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Adenosine
drug data and news
Adenosine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Adenosine | ||
| Brand Names/Synonyms | 2'-Deoxyadenosine; Adenine Deoxy Nucleoside; Adenine Deoxyribonucleoside; Adenine Deoxyribose; Adenine Nucleoside; Adenine Riboside; Adenocard; Adenocor; Adenoscan; Adenosin; Adenosine; Adenosine 99%; Adenosine for Biochemistry; Adenosine, Free Base; Adensoine; Adenyldeoxyriboside; Boniton; CCRIS 1782; Da; Deoxyadenosine; Desoxyadenosine; Myocol; Nucleocardyl; Sandesin; Usaf Cb-10 | ||
| Indication | For the conversion to sinus rhythm of paroxysmal supraventricular tachycardia (PSVT), including that associated with accessory bypass tracts (Wolff-Parkinson-White Syndrome) | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Adenosine is an endogenous nucleoside occurring in all cells of the body and is not chemically related to other antiarrhythmic drugs. Adenosine is indicated for the conversion to sinus rhythm of paroxysmal supraventricular tachycardia (PSVT), including that associated with accessory bypass tracts (Wolff-Parkinson-White Syndrome). Adenosine is antagonized competitively by methylxanthines such as caffeine and theophylline, and potentiated by blockers of nucleoside transport such as dipyridamole. Adenosine is not blocked by atropine. | ||
| Mechanism Of Action | Adenosine slows conduction time through the A-V node, can interrupt the reentry pathways through the A-V node, and can restore normal sinus rhythm in patients with paroxysmal supraventricular tachycardia (PSVT), including PSVT associated with Wolff-Parkinson-White Syndrome. | ||
| Adenosine News (When available) |
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| Dosage Forms | LIQUID | ||
| Drug_Category | Vasodilator Agents; Antiarrhythmic Agents; Analgesics; Cardiac drugs; ATC:C01EB10 | ||
| Absorption | Not Available | ||
| Interactions |
Interactions for Adenosine: Intravenous Adenocard (adenosine) has been effectively administered in the presence of other cardioactive drugs, such as quinidine, beta-adrenergic blocking agents, calcium channel blocking agents, and angiotensin converting enzyme inhibitors, without any change in the adverse reaction profile. Digoxin and verapamil use may be rarely associated with ventricular fibrillation when combined with Adenocard. Because of the potential for additive or synergistic depressant effects on the SA and AV nodes, however, Adenocard should be used with caution in the presence of these agents. The use of Adenocard in patients receiving digitalis may be rarely associated with ventricular fibrillation. The effects of adenosine are antagonized by methylxanthines such as caffeine and theophylline. In the presence of these methylxanthines, larger doses of adenosine may be required or adenosine may not be effective. Adenosine effects are potentiated by dipyridamole. Thus, smaller doses of adenosine may be effective in the presence of dipyridamole. Carbamazepine has been reported to increase the degree of heart block produced by other agents. As the primary effect of adenosine is to decrease conduction through the A-V node, higher degrees of heart block may be produced in the presence of carbamazepine. | ||
| Toxicity | Not Available | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol | ||
| Chemical Formula | C10H13N5O4 | ||
| Molecular Weight | 267.242 g/mol | ||
| Smiles String | C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)CO)O)O | ||
| Melting Point | 235.5 °C | ||
| Water Solubility | 8230 mg/L | ||
| State | Solid | ||
| LogP/Hphobicity | -2.115 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Not Available | ||
| Half Life | <10 secs | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference | http://www.rxlist.com/cgi/generic3/adenos.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00132 | ||
| CAS Registry Number | 58-61-7 | ||
| KEGG Compound ID | C00212 | ||
| PubChem ID | SID:327750 | ||
| PharmGKB ID | PA448049 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2243435 |
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