocks beta-1 adrenergic receptors mainly in the heart, inhibiting the effects of epinephrine and norepinephrine resulting in a decrease in heart rate and blood pressure. By binding beta-2 receptors in the juxtaglomerular apparatus, alprenolol inhibits the production of renin, thereby inhibiting angiotensin II and aldosterone production and therefore inhibits the vasoconstriction and water retention due to angiotensin II and aldosterone, respectively. |
Alprenolol News
(When available) |
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| Dosage Forms |
TABLET |
| Drug_Category |
Sympatholytics; Antihypertensive Agents; Antiarrhythmic Agents; ATC:C07AA01 |
| Absorption |
Not Available |
| Interactions |
Not Available |
| Toxicity |
Oral, rat LD50: 597.0 mg/kg |
| Organisms Affected |
Humans and other mammals |
| Chemical IUPAC Name |
1-(1-methylethylamino)-3-(2-prop-2-enylphenoxy)-propan-2-ol |
| Chemical Formula |
C15H23NO2 |
| Molecular Weight |
249.349 g/mol |
| Smiles String |
CC(C)NCC(COC1=CC=CC=C1CC=C)O |
| Melting Point |
107-109 °C |
| Water Solubility |
547 mg/L |
| State |
Solid |
| LogP/Hphobicity |
3.144 |
| Isoelectric Point |
Not Available |
| Biotransformation |
Hepatic. One of the active metabolites, 4-OH-alprenolol, is an active beta-blocker. |
| Half Life |
2-3 hours |
| Protein Binding [%] |
80-90% |
| RxList Link |
Not Available>RXlist |
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| Drug Reference |
Not Available |
| Drug Type |
Approved Drug |
| Accession No |
APRD00736 |
| CAS Registry Number |
13655-52-2 |
| KEGG Compound ID |
Not Available |
| PubChem ID |
SID:168916 |
| PharmGKB ID |
Not Available |
| SwissProt ID |
Not Available |
| GenBank ID |
Not Available |
| Drug ID Number [DIN] |
Not Available
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