| Generic name |
Alpha-1-proteinase inhibitor
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| Brand Names/Synonyms |
Alpha-1-antitrypsin precursor;Alpha-1 protease inhibitor;Alpha-1- antiproteinase; Aralast (Baxter); Prolastin (Talecris Biotherapeutics ¨C formerly Bayer) |
| Indication |
For treatment of panacinar emphysema |
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Description |
Human alpha-1 proteinase inhibitor or alpha-1-antitrypsin, prepared from human plasma via Cohn alcohol fractionation followed by PEG and zinc chloride fractionation. |
| Pharmacology |
Prevents excessive accumulation of active neutrophil elastase and consequent proteolysis of elastin tissues in alveolar lung structures. This prevents the development of emphysema. |
| Mechanism Of Action |
Alpha-1 proteinase inhibitor is a serine protease inhibitor (Serpin). It primarily inhibits the action of the serine protease called elastase (also plasmin and thrombin). The reactive center loop (RCL) of alpha-1 proteinase inhibitor extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable. |
Alpha-1-proteinase inhibitor News
(When available) |
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| Dosage Forms |
POWDER FOR SOLUTION |
| Drug_Category |
Enzyme replacement; enzymes (44:00.00) |
| Absorption |
Not Available |
| Interactions |
Not Available |
| Toxicity |
Not Available |
| Organisms Affected |
Humans and other mammals |
| Chemical IUPAC Name |
Alpha-1-proteinase inhibitor |
| Chemical Formula |
C2001H3130N514O601S10 |
| Molecular Weight |
44324.5 |
| Smiles String |
Not Available |
| Melting Point |
59 oC at pH 7.8 (Tew D.J., Bottomley, S.P. J. Mol. Biol. 313:1161-1169 (2001)). |
| Water Solubility |
Not Available |
| State |
Transparent, slightly viscous, aqueous liquid |
| LogP/Hphobicity |
-0.302 |
| Isoelectric Point |
5.37 |
| Biotransformation |
Not Available |
| Half Life |
Not Available |
| Protein Binding [%] |
Not Available |
| RxList Link |
RXlist |
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| Drug Reference |
http://www.rxlist.com/cgi/generic3/zemaira.htm |
| Drug Type |
Approved Drug |
| Accession No |
BIOD00002 |
| CAS Registry Number |
9041-92-3 |
| KEGG Compound ID |
Not Available |
| PubChem ID |
Not Available |
| PharmGKB ID |
PA448329 |
| SwissProt ID |
A1AT_HUMAN (P01009) |
| GenBank ID |
K01396 |
| Drug ID Number [DIN] |
2204606
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