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Acamprosate
drug data and news
Acamprosate drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Acamprosate | ||
| Brand Names/Synonyms | Acamprosate; Acamprosate 6473; Acamprosate 6473 [Inn]; Acamprosato [Inn-Spanish]; Acamprosatum [Inn-Latin]; Campral; N-Acetylhomotaurine | ||
| Indication | For the maintenance of abstinence from alcohol in patients with alcohol dependence who are abstinent at treatment initiation | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Pharmacodynamic studies have shown that acamprosate calcium reduces alcohol intake in alcohol-dependent animals in a dose-dependent manner and that this effect appears to be specific to alcohol and the mechanisms of alcohol dependence. Acamprosate calcium has negligible observable central nervous system (CNS) activity in animals outside of its effects on alcohol dependence, exhibiting no anticonvulsant, antidepressant, or anxiolytic activity. | ||
| Mechanism Of Action | The mechanism of action of acamprosate in maintenance of alcohol abstinence is not completely understood. Chronic alcohol exposure is hypothesized to alter the normal balance between neuronal excitation and inhibition. in vitro and in vivo studies in animals have provided evidence to suggest acamprosate may interact with glutamate and GABA neurotransmitter systems centrally, and has led to the hypothesis that acamprosate restores this balance. | ||
| Acamprosate News (When available) |
Replidyne and Forest Laboratories Announce FDA Acceptance for ... Feb 23, 2006 Lactose intolerance can be counteracted with enzymes Feb 19, 2006 MILK SUGAR -- A PROBLEM FOR MANY Feb 13, 2006 What works in alcohol use disorders? Feb 9, 2006 Replidyne and Forest Laboratories Announce Faropenem Medoxomil ... Feb 13, 2006 | ||
| Dosage Forms | Not Available | ||
| Drug_Category | Alcohol Deterrents; ATC:N07BB03 | ||
| Absorption | Not Available | ||
| Interactions |
-->Interactions for Acamprosate: The concomitant intake of alcohol and CAMPRAL does not affect the pharmacokinetics of either alcohol or acamprosate. Pharmacokinetic studies indicate that administration of disulfiram or diazepam does not affect the pharmacokinetics of acamprosate. Co-administration of naltrexone with CAMPRAL produced a 25% increase in AUC and a 33% increase in the Cmax of acamprosate. No adjustment of dosage is recommended in such patients. The pharmacokinetics of naltrexone and its major metabolite 6-beta-naltrexol were unaffected following co-administration with CAMPRAL. Other concomitant therapies: In clinical trials, the safety profile in subjects treated with CAMPRAL concomitantly with anxiolytics, hypnotics and sedatives (including benzodiazepines), or non-opioid analgesics was similar to that of subjects taking placebo with these concomitant medications. Patients taking CAMPRAL concomitantly with antidepressants more commonly reported both weight gain and weight loss, compared with patients taking either medication alone. | ||
| Toxicity | Not Available | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 3-acetylaminopropane-1-sulfonicacid | ||
| Chemical Formula | C5H11NO4S | ||
| Molecular Weight | 181.211 g/mol | ||
| Smiles String | CC(=O)NCCCS(=O)(=O)O | ||
| Melting Point | Not Available | ||
| Water Solubility | Not Available | ||
| State | Solid | ||
| LogP/Hphobicity | -0.96 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Not Available | ||
| Half Life | 20 - 33 hours | ||
| Protein Binding [%] | Non detectable | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Acamprosate.html http://www.rxlist.com/cgi/generic3/campral.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00661 | ||
| CAS Registry Number | 77337-76-9 | ||
| KEGG Compound ID | Not Available | ||
| PubChem ID | SID:213365 | ||
| PharmGKB ID | PA10344 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | Not Available |
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