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Abarelix
drug data and news
Abarelix drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Abarelix | ||
| Brand Names/Synonyms | Plenaxis; Plenaxis (Praecis Pharmaceuticals) | ||
| Indication | For palliative treatment of advanced prostate cancer | ||
| Sponsored links | Description | Synthetic decapeptide antagonist to gonadotropin releasing hormone (GnRH) | |
| Pharmacology | Used in the palliative treatment of advanced prostate cancer. Abarelix is a luteinizing hormone agonist that results in suppression of testicular or follicular steroidogenesis. | ||
| Mechanism Of Action | Abarelix binds to the gonadotropin releasing hormone receptor and acts as a potent inhibitor of gonadotropin secretion. | ||
| Abarelix News (When available) |
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| Dosage Forms | Not Available | ||
| Drug_Category | Antineoplastic Agents; Anti-Testosterone Agents | ||
| Absorption | Not Available | ||
| Interactions | Not Available | ||
| Toxicity | Not Available | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | acetyl-D-ß-naphthylalanyl- D-4-chlorophenylalanyl-D-3-pyridylalanyl-L-seryl-L- N-methyl-tyrosyl-D-asparagyl-L-leucyl-L-N(e )-isopropyl-lysyl-L-prolyl-D-alanyl-amide | ||
| Chemical Formula | C72h95O14N14Cl | ||
| Molecular Weight | 1416.06 | ||
| Smiles String | Not Available | ||
| Melting Point | Not Available | ||
| Water Solubility | Not Available | ||
| State | Transparent, slightly viscous, aqueous liquid | ||
| LogP/Hphobicity | Not Available | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Not Available | ||
| Half Life | 13.2 +/- 3.2 days | ||
| Protein Binding [%] | 96-99% | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Abarelix.html http://www.rxlist.com/cgi/generic3/plenaxis.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | BIOD00051 | ||
| CAS Registry Number | 183552-38-7 | ||
| KEGG Compound ID | Not Available | ||
| PubChem ID | Not Available | ||
| PharmGKB ID | PA10002 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | Not Available |
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