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Alitretinoin
drug data and news
Alitretinoin drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Alitretinoin | ||
| Brand Names/Synonyms | Alitretinoin; Alitretinoin [Usan]; Avita; Beta-Retinoic Acid; Panretin; Panretin Gel; Panretyn; Panrexin; Renova; Retin-A; Retin-a Micro; Retinoate; Retinoic Acid; Trans-Retinoic Acid; Tretin M; Tretinoin; Vesanoid; Vitamin a Acid | ||
| Indication | For topical treatment of cutaneous lesions in patients with AIDS- related Kaposi sarcomaia. | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Alitretinoin (9-cis-retinoic acid) is a naturally-occurring endogenous retinoid indicated for topical treatment of cutaneous lesions in patients with AIDS- related Kaposi's sarcoma. Alitretinoin inhibits the growth of Kaposi's sarcoma (KS) cells in vitro. | ||
| Mechanism Of Action | Alitretinoin binds to and activates all known intracellular retinoid receptor subtypes (RARa, RARb, RARg, RXRa, RXRb and RXRg). Once activated these receptors function as transcription factors that regulate the expression of genes that control the process of cellular differentiation and proliferation in both normal and neoplastic cells. | ||
| Alitretinoin News (When available) |
(PZ) Basilea Pharmaceutica Ltd. Reports 2005 Financial Results Feb 27, 2006 Basilea announces positive phase III results for ceftobiprole, its ... Mar 2, 2006 Basilea Pharmaceutica Ltd. Reports its Interim Results Aug 23, 2005 Ordinary General Meeting of Shareholders of Basilea Pharmaceutica ... Apr 12, 2005 Basilea's First-in-Class Antibiotic BAL5788 (Ceftobiprole) Moves ... Apr 7, 2005 Basilea Announces 2004 Financial Results Reflecting Successful ... Mar 9, 2005 Basilea Investigates Novel Antibiotic Class with Potential to ... Mar 7, 2005 | ||
| Dosage Forms | Not Available | ||
| Drug_Category | Antineoplastic Agents; ATC:L01XX22 | ||
| Absorption | Not Available | ||
| Interactions |
Interactions for Alitretinoin: Patients who are applying Panretin® gel should not concurrently use products that contain DEET (N, N-diethyl-m-toluamide), a common component of insect repellent products. Animal toxicology studies showed increased DEET toxicity when DEET was included as proof of the formulation. Although there was no clinical evidence in the vehicle-controlled studies of drug interactions with systemic antiretroviral agents, including protease inhibitors, macrolide antibiotics, and azole antifungals, the effect of Panretin® gel on the steady-state concentrations of these drugs is not known. No drug interaction data are available on concomitant administration of Panretin® gel and systemic anti-KS agents. | ||
| Toxicity | Not Available | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)-nona-2,4,6,8-tetraenoicacid | ||
| Chemical Formula | C20H28O2 | ||
| Molecular Weight | 300.435 g/mol | ||
| Smiles String | CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C | ||
| Melting Point | 189-190 °C | ||
| Water Solubility | 0.6 mg/L | ||
| State | Solid | ||
| LogP/Hphobicity | 5.067 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Not Available | ||
| Half Life | Not Available | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Alitretinoin.html http://www.rxlist.com/cgi/generic2/alitre.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00017 | ||
| CAS Registry Number | 3/8/5300 | ||
| KEGG Compound ID | Not Available | ||
| PubChem ID | SID:164122 | ||
| PharmGKB ID | PA448089 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | Not Available |
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