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Adinazolam
drug data and news
Adinazolam drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Adinazolam | ||
| Brand Names/Synonyms | ADINAZOLAM; Adinazolam [Usan:Ban:Inn]; Adinazolam [Usan]; Adinazolamum [Inn-Latin]; U 41123 | ||
| Indication | For treatment of panic disorder | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Adinazolam is a benzodiazepine derivative used to treat anxiety, status epilepticus, and for sedation induction and anterograde amnesia. Adinazolam binds with high affinity to the GABA benzodiazepine receptor complex. Considerable evidence suggest that the central pharmacologic/therapeutic actions of alprazolam are mediated via interaction with this receptor complex. | ||
| Mechanism Of Action | Adinazolam binds to peripheral-type benzodiazepine receptors which interact allosterically with GABA receptors. This potentiates the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking the cortical and limbic arousal that occurs following stimulation of the reticular pathways. | ||
| Adinazolam News (When available) |
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| Dosage Forms | Not Available | ||
| Drug_Category | Antidepressants; ATC:N05BA07 | ||
| Absorption | Not Available | ||
| Interactions |
Interactions for Adinazolam: Co-administration with antifungal agents such as ketoconazole or itraconazole is not recommended. Nafazodone, fluvoxamine, cimetidine (consider Xanax dose reduction). Fluoxetine, OCs, sertraline, diltiazem, macrolide antibiotics (exercise caution). | ||
| Toxicity | Signs of overdose may include muscle weakness, ataxia, dysarthria and particularly in children paradoxical excitement. In more severe cases diminished reflexes, confusion, and coma may ensue. | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | Not Available | ||
| Chemical Formula | C19H18ClN5 | ||
| Molecular Weight | 351.833 g/mol | ||
| Smiles String | CN(C)CC1=NN=C2N1C3=C(C=C(C=C3)Cl)C(=NC2)C4=CC=CC=C4 | ||
| Melting Point | Not Available | ||
| Water Solubility | Not Available | ||
| State | Solid | ||
| LogP/Hphobicity | 4.05 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Hepatic. | ||
| Half Life | Not Available | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | Not Available>RXlist | ||
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| Drug Reference | Not Available | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00724 | ||
| CAS Registry Number | 37115-32-5 | ||
| KEGG Compound ID | Not Available | ||
| PubChem ID | SID:178987 | ||
| PharmGKB ID | Not Available | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | Not Available |
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