Alitretinoin drug data and news

Alitretinoin drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name Alitretinoin
Brand Names/Synonyms Alitretinoin; Alitretinoin [Usan]; Avita; Beta-Retinoic Acid; Panretin; Panretin Gel; Panretyn; Panrexin; Renova; Retin-A; Retin-a Micro; Retinoate; Retinoic Acid; Trans-Retinoic Acid; Tretin M; Tretinoin; Vesanoid; Vitamin a Acid
Indication For topical treatment of cutaneous lesions in patients with AIDS- related Kaposi sarcomaia.
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Description Not Available
Pharmacology Alitretinoin (9-cis-retinoic acid) is a naturally-occurring endogenous retinoid indicated for topical treatment of cutaneous lesions in patients with AIDS- related Kaposi's sarcoma. Alitretinoin inhibits the growth of Kaposi's sarcoma (KS) cells in vitro.
Mechanism Of Action Alitretinoin binds to and activates all known intracellular retinoid receptor subtypes (RARa, RARb, RARg, RXRa, RXRb and RXRg). Once activated these receptors function as transcription factors that regulate the expression of genes that control the process of cellular differentiation and proliferation in both normal and neoplastic cells.
Alitretinoin News
(When available)

(PZ) Basilea Pharmaceutica Ltd. Reports 2005 Financial Results  Feb 27, 2006
...announced positive phase II trial results on our novel broad-spectrum antifungal drug BAL8557 and our international phase III alitretinoin registration trial ... - Houston Chronicle,

Basilea announces positive phase III results for ceftobiprole, its ...  Mar 2, 2006
About Alitretinoin (BAL4079) Alitretinoin is a novel vitamin A analog that is developed for patients with chronic hand eczema that is refractory to ... - PharmaLive.com (press release),

Basilea Pharmaceutica Ltd. Reports its Interim Results  Aug 23, 2005
The increase in R&D spending resulted primarily from progress in late stage development of Alitretinoin (BAL4079) for the treatment of chronic refractory hand ... - PrimeZone (press release),

Ordinary General Meeting of Shareholders of Basilea Pharmaceutica ...  Apr 12, 2005
BAL5788) into phase III in complicated skin and skin structure infections and hospital acquired pneumonia; the entry of alitretinoin (BAL4079) for severe ... - ArriveNet

Basilea's First-in-Class Antibiotic BAL5788 (Ceftobiprole) Moves ...  Apr 7, 2005
...including the entry of ceftobiprole (BAL5788) into phase III in complicated skin and skin structure infections; the entry of alitretinoin (BAL4079) for severe ... - ArriveNet,

Basilea Announces 2004 Financial Results Reflecting Successful ...  Mar 9, 2005
Basilea commenced its alitretinoin phase III program in severe chronic hand dermatitis refractory to topical treatment -- October 2004. ... - PrimeZone (press release),

Basilea Investigates Novel Antibiotic Class with Potential to ...  Mar 7, 2005
...months, Basilea also announced three additional major company milestones including entry of ceftobiprole into phase III, entry of alitretinoin (BAL4079) in ... - PrimeZone (press release),

Dosage Forms Not Available
Drug_Category Antineoplastic Agents; ATC:L01XX22
Absorption Not Available
Interactions Interactions for Alitretinoin:

Patients who are applying Panretin® gel should not concurrently use products that contain DEET (N, N-diethyl-m-toluamide), a common component of insect repellent products. Animal toxicology studies showed increased DEET toxicity when DEET was included as proof of the formulation. Although there was no clinical evidence in the vehicle-controlled studies of drug interactions with systemic antiretroviral agents, including protease inhibitors, macrolide antibiotics, and azole antifungals, the effect of Panretin® gel on the steady-state concentrations of these drugs is not known. No drug interaction data are available on concomitant administration of Panretin® gel and systemic anti-KS agents.

Toxicity Not Available
Organisms Affected Humans and other mammals
Chemical IUPAC Name 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)-nona-2,4,6,8-tetraenoicacid
Chemical Formula C20H28O2
Molecular Weight 300.435 g/mol
Smiles String CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C
Melting Point 189-190 °C
Water Solubility 0.6 mg/L
State Solid
LogP/Hphobicity 5.067
Isoelectric Point Not Available
Biotransformation Not Available
Half Life Not Available
Protein Binding [%] Not Available
RxList Link RXlist
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Drug Reference http://www.drugs.com/cons/Alitretinoin.html
http://www.rxlist.com/cgi/generic2/alitre.htm
Drug Type Approved Drug
Accession No APRD00017
CAS Registry Number 3/8/5300
KEGG Compound ID Not Available
PubChem ID SID:164122
PharmGKB ID PA448089
SwissProt ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] Not Available

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